PMID- 25377517
OWN - NLM
STAT- MEDLINE
DCOM- 20170817
LR  - 20170817
IS  - 1438-9592 (Electronic)
IS  - 0044-409X (Linking)
VI  - 141
IP  - 5
DP  - 2016 Oct
TI  - [The Influence of Laparoscopic Fundoplication on Reflux-Associated Cough].
PG  - 545-551
AB  - Introduction: The gastrooesophageal reflux disease (GERD) is a possible cause of 
      chronic cough. The laparoscopic fundoplication is well established in the 
      treatment of GERD. In a retrospective study, the effectivity of this operation on 
      the GERD associated cough was examined and possible preoperative predictive 
      factors concerning the post-surgical therapy effect were characterized. Patients 
      and Methods: 85 patients after laparoscopic fundoplication due to GERD treated 
      with proton pump inhibitors without (RS-H: n = 31) or with associated cough 
      (RS+H: n = 54) were evaluated in a three-month follow-up by data analysis 
      regarding an indication point score from typical symptoms as well as findings 
      (gastroscopy, histology, 24-hour oesophagus pH-metry). Results: For the leading 
      symptoms of heartburn and regurgitation a complete freedom from complaints was 
      reached with 98.8 % of all patients postal-surgically. In the group RS+H 70.4 % 
      of the patients were free of cough after 3 months, other 22.2 % with significant 
      improvement and 7.4 % with unchanged irritant cough. Higher values of the typical 
      reflux symptoms and a therapy resistance to proton pump inhibitors (PPI) were 
      clearly seen in the RS-H patients. The RS+H patients showed less reflux 
      complaints with lower PPI resistance, frequent allergies as well as significantly 
      more often an acid or bitter taste and hoarseness. After further subdivision of 
      the RS+H patients into the subgroups RS>H (mainly reflux, n = 31) and H>RS 
      (mainly cough), the lowest values for heartburn, regurgitation and PPI resistance 
      were found in subgroup H>RS. Diagnostics did not show any significiant 
      differences between the groups although a trend could be seen towards fewer 
      duodenogastric bile reflux, larger hiatus hernias and higher DeMeester scores in 
      RS+H and H>RS. Also smokers, non-allergic asthmatics and polyallergic sufferers 
      with cough profited from the intervention. Conclusion: Patients with 
      reflux-associated respiratory symptoms present an own entity with good PPI 
      therapy response to heartburn, but not to cough. They should be considered more 
      often for surgery. Since the cough symptoms in more than two-thirds of 
      appropriately selected patients disappear in a short time after surgery, 
      laparoscopic antireflux surgery should also be considered from pneumological 
      aspects. There are no individual predictors for the success of antireflux 
      surgery, only the sum of all relevant individual case history and clinical 
      criteria, as they are combined in the used score, can provide a reliable 
      indication for surgery.
CI  - Georg Thieme Verlag KG Stuttgart . New York.
FAU - Drews, G
AU  - Drews G
AD  - Klinik fur Allgemein- und Viszeralchirurgie, Krankenhaus Zerbst, Deutschland.
FAU - Rudolph, F
AU  - Rudolph F
AD  - Klinik fur Allgemein- und Viszeralchirurgie, Krankenhaus Zerbst, Deutschland.
FAU - Martinenko, O
AU  - Martinenko O
AD  - Klinik fur Allgemein- und Viszeralchirurgie, Krankenhaus Zerbst, Deutschland.
FAU - Kuhne, P
AU  - Kuhne P
AD  - Pneumologische Praxis, Zerbst, Deutschland.
FAU - Schreiber, J
AU  - Schreiber J
AD  - Klinik fur Pneumologie, Universitat Magdeburg, Deutschland.
LA  - ger
PT  - Journal Article
TT  - Einfluss der laparoskopischen Fundoplikation auf den mit gastroosophagealem 
      Reflux assoziierten Husten.
DEP - 20141106
PL  - Germany
TA  - Zentralbl Chir
JT  - Zentralblatt fur Chirurgie
JID - 0413645
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cough/etiology/*surgery
MH  - Female
MH  - Follow-Up Studies
MH  - Fundoplication/*methods
MH  - Gastroesophageal Reflux/diagnosis/*surgery
MH  - Humans
MH  - Laparoscopy/*methods
MH  - Male
MH  - Middle Aged
MH  - Postoperative Complications/etiology
EDAT- 2016/10/22 06:00
MHDA- 2017/08/18 06:00
CRDT- 2014/11/08 06:00
PHST- 2016/10/22 06:00 [pubmed]
PHST- 2017/08/18 06:00 [medline]
PHST- 2014/11/08 06:00 [entrez]
AID - 10.1055/s-0034-1382899 [doi]
PST - ppublish
SO  - Zentralbl Chir. 2016 Oct;141(5):545-551. doi: 10.1055/s-0034-1382899. Epub 2014 
      Nov 6.