PMID- 25378173
OWN - NLM
STAT- MEDLINE
DCOM- 20150120
LR  - 20200225
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Print)
IS  - 0270-6474 (Linking)
VI  - 34
IP  - 45
DP  - 2014 Nov 5
TI  - A model of synaptic vesicle-pool depletion and replenishment can account for the 
      interspike interval distributions and nonrenewal properties of spontaneous spike 
      trains of auditory-nerve fibers.
PG  - 15097-109
LID - 10.1523/JNEUROSCI.0903-14.2014 [doi]
AB  - In mammalian auditory systems, the spiking characteristics of each primary 
      afferent (type I auditory-nerve fiber; ANF) are mainly determined by a single 
      ribbon synapse in a single receptor cell (inner hair cell; IHC). ANF spike trains 
      therefore provide a window into the operation of these synapses and cells. It was 
      demonstrated previously (Heil et al., 2007) that the distribution of interspike 
      intervals (ISIs) of cat ANFs during spontaneous activity can be modeled as 
      resulting from refractoriness operating on a non-Poisson stochastic point process 
      of excitation (transmitter release events from the IHC). Here, we investigate 
      nonrenewal properties of these cat-ANF spontaneous spike trains, manifest as 
      negative serial ISI correlations and reduced spike-count variability over short 
      timescales. A previously discussed excitatory process, the constrained failure of 
      events from a homogeneous Poisson point process, can account for these 
      properties, but does not offer a parsimonious explanation for certain trends in 
      the data. We then investigate a three-parameter model of vesicle-pool depletion 
      and replenishment and find that it accounts for all experimental observations, 
      including the ISI distributions, with only the release probability varying 
      between spike trains. The maximum number of units (single vesicles or groups of 
      simultaneously released vesicles) in the readily releasable pool and their 
      replenishment time constant can be assumed to be constant ( approximately 4 and 13.5 ms, 
      respectively). We suggest that the organization of the IHC ribbon synapses not 
      only enables sustained release of neurotransmitter but also imposes temporal 
      regularity on the release process, particularly when operating at high rates.
CI  - Copyright (c) 2014 the authors 0270-6474/14/3415097-13$15.00/0.
FAU - Peterson, Adam J
AU  - Peterson AJ
AD  - Leibniz Institute for Neurobiology, 39118 Magdeburg, Germany.
FAU - Irvine, Dexter R F
AU  - Irvine DR
AUID- ORCID: 0000-0002-4397-947X
AD  - School of Psychological Sciences, Monash University, Victoria 3800, Australia, 
      Bionics Institute, East Melbourne, Victoria 3002, Australia, and.
FAU - Heil, Peter
AU  - Heil P
AUID- ORCID: 0000-0001-7861-5927
AD  - Leibniz Institute for Neurobiology, 39118 Magdeburg, Germany, Center for 
      Behavioral Brain Sciences, 39106 Magdeburg, Germany peter.heil@lin-magdeburg.de.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
SB  - IM
MH  - Animals
MH  - Cochlear Nerve/*physiology
MH  - Exocytosis
MH  - *Models, Neurological
MH  - *Synaptic Potentials
MH  - Synaptic Vesicles/*metabolism/physiology
PMC - PMC6608369
OTO - NOTNLM
OT  - Fano factor
OT  - auditory nerve
OT  - interspike interval
OT  - ribbon synapse
OT  - serial correlation
OT  - spontaneous activity
EDAT- 2014/11/08 06:00
MHDA- 2015/01/21 06:00
PMCR- 2015/05/05
CRDT- 2014/11/08 06:00
PHST- 2014/11/08 06:00 [entrez]
PHST- 2014/11/08 06:00 [pubmed]
PHST- 2015/01/21 06:00 [medline]
PHST- 2015/05/05 00:00 [pmc-release]
AID - 34/45/15097 [pii]
AID - 0903-14 [pii]
AID - 10.1523/JNEUROSCI.0903-14.2014 [doi]
PST - ppublish
SO  - J Neurosci. 2014 Nov 5;34(45):15097-109. doi: 10.1523/JNEUROSCI.0903-14.2014.