PMID- 25378636
OWN - NLM
STAT- MEDLINE
DCOM- 20150522
LR  - 20150325
IS  - 1537-6613 (Electronic)
IS  - 0022-1899 (Linking)
VI  - 211
IP  - 8
DP  - 2015 Apr 15
TI  - HIV Nef promotes expression of B-lymphocyte stimulator by blood dendritic cells 
      during HIV infection in humans.
PG  - 1229-40
LID - 10.1093/infdis/jiu611 [doi]
AB  - Dendritic cells (DCs) modulate B-cell survival and differentiation, mainly 
      through production of growth factors such as B lymphocyte stimulator (BLyS; also 
      known as "B-cell factor belonging to the tumor necrosis factor family" [BAFF]). 
      We have recently shown that, in human immunodeficiency virus (HIV)-infected 
      individuals with rapid and those with classic disease progression, B-cell 
      dysregulations were associated with increased BLyS expression in plasma and by 
      blood myeloid DCs (mDCs), in contrast to aviremic HIV-infected individuals with 
      slow disease progression (also known as "elite controllers"). In previous work 
      with transgenic mice expressing HIV genes, B-cell dysregulations were concomitant 
      with altered mDCs and dependent on HIV negative factor (Nef). We now report that 
      HIV Nef is detected early after infection and despite successful therapy in 
      plasma and BLyS-overexpressing blood mDCs of HIV-infected rapid and classic 
      progressors, whereas it is low to undetectable in aviremic slow progressors. In 
      vitro, HIV Nef drives monocyte-derived DCs toward BLyS overexpression through a 
      process involving STAT1. Importantly, this is counteracted in the presence of 
      all-trans retinoic acid. Nef thus contributes to high BLyS proinflammatory 
      profiles in HIV-infected individuals.
CI  - (c) The Author 2014. Published by Oxford University Press on behalf of the 
      Infectious Diseases Society of America. All rights reserved. For Permissions, 
      please e-mail: journals.permissions@oup.com.
FAU - Chagnon-Choquet, Josiane
AU  - Chagnon-Choquet J
AD  - Laboratoire d'immunogenetique, Centre de Recherche du Centre Hospitalier 
      Departement de Microbiologie, Infectiologie et Immunologie, Universite de 
      Montreal, Canada.
FAU - Gauvin, Julie
AU  - Gauvin J
AD  - Laboratoire d'immunogenetique, Centre de Recherche du Centre Hospitalier 
      Departement de Microbiologie, Infectiologie et Immunologie, Universite de 
      Montreal, Canada.
FAU - Roger, Julien
AU  - Roger J
AD  - Laboratoire d'immunogenetique, Centre de Recherche du Centre Hospitalier.
FAU - Fontaine, Julie
AU  - Fontaine J
AD  - Laboratoire d'immunogenetique, Centre de Recherche du Centre Hospitalier 
      Departement de Microbiologie, Infectiologie et Immunologie, Universite de 
      Montreal, Canada.
FAU - Poudrier, Johanne
AU  - Poudrier J
AD  - Laboratoire d'immunogenetique, Centre de Recherche du Centre Hospitalier 
      Departement de Microbiologie, Infectiologie et Immunologie, Universite de 
      Montreal, Canada.
FAU - Roger, Michel
AU  - Roger M
AD  - Laboratoire d'immunogenetique, Centre de Recherche du Centre Hospitalier 
      Departement de Microbiologie, Infectiologie et Immunologie, Universite de 
      Montreal, Canada.
CN  - Montreal Primary HIV Infection and Slow Progressor Study Groups
LA  - eng
GR  - CHR-126633/Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141106
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (B-Cell Activating Factor)
RN  - 0 (STAT1 Transcription Factor)
RN  - 0 (STAT1 protein, human)
RN  - 0 (nef Gene Products, Human Immunodeficiency Virus)
RN  - 5688UTC01R (Tretinoin)
SB  - IM
MH  - Adult
MH  - B-Cell Activating Factor/*metabolism
MH  - B-Lymphocytes/*metabolism
MH  - Dendritic Cells/*metabolism
MH  - Female
MH  - HIV Infections/*metabolism
MH  - HIV-1/*metabolism
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - STAT1 Transcription Factor/metabolism
MH  - Tretinoin/metabolism
MH  - nef Gene Products, Human Immunodeficiency Virus/*metabolism
OTO - NOTNLM
OT  - B lymphocyte stimulator (BLyS/BAFF)
OT  - HIV Nef
OT  - HIV disease control versus progression
OT  - dendritic cells
FIR - Vassal, Anne
IR  - Vassal A
FIR - Legault, Mario
IR  - Legault M
FIR - Routy, Jean Pierre
IR  - Routy JP
FIR - Tremblay, Cecile
IR  - Tremblay C
FIR - Thomas, Rejean
IR  - Thomas R
FIR - Trottier, Benoit
IR  - Trottier B
FIR - Vezina, Sylvie
IR  - Vezina S
FIR - Charest, Louise
IR  - Charest L
FIR - Milne, Catherine
IR  - Milne C
FIR - Friedman, Jason
IR  - Friedman J
FIR - Huchet, Emmanuelle
IR  - Huchet E
FIR - Baril, Jean-Guy
IR  - Baril JG
FIR - Cote, Pierre
IR  - Cote P
FIR - Lessard, Bernard
IR  - Lessard B
FIR - Dufresne, Serge
IR  - Dufresne S
FIR - Charron, Marc-Andre
IR  - Charron MA
FIR - LeBlanc, Roger
IR  - LeBlanc R
FIR - Labrecque, Louise
IR  - Labrecque L
FIR - Rouleau, Danielle
IR  - Rouleau D
FIR - Fortin, Claude
IR  - Fortin C
FIR - Munoz, Marie
IR  - Munoz M
FIR - Bruneau, Julie
IR  - Bruneau J
FIR - Gilmore, Norbert
IR  - Gilmore N
FIR - Lalonde, Richard
IR  - Lalonde R
FIR - Potter, Martin
IR  - Potter M
FIR - Klein, Marina
IR  - Klein M
FIR - de Pokomandy, Alexandra
IR  - de Pokomandy A
FIR - Szabo, Jason
IR  - Szabo J
FIR - Bernard, Nicole
IR  - Bernard N
EDAT- 2014/11/08 06:00
MHDA- 2015/05/23 06:00
CRDT- 2014/11/08 06:00
PHST- 2014/11/08 06:00 [entrez]
PHST- 2014/11/08 06:00 [pubmed]
PHST- 2015/05/23 06:00 [medline]
AID - jiu611 [pii]
AID - 10.1093/infdis/jiu611 [doi]
PST - ppublish
SO  - J Infect Dis. 2015 Apr 15;211(8):1229-40. doi: 10.1093/infdis/jiu611. Epub 2014 
      Nov 6.