PMID- 25378677
OWN - NLM
STAT- MEDLINE
DCOM- 20150310
LR  - 20220129
IS  - 1526-632X (Electronic)
IS  - 0028-3878 (Linking)
VI  - 83
IP  - 23
DP  - 2014 Dec 2
TI  - Changing outcome in inflammatory neuropathies: Rasch-comparative responsiveness.
PG  - 2124-32
LID - 10.1212/WNL.0000000000001044 [doi]
AB  - OBJECTIVES: We performed responsiveness comparison between the patient-reported 
      Inflammatory Rasch-built Overall Disability Scale (I-RODS) and the widely used 
      clinician-reported Inflammatory Neuropathy Cause and Treatment-Overall Neuropathy 
      Limitation Scale (INCAT-ONLS) in patients with Guillain-Barre syndrome (GBS), 
      chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), and 
      immunoglobulin M-monoclonal gammopathy of undetermined significance related 
      polyneuropathy (IgM-MGUSP). METHODS: One hundred thirty-seven patients (GBS: 55, 
      CIDP: 59, IgM-MGUSP: 23) with a new diagnosis or clinical relapse assessed both 
      scales. Patients with GBS/CIDP were examined at 0, 1, 3, 6, and 12 months; 
      patients with IgM-MGUSP at 0, 3, and 12. We subjected all data to Rasch analyses, 
      and calculated for each patient the magnitude of change on both scales using the 
      minimal clinically important difference (MCID) related to the individual standard 
      errors (SEs). A responder was defined as having an MCID-SE >/=1.96. Individual 
      scores on both measures were correlated with the EuroQoL thermometer (heuristic 
      responsiveness). RESULTS: The I-RODS showed a significantly higher proportion of 
      meaningful improvement compared with the INCAT-ONLS findings in GBS/CIDP. For 
      IgM-MGUSP, the lack of responsiveness during the 1-year study did not allow a 
      clear separation. Heuristic responsiveness was consistently higher with the 
      I-RODS. CONCLUSION: The I-RODS more often captures clinically meaningful changes 
      over time, with a greater magnitude of change, compared with the INCAT-ONLS 
      disability scale in patients with GBS and CIDP. The I-RODS offers promise for 
      being a more sensitive measure and its use is therefore suggested in future 
      trials involving patients with GBS and CIDP.
CI  - (c) 2014 American Academy of Neurology.
FAU - Draak, Thomas H P
AU  - Draak TH
AD  - From the Department of Neurology (T.H.P.D., E.K.V., C.G.F., I.S.J.M.), University 
      Medical Centre Maastricht; Department of Neurology (S.I.v.N., P.A.v.D.), Erasmus 
      Medical Centre Rotterdam, the Netherlands; Department of Neurology (K.C.G.), St. 
      Elizabeth's Medical Center, Tufts University School of Medicine, Boston, MA; 
      Department of Neurology (W.L.V.d.P., N.C.N., L.H.v.d.B.), Rudolf Magnus Institute 
      of Neuroscience University Medical Centre Utrecht, the Netherlands; Department of 
      Neurological Sciences (E.N.-O.), Milan University, Humanitas Clinical Institute, 
      Rozzano, Milan, Italy; Department of Neurology (J.M.L.), Hopital de la 
      Salpetriere, Paris, France; Department of Neurology (P.Y.K.V.d.B.), Catholique 
      University of Louvain, Belgium; Department of Clinical Neurosciences (G.L.), 3rd 
      Neurology Unit, Milan, Italy; Department of Neurology (V.B., H.K.), Toronto 
      General Hospital, Canada; Department of Neurology (M.P.T.L.), Centre for 
      Neuromuscular Disease, National Hospital for Neurology and Neurosurgery, Queen 
      Square, London, UK; Department of Neurology (J.P.), Centre de Reference des 
      Maladies Neuromusculaires et de la SLA, Hopital de La Timone, Marseille, France; 
      Department of Neurology (A.J.v.d.K.), Academic Medical Centre, Amsterdam, the 
      Netherlands; Department of Neurology (A.F.H.), London Health Science Center, 
      London, Canada; Department of Neurology (D.R.C.), Johns Hopkins School of 
      Medicine, Baltimore, MD; and Department of Neurology (I.S.J.M.), Spaarne 
      Hospital, Hoofddorp, the Netherlands. tim.draak@mumc.nl.
FAU - Vanhoutte, Els K
AU  - Vanhoutte EK
AD  - From the Department of Neurology (T.H.P.D., E.K.V., C.G.F., I.S.J.M.), University 
      Medical Centre Maastricht; Department of Neurology (S.I.v.N., P.A.v.D.), Erasmus 
      Medical Centre Rotterdam, the Netherlands; Department of Neurology (K.C.G.), St. 
      Elizabeth's Medical Center, Tufts University School of Medicine, Boston, MA; 
      Department of Neurology (W.L.V.d.P., N.C.N., L.H.v.d.B.), Rudolf Magnus Institute 
      of Neuroscience University Medical Centre Utrecht, the Netherlands; Department of 
      Neurological Sciences (E.N.-O.), Milan University, Humanitas Clinical Institute, 
      Rozzano, Milan, Italy; Department of Neurology (J.M.L.), Hopital de la 
      Salpetriere, Paris, France; Department of Neurology (P.Y.K.V.d.B.), Catholique 
      University of Louvain, Belgium; Department of Clinical Neurosciences (G.L.), 3rd 
      Neurology Unit, Milan, Italy; Department of Neurology (V.B., H.K.), Toronto 
      General Hospital, Canada; Department of Neurology (M.P.T.L.), Centre for 
      Neuromuscular Disease, National Hospital for Neurology and Neurosurgery, Queen 
      Square, London, UK; Department of Neurology (J.P.), Centre de Reference des 
      Maladies Neuromusculaires et de la SLA, Hopital de La Timone, Marseille, France; 
      Department of Neurology (A.J.v.d.K.), Academic Medical Centre, Amsterdam, the 
      Netherlands; Department of Neurology (A.F.H.), London Health Science Center, 
      London, Canada; Department of Neurology (D.R.C.), Johns Hopkins School of 
      Medicine, Baltimore, MD; and Department of Neurology (I.S.J.M.), Spaarne 
      Hospital, Hoofddorp, the Netherlands.
FAU - van Nes, Sonja I
AU  - van Nes SI
AD  - From the Department of Neurology (T.H.P.D., E.K.V., C.G.F., I.S.J.M.), University 
      Medical Centre Maastricht; Department of Neurology (S.I.v.N., P.A.v.D.), Erasmus 
      Medical Centre Rotterdam, the Netherlands; Department of Neurology (K.C.G.), St. 
      Elizabeth's Medical Center, Tufts University School of Medicine, Boston, MA; 
      Department of Neurology (W.L.V.d.P., N.C.N., L.H.v.d.B.), Rudolf Magnus Institute 
      of Neuroscience University Medical Centre Utrecht, the Netherlands; Department of 
      Neurological Sciences (E.N.-O.), Milan University, Humanitas Clinical Institute, 
      Rozzano, Milan, Italy; Department of Neurology (J.M.L.), Hopital de la 
      Salpetriere, Paris, France; Department of Neurology (P.Y.K.V.d.B.), Catholique 
      University of Louvain, Belgium; Department of Clinical Neurosciences (G.L.), 3rd 
      Neurology Unit, Milan, Italy; Department of Neurology (V.B., H.K.), Toronto 
      General Hospital, Canada; Department of Neurology (M.P.T.L.), Centre for 
      Neuromuscular Disease, National Hospital for Neurology and Neurosurgery, Queen 
      Square, London, UK; Department of Neurology (J.P.), Centre de Reference des 
      Maladies Neuromusculaires et de la SLA, Hopital de La Timone, Marseille, France; 
      Department of Neurology (A.J.v.d.K.), Academic Medical Centre, Amsterdam, the 
      Netherlands; Department of Neurology (A.F.H.), London Health Science Center, 
      London, Canada; Department of Neurology (D.R.C.), Johns Hopkins School of 
      Medicine, Baltimore, MD; and Department of Neurology (I.S.J.M.), Spaarne 
      Hospital, Hoofddorp, the Netherlands.
FAU - Gorson, Kenneth C
AU  - Gorson KC
AD  - From the Department of Neurology (T.H.P.D., E.K.V., C.G.F., I.S.J.M.), University 
      Medical Centre Maastricht; Department of Neurology (S.I.v.N., P.A.v.D.), Erasmus 
      Medical Centre Rotterdam, the Netherlands; Department of Neurology (K.C.G.), St. 
      Elizabeth's Medical Center, Tufts University School of Medicine, Boston, MA; 
      Department of Neurology (W.L.V.d.P., N.C.N., L.H.v.d.B.), Rudolf Magnus Institute 
      of Neuroscience University Medical Centre Utrecht, the Netherlands; Department of 
      Neurological Sciences (E.N.-O.), Milan University, Humanitas Clinical Institute, 
      Rozzano, Milan, Italy; Department of Neurology (J.M.L.), Hopital de la 
      Salpetriere, Paris, France; Department of Neurology (P.Y.K.V.d.B.), Catholique 
      University of Louvain, Belgium; Department of Clinical Neurosciences (G.L.), 3rd 
      Neurology Unit, Milan, Italy; Department of Neurology (V.B., H.K.), Toronto 
      General Hospital, Canada; Department of Neurology (M.P.T.L.), Centre for 
      Neuromuscular Disease, National Hospital for Neurology and Neurosurgery, Queen 
      Square, London, UK; Department of Neurology (J.P.), Centre de Reference des 
      Maladies Neuromusculaires et de la SLA, Hopital de La Timone, Marseille, France; 
      Department of Neurology (A.J.v.d.K.), Academic Medical Centre, Amsterdam, the 
      Netherlands; Department of Neurology (A.F.H.), London Health Science Center, 
      London, Canada; Department of Neurology (D.R.C.), Johns Hopkins School of 
      Medicine, Baltimore, MD; and Department of Neurology (I.S.J.M.), Spaarne 
      Hospital, Hoofddorp, the Netherlands.
FAU - Van der Pol, W Ludo
AU  - Van der Pol WL
AD  - From the Department of Neurology (T.H.P.D., E.K.V., C.G.F., I.S.J.M.), University 
      Medical Centre Maastricht; Department of Neurology (S.I.v.N., P.A.v.D.), Erasmus 
      Medical Centre Rotterdam, the Netherlands; Department of Neurology (K.C.G.), St. 
      Elizabeth's Medical Center, Tufts University School of Medicine, Boston, MA; 
      Department of Neurology (W.L.V.d.P., N.C.N., L.H.v.d.B.), Rudolf Magnus Institute 
      of Neuroscience University Medical Centre Utrecht, the Netherlands; Department of 
      Neurological Sciences (E.N.-O.), Milan University, Humanitas Clinical Institute, 
      Rozzano, Milan, Italy; Department of Neurology (J.M.L.), Hopital de la 
      Salpetriere, Paris, France; Department of Neurology (P.Y.K.V.d.B.), Catholique 
      University of Louvain, Belgium; Department of Clinical Neurosciences (G.L.), 3rd 
      Neurology Unit, Milan, Italy; Department of Neurology (V.B., H.K.), Toronto 
      General Hospital, Canada; Department of Neurology (M.P.T.L.), Centre for 
      Neuromuscular Disease, National Hospital for Neurology and Neurosurgery, Queen 
      Square, London, UK; Department of Neurology (J.P.), Centre de Reference des 
      Maladies Neuromusculaires et de la SLA, Hopital de La Timone, Marseille, France; 
      Department of Neurology (A.J.v.d.K.), Academic Medical Centre, Amsterdam, the 
      Netherlands; Department of Neurology (A.F.H.), London Health Science Center, 
      London, Canada; Department of Neurology (D.R.C.), Johns Hopkins School of 
      Medicine, Baltimore, MD; and Department of Neurology (I.S.J.M.), Spaarne 
      Hospital, Hoofddorp, the Netherlands.
FAU - Notermans, Nicolette C
AU  - Notermans NC
AD  - From the Department of Neurology (T.H.P.D., E.K.V., C.G.F., I.S.J.M.), University 
      Medical Centre Maastricht; Department of Neurology (S.I.v.N., P.A.v.D.), Erasmus 
      Medical Centre Rotterdam, the Netherlands; Department of Neurology (K.C.G.), St. 
      Elizabeth's Medical Center, Tufts University School of Medicine, Boston, MA; 
      Department of Neurology (W.L.V.d.P., N.C.N., L.H.v.d.B.), Rudolf Magnus Institute 
      of Neuroscience University Medical Centre Utrecht, the Netherlands; Department of 
      Neurological Sciences (E.N.-O.), Milan University, Humanitas Clinical Institute, 
      Rozzano, Milan, Italy; Department of Neurology (J.M.L.), Hopital de la 
      Salpetriere, Paris, France; Department of Neurology (P.Y.K.V.d.B.), Catholique 
      University of Louvain, Belgium; Department of Clinical Neurosciences (G.L.), 3rd 
      Neurology Unit, Milan, Italy; Department of Neurology (V.B., H.K.), Toronto 
      General Hospital, Canada; Department of Neurology (M.P.T.L.), Centre for 
      Neuromuscular Disease, National Hospital for Neurology and Neurosurgery, Queen 
      Square, London, UK; Department of Neurology (J.P.), Centre de Reference des 
      Maladies Neuromusculaires et de la SLA, Hopital de La Timone, Marseille, France; 
      Department of Neurology (A.J.v.d.K.), Academic Medical Centre, Amsterdam, the 
      Netherlands; Department of Neurology (A.F.H.), London Health Science Center, 
      London, Canada; Department of Neurology (D.R.C.), Johns Hopkins School of 
      Medicine, Baltimore, MD; and Department of Neurology (I.S.J.M.), Spaarne 
      Hospital, Hoofddorp, the Netherlands.
FAU - Nobile-Orazio, Eduardo
AU  - Nobile-Orazio E
AD  - From the Department of Neurology (T.H.P.D., E.K.V., C.G.F., I.S.J.M.), University 
      Medical Centre Maastricht; Department of Neurology (S.I.v.N., P.A.v.D.), Erasmus 
      Medical Centre Rotterdam, the Netherlands; Department of Neurology (K.C.G.), St. 
      Elizabeth's Medical Center, Tufts University School of Medicine, Boston, MA; 
      Department of Neurology (W.L.V.d.P., N.C.N., L.H.v.d.B.), Rudolf Magnus Institute 
      of Neuroscience University Medical Centre Utrecht, the Netherlands; Department of 
      Neurological Sciences (E.N.-O.), Milan University, Humanitas Clinical Institute, 
      Rozzano, Milan, Italy; Department of Neurology (J.M.L.), Hopital de la 
      Salpetriere, Paris, France; Department of Neurology (P.Y.K.V.d.B.), Catholique 
      University of Louvain, Belgium; Department of Clinical Neurosciences (G.L.), 3rd 
      Neurology Unit, Milan, Italy; Department of Neurology (V.B., H.K.), Toronto 
      General Hospital, Canada; Department of Neurology (M.P.T.L.), Centre for 
      Neuromuscular Disease, National Hospital for Neurology and Neurosurgery, Queen 
      Square, London, UK; Department of Neurology (J.P.), Centre de Reference des 
      Maladies Neuromusculaires et de la SLA, Hopital de La Timone, Marseille, France; 
      Department of Neurology (A.J.v.d.K.), Academic Medical Centre, Amsterdam, the 
      Netherlands; Department of Neurology (A.F.H.), London Health Science Center, 
      London, Canada; Department of Neurology (D.R.C.), Johns Hopkins School of 
      Medicine, Baltimore, MD; and Department of Neurology (I.S.J.M.), Spaarne 
      Hospital, Hoofddorp, the Netherlands.
FAU - Leger, Jean-Marc
AU  - Leger JM
AD  - From the Department of Neurology (T.H.P.D., E.K.V., C.G.F., I.S.J.M.), University 
      Medical Centre Maastricht; Department of Neurology (S.I.v.N., P.A.v.D.), Erasmus 
      Medical Centre Rotterdam, the Netherlands; Department of Neurology (K.C.G.), St. 
      Elizabeth's Medical Center, Tufts University School of Medicine, Boston, MA; 
      Department of Neurology (W.L.V.d.P., N.C.N., L.H.v.d.B.), Rudolf Magnus Institute 
      of Neuroscience University Medical Centre Utrecht, the Netherlands; Department of 
      Neurological Sciences (E.N.-O.), Milan University, Humanitas Clinical Institute, 
      Rozzano, Milan, Italy; Department of Neurology (J.M.L.), Hopital de la 
      Salpetriere, Paris, France; Department of Neurology (P.Y.K.V.d.B.), Catholique 
      University of Louvain, Belgium; Department of Clinical Neurosciences (G.L.), 3rd 
      Neurology Unit, Milan, Italy; Department of Neurology (V.B., H.K.), Toronto 
      General Hospital, Canada; Department of Neurology (M.P.T.L.), Centre for 
      Neuromuscular Disease, National Hospital for Neurology and Neurosurgery, Queen 
      Square, London, UK; Department of Neurology (J.P.), Centre de Reference des 
      Maladies Neuromusculaires et de la SLA, Hopital de La Timone, Marseille, France; 
      Department of Neurology (A.J.v.d.K.), Academic Medical Centre, Amsterdam, the 
      Netherlands; Department of Neurology (A.F.H.), London Health Science Center, 
      London, Canada; Department of Neurology (D.R.C.), Johns Hopkins School of 
      Medicine, Baltimore, MD; and Department of Neurology (I.S.J.M.), Spaarne 
      Hospital, Hoofddorp, the Netherlands.
FAU - Van den Bergh, Peter Y K
AU  - Van den Bergh PY
AD  - From the Department of Neurology (T.H.P.D., E.K.V., C.G.F., I.S.J.M.), University 
      Medical Centre Maastricht; Department of Neurology (S.I.v.N., P.A.v.D.), Erasmus 
      Medical Centre Rotterdam, the Netherlands; Department of Neurology (K.C.G.), St. 
      Elizabeth's Medical Center, Tufts University School of Medicine, Boston, MA; 
      Department of Neurology (W.L.V.d.P., N.C.N., L.H.v.d.B.), Rudolf Magnus Institute 
      of Neuroscience University Medical Centre Utrecht, the Netherlands; Department of 
      Neurological Sciences (E.N.-O.), Milan University, Humanitas Clinical Institute, 
      Rozzano, Milan, Italy; Department of Neurology (J.M.L.), Hopital de la 
      Salpetriere, Paris, France; Department of Neurology (P.Y.K.V.d.B.), Catholique 
      University of Louvain, Belgium; Department of Clinical Neurosciences (G.L.), 3rd 
      Neurology Unit, Milan, Italy; Department of Neurology (V.B., H.K.), Toronto 
      General Hospital, Canada; Department of Neurology (M.P.T.L.), Centre for 
      Neuromuscular Disease, National Hospital for Neurology and Neurosurgery, Queen 
      Square, London, UK; Department of Neurology (J.P.), Centre de Reference des 
      Maladies Neuromusculaires et de la SLA, Hopital de La Timone, Marseille, France; 
      Department of Neurology (A.J.v.d.K.), Academic Medical Centre, Amsterdam, the 
      Netherlands; Department of Neurology (A.F.H.), London Health Science Center, 
      London, Canada; Department of Neurology (D.R.C.), Johns Hopkins School of 
      Medicine, Baltimore, MD; and Department of Neurology (I.S.J.M.), Spaarne 
      Hospital, Hoofddorp, the Netherlands.
FAU - Lauria, Giuseppe
AU  - Lauria G
AD  - From the Department of Neurology (T.H.P.D., E.K.V., C.G.F., I.S.J.M.), University 
      Medical Centre Maastricht; Department of Neurology (S.I.v.N., P.A.v.D.), Erasmus 
      Medical Centre Rotterdam, the Netherlands; Department of Neurology (K.C.G.), St. 
      Elizabeth's Medical Center, Tufts University School of Medicine, Boston, MA; 
      Department of Neurology (W.L.V.d.P., N.C.N., L.H.v.d.B.), Rudolf Magnus Institute 
      of Neuroscience University Medical Centre Utrecht, the Netherlands; Department of 
      Neurological Sciences (E.N.-O.), Milan University, Humanitas Clinical Institute, 
      Rozzano, Milan, Italy; Department of Neurology (J.M.L.), Hopital de la 
      Salpetriere, Paris, France; Department of Neurology (P.Y.K.V.d.B.), Catholique 
      University of Louvain, Belgium; Department of Clinical Neurosciences (G.L.), 3rd 
      Neurology Unit, Milan, Italy; Department of Neurology (V.B., H.K.), Toronto 
      General Hospital, Canada; Department of Neurology (M.P.T.L.), Centre for 
      Neuromuscular Disease, National Hospital for Neurology and Neurosurgery, Queen 
      Square, London, UK; Department of Neurology (J.P.), Centre de Reference des 
      Maladies Neuromusculaires et de la SLA, Hopital de La Timone, Marseille, France; 
      Department of Neurology (A.J.v.d.K.), Academic Medical Centre, Amsterdam, the 
      Netherlands; Department of Neurology (A.F.H.), London Health Science Center, 
      London, Canada; Department of Neurology (D.R.C.), Johns Hopkins School of 
      Medicine, Baltimore, MD; and Department of Neurology (I.S.J.M.), Spaarne 
      Hospital, Hoofddorp, the Netherlands.
FAU - Bril, Vera
AU  - Bril V
AD  - From the Department of Neurology (T.H.P.D., E.K.V., C.G.F., I.S.J.M.), University 
      Medical Centre Maastricht; Department of Neurology (S.I.v.N., P.A.v.D.), Erasmus 
      Medical Centre Rotterdam, the Netherlands; Department of Neurology (K.C.G.), St. 
      Elizabeth's Medical Center, Tufts University School of Medicine, Boston, MA; 
      Department of Neurology (W.L.V.d.P., N.C.N., L.H.v.d.B.), Rudolf Magnus Institute 
      of Neuroscience University Medical Centre Utrecht, the Netherlands; Department of 
      Neurological Sciences (E.N.-O.), Milan University, Humanitas Clinical Institute, 
      Rozzano, Milan, Italy; Department of Neurology (J.M.L.), Hopital de la 
      Salpetriere, Paris, France; Department of Neurology (P.Y.K.V.d.B.), Catholique 
      University of Louvain, Belgium; Department of Clinical Neurosciences (G.L.), 3rd 
      Neurology Unit, Milan, Italy; Department of Neurology (V.B., H.K.), Toronto 
      General Hospital, Canada; Department of Neurology (M.P.T.L.), Centre for 
      Neuromuscular Disease, National Hospital for Neurology and Neurosurgery, Queen 
      Square, London, UK; Department of Neurology (J.P.), Centre de Reference des 
      Maladies Neuromusculaires et de la SLA, Hopital de La Timone, Marseille, France; 
      Department of Neurology (A.J.v.d.K.), Academic Medical Centre, Amsterdam, the 
      Netherlands; Department of Neurology (A.F.H.), London Health Science Center, 
      London, Canada; Department of Neurology (D.R.C.), Johns Hopkins School of 
      Medicine, Baltimore, MD; and Department of Neurology (I.S.J.M.), Spaarne 
      Hospital, Hoofddorp, the Netherlands.
FAU - Katzberg, Hans
AU  - Katzberg H
AD  - From the Department of Neurology (T.H.P.D., E.K.V., C.G.F., I.S.J.M.), University 
      Medical Centre Maastricht; Department of Neurology (S.I.v.N., P.A.v.D.), Erasmus 
      Medical Centre Rotterdam, the Netherlands; Department of Neurology (K.C.G.), St. 
      Elizabeth's Medical Center, Tufts University School of Medicine, Boston, MA; 
      Department of Neurology (W.L.V.d.P., N.C.N., L.H.v.d.B.), Rudolf Magnus Institute 
      of Neuroscience University Medical Centre Utrecht, the Netherlands; Department of 
      Neurological Sciences (E.N.-O.), Milan University, Humanitas Clinical Institute, 
      Rozzano, Milan, Italy; Department of Neurology (J.M.L.), Hopital de la 
      Salpetriere, Paris, France; Department of Neurology (P.Y.K.V.d.B.), Catholique 
      University of Louvain, Belgium; Department of Clinical Neurosciences (G.L.), 3rd 
      Neurology Unit, Milan, Italy; Department of Neurology (V.B., H.K.), Toronto 
      General Hospital, Canada; Department of Neurology (M.P.T.L.), Centre for 
      Neuromuscular Disease, National Hospital for Neurology and Neurosurgery, Queen 
      Square, London, UK; Department of Neurology (J.P.), Centre de Reference des 
      Maladies Neuromusculaires et de la SLA, Hopital de La Timone, Marseille, France; 
      Department of Neurology (A.J.v.d.K.), Academic Medical Centre, Amsterdam, the 
      Netherlands; Department of Neurology (A.F.H.), London Health Science Center, 
      London, Canada; Department of Neurology (D.R.C.), Johns Hopkins School of 
      Medicine, Baltimore, MD; and Department of Neurology (I.S.J.M.), Spaarne 
      Hospital, Hoofddorp, the Netherlands.
FAU - Lunn, Michael P T
AU  - Lunn MP
AD  - From the Department of Neurology (T.H.P.D., E.K.V., C.G.F., I.S.J.M.), University 
      Medical Centre Maastricht; Department of Neurology (S.I.v.N., P.A.v.D.), Erasmus 
      Medical Centre Rotterdam, the Netherlands; Department of Neurology (K.C.G.), St. 
      Elizabeth's Medical Center, Tufts University School of Medicine, Boston, MA; 
      Department of Neurology (W.L.V.d.P., N.C.N., L.H.v.d.B.), Rudolf Magnus Institute 
      of Neuroscience University Medical Centre Utrecht, the Netherlands; Department of 
      Neurological Sciences (E.N.-O.), Milan University, Humanitas Clinical Institute, 
      Rozzano, Milan, Italy; Department of Neurology (J.M.L.), Hopital de la 
      Salpetriere, Paris, France; Department of Neurology (P.Y.K.V.d.B.), Catholique 
      University of Louvain, Belgium; Department of Clinical Neurosciences (G.L.), 3rd 
      Neurology Unit, Milan, Italy; Department of Neurology (V.B., H.K.), Toronto 
      General Hospital, Canada; Department of Neurology (M.P.T.L.), Centre for 
      Neuromuscular Disease, National Hospital for Neurology and Neurosurgery, Queen 
      Square, London, UK; Department of Neurology (J.P.), Centre de Reference des 
      Maladies Neuromusculaires et de la SLA, Hopital de La Timone, Marseille, France; 
      Department of Neurology (A.J.v.d.K.), Academic Medical Centre, Amsterdam, the 
      Netherlands; Department of Neurology (A.F.H.), London Health Science Center, 
      London, Canada; Department of Neurology (D.R.C.), Johns Hopkins School of 
      Medicine, Baltimore, MD; and Department of Neurology (I.S.J.M.), Spaarne 
      Hospital, Hoofddorp, the Netherlands.
FAU - Pouget, Jean
AU  - Pouget J
AD  - From the Department of Neurology (T.H.P.D., E.K.V., C.G.F., I.S.J.M.), University 
      Medical Centre Maastricht; Department of Neurology (S.I.v.N., P.A.v.D.), Erasmus 
      Medical Centre Rotterdam, the Netherlands; Department of Neurology (K.C.G.), St. 
      Elizabeth's Medical Center, Tufts University School of Medicine, Boston, MA; 
      Department of Neurology (W.L.V.d.P., N.C.N., L.H.v.d.B.), Rudolf Magnus Institute 
      of Neuroscience University Medical Centre Utrecht, the Netherlands; Department of 
      Neurological Sciences (E.N.-O.), Milan University, Humanitas Clinical Institute, 
      Rozzano, Milan, Italy; Department of Neurology (J.M.L.), Hopital de la 
      Salpetriere, Paris, France; Department of Neurology (P.Y.K.V.d.B.), Catholique 
      University of Louvain, Belgium; Department of Clinical Neurosciences (G.L.), 3rd 
      Neurology Unit, Milan, Italy; Department of Neurology (V.B., H.K.), Toronto 
      General Hospital, Canada; Department of Neurology (M.P.T.L.), Centre for 
      Neuromuscular Disease, National Hospital for Neurology and Neurosurgery, Queen 
      Square, London, UK; Department of Neurology (J.P.), Centre de Reference des 
      Maladies Neuromusculaires et de la SLA, Hopital de La Timone, Marseille, France; 
      Department of Neurology (A.J.v.d.K.), Academic Medical Centre, Amsterdam, the 
      Netherlands; Department of Neurology (A.F.H.), London Health Science Center, 
      London, Canada; Department of Neurology (D.R.C.), Johns Hopkins School of 
      Medicine, Baltimore, MD; and Department of Neurology (I.S.J.M.), Spaarne 
      Hospital, Hoofddorp, the Netherlands.
FAU - van der Kooi, Anneke J
AU  - van der Kooi AJ
AD  - From the Department of Neurology (T.H.P.D., E.K.V., C.G.F., I.S.J.M.), University 
      Medical Centre Maastricht; Department of Neurology (S.I.v.N., P.A.v.D.), Erasmus 
      Medical Centre Rotterdam, the Netherlands; Department of Neurology (K.C.G.), St. 
      Elizabeth's Medical Center, Tufts University School of Medicine, Boston, MA; 
      Department of Neurology (W.L.V.d.P., N.C.N., L.H.v.d.B.), Rudolf Magnus Institute 
      of Neuroscience University Medical Centre Utrecht, the Netherlands; Department of 
      Neurological Sciences (E.N.-O.), Milan University, Humanitas Clinical Institute, 
      Rozzano, Milan, Italy; Department of Neurology (J.M.L.), Hopital de la 
      Salpetriere, Paris, France; Department of Neurology (P.Y.K.V.d.B.), Catholique 
      University of Louvain, Belgium; Department of Clinical Neurosciences (G.L.), 3rd 
      Neurology Unit, Milan, Italy; Department of Neurology (V.B., H.K.), Toronto 
      General Hospital, Canada; Department of Neurology (M.P.T.L.), Centre for 
      Neuromuscular Disease, National Hospital for Neurology and Neurosurgery, Queen 
      Square, London, UK; Department of Neurology (J.P.), Centre de Reference des 
      Maladies Neuromusculaires et de la SLA, Hopital de La Timone, Marseille, France; 
      Department of Neurology (A.J.v.d.K.), Academic Medical Centre, Amsterdam, the 
      Netherlands; Department of Neurology (A.F.H.), London Health Science Center, 
      London, Canada; Department of Neurology (D.R.C.), Johns Hopkins School of 
      Medicine, Baltimore, MD; and Department of Neurology (I.S.J.M.), Spaarne 
      Hospital, Hoofddorp, the Netherlands.
FAU - Hahn, Angelika F
AU  - Hahn AF
AD  - From the Department of Neurology (T.H.P.D., E.K.V., C.G.F., I.S.J.M.), University 
      Medical Centre Maastricht; Department of Neurology (S.I.v.N., P.A.v.D.), Erasmus 
      Medical Centre Rotterdam, the Netherlands; Department of Neurology (K.C.G.), St. 
      Elizabeth's Medical Center, Tufts University School of Medicine, Boston, MA; 
      Department of Neurology (W.L.V.d.P., N.C.N., L.H.v.d.B.), Rudolf Magnus Institute 
      of Neuroscience University Medical Centre Utrecht, the Netherlands; Department of 
      Neurological Sciences (E.N.-O.), Milan University, Humanitas Clinical Institute, 
      Rozzano, Milan, Italy; Department of Neurology (J.M.L.), Hopital de la 
      Salpetriere, Paris, France; Department of Neurology (P.Y.K.V.d.B.), Catholique 
      University of Louvain, Belgium; Department of Clinical Neurosciences (G.L.), 3rd 
      Neurology Unit, Milan, Italy; Department of Neurology (V.B., H.K.), Toronto 
      General Hospital, Canada; Department of Neurology (M.P.T.L.), Centre for 
      Neuromuscular Disease, National Hospital for Neurology and Neurosurgery, Queen 
      Square, London, UK; Department of Neurology (J.P.), Centre de Reference des 
      Maladies Neuromusculaires et de la SLA, Hopital de La Timone, Marseille, France; 
      Department of Neurology (A.J.v.d.K.), Academic Medical Centre, Amsterdam, the 
      Netherlands; Department of Neurology (A.F.H.), London Health Science Center, 
      London, Canada; Department of Neurology (D.R.C.), Johns Hopkins School of 
      Medicine, Baltimore, MD; and Department of Neurology (I.S.J.M.), Spaarne 
      Hospital, Hoofddorp, the Netherlands.
FAU - Doorn, Pieter A van
AU  - Doorn PA
AD  - From the Department of Neurology (T.H.P.D., E.K.V., C.G.F., I.S.J.M.), University 
      Medical Centre Maastricht; Department of Neurology (S.I.v.N., P.A.v.D.), Erasmus 
      Medical Centre Rotterdam, the Netherlands; Department of Neurology (K.C.G.), St. 
      Elizabeth's Medical Center, Tufts University School of Medicine, Boston, MA; 
      Department of Neurology (W.L.V.d.P., N.C.N., L.H.v.d.B.), Rudolf Magnus Institute 
      of Neuroscience University Medical Centre Utrecht, the Netherlands; Department of 
      Neurological Sciences (E.N.-O.), Milan University, Humanitas Clinical Institute, 
      Rozzano, Milan, Italy; Department of Neurology (J.M.L.), Hopital de la 
      Salpetriere, Paris, France; Department of Neurology (P.Y.K.V.d.B.), Catholique 
      University of Louvain, Belgium; Department of Clinical Neurosciences (G.L.), 3rd 
      Neurology Unit, Milan, Italy; Department of Neurology (V.B., H.K.), Toronto 
      General Hospital, Canada; Department of Neurology (M.P.T.L.), Centre for 
      Neuromuscular Disease, National Hospital for Neurology and Neurosurgery, Queen 
      Square, London, UK; Department of Neurology (J.P.), Centre de Reference des 
      Maladies Neuromusculaires et de la SLA, Hopital de La Timone, Marseille, France; 
      Department of Neurology (A.J.v.d.K.), Academic Medical Centre, Amsterdam, the 
      Netherlands; Department of Neurology (A.F.H.), London Health Science Center, 
      London, Canada; Department of Neurology (D.R.C.), Johns Hopkins School of 
      Medicine, Baltimore, MD; and Department of Neurology (I.S.J.M.), Spaarne 
      Hospital, Hoofddorp, the Netherlands.
FAU - Cornblath, David R
AU  - Cornblath DR
AD  - From the Department of Neurology (T.H.P.D., E.K.V., C.G.F., I.S.J.M.), University 
      Medical Centre Maastricht; Department of Neurology (S.I.v.N., P.A.v.D.), Erasmus 
      Medical Centre Rotterdam, the Netherlands; Department of Neurology (K.C.G.), St. 
      Elizabeth's Medical Center, Tufts University School of Medicine, Boston, MA; 
      Department of Neurology (W.L.V.d.P., N.C.N., L.H.v.d.B.), Rudolf Magnus Institute 
      of Neuroscience University Medical Centre Utrecht, the Netherlands; Department of 
      Neurological Sciences (E.N.-O.), Milan University, Humanitas Clinical Institute, 
      Rozzano, Milan, Italy; Department of Neurology (J.M.L.), Hopital de la 
      Salpetriere, Paris, France; Department of Neurology (P.Y.K.V.d.B.), Catholique 
      University of Louvain, Belgium; Department of Clinical Neurosciences (G.L.), 3rd 
      Neurology Unit, Milan, Italy; Department of Neurology (V.B., H.K.), Toronto 
      General Hospital, Canada; Department of Neurology (M.P.T.L.), Centre for 
      Neuromuscular Disease, National Hospital for Neurology and Neurosurgery, Queen 
      Square, London, UK; Department of Neurology (J.P.), Centre de Reference des 
      Maladies Neuromusculaires et de la SLA, Hopital de La Timone, Marseille, France; 
      Department of Neurology (A.J.v.d.K.), Academic Medical Centre, Amsterdam, the 
      Netherlands; Department of Neurology (A.F.H.), London Health Science Center, 
      London, Canada; Department of Neurology (D.R.C.), Johns Hopkins School of 
      Medicine, Baltimore, MD; and Department of Neurology (I.S.J.M.), Spaarne 
      Hospital, Hoofddorp, the Netherlands.
FAU - van den Berg, Leonard H
AU  - van den Berg LH
AD  - From the Department of Neurology (T.H.P.D., E.K.V., C.G.F., I.S.J.M.), University 
      Medical Centre Maastricht; Department of Neurology (S.I.v.N., P.A.v.D.), Erasmus 
      Medical Centre Rotterdam, the Netherlands; Department of Neurology (K.C.G.), St. 
      Elizabeth's Medical Center, Tufts University School of Medicine, Boston, MA; 
      Department of Neurology (W.L.V.d.P., N.C.N., L.H.v.d.B.), Rudolf Magnus Institute 
      of Neuroscience University Medical Centre Utrecht, the Netherlands; Department of 
      Neurological Sciences (E.N.-O.), Milan University, Humanitas Clinical Institute, 
      Rozzano, Milan, Italy; Department of Neurology (J.M.L.), Hopital de la 
      Salpetriere, Paris, France; Department of Neurology (P.Y.K.V.d.B.), Catholique 
      University of Louvain, Belgium; Department of Clinical Neurosciences (G.L.), 3rd 
      Neurology Unit, Milan, Italy; Department of Neurology (V.B., H.K.), Toronto 
      General Hospital, Canada; Department of Neurology (M.P.T.L.), Centre for 
      Neuromuscular Disease, National Hospital for Neurology and Neurosurgery, Queen 
      Square, London, UK; Department of Neurology (J.P.), Centre de Reference des 
      Maladies Neuromusculaires et de la SLA, Hopital de La Timone, Marseille, France; 
      Department of Neurology (A.J.v.d.K.), Academic Medical Centre, Amsterdam, the 
      Netherlands; Department of Neurology (A.F.H.), London Health Science Center, 
      London, Canada; Department of Neurology (D.R.C.), Johns Hopkins School of 
      Medicine, Baltimore, MD; and Department of Neurology (I.S.J.M.), Spaarne 
      Hospital, Hoofddorp, the Netherlands.
FAU - Faber, Catharina G
AU  - Faber CG
AD  - From the Department of Neurology (T.H.P.D., E.K.V., C.G.F., I.S.J.M.), University 
      Medical Centre Maastricht; Department of Neurology (S.I.v.N., P.A.v.D.), Erasmus 
      Medical Centre Rotterdam, the Netherlands; Department of Neurology (K.C.G.), St. 
      Elizabeth's Medical Center, Tufts University School of Medicine, Boston, MA; 
      Department of Neurology (W.L.V.d.P., N.C.N., L.H.v.d.B.), Rudolf Magnus Institute 
      of Neuroscience University Medical Centre Utrecht, the Netherlands; Department of 
      Neurological Sciences (E.N.-O.), Milan University, Humanitas Clinical Institute, 
      Rozzano, Milan, Italy; Department of Neurology (J.M.L.), Hopital de la 
      Salpetriere, Paris, France; Department of Neurology (P.Y.K.V.d.B.), Catholique 
      University of Louvain, Belgium; Department of Clinical Neurosciences (G.L.), 3rd 
      Neurology Unit, Milan, Italy; Department of Neurology (V.B., H.K.), Toronto 
      General Hospital, Canada; Department of Neurology (M.P.T.L.), Centre for 
      Neuromuscular Disease, National Hospital for Neurology and Neurosurgery, Queen 
      Square, London, UK; Department of Neurology (J.P.), Centre de Reference des 
      Maladies Neuromusculaires et de la SLA, Hopital de La Timone, Marseille, France; 
      Department of Neurology (A.J.v.d.K.), Academic Medical Centre, Amsterdam, the 
      Netherlands; Department of Neurology (A.F.H.), London Health Science Center, 
      London, Canada; Department of Neurology (D.R.C.), Johns Hopkins School of 
      Medicine, Baltimore, MD; and Department of Neurology (I.S.J.M.), Spaarne 
      Hospital, Hoofddorp, the Netherlands.
FAU - Merkies, Ingemar S J
AU  - Merkies IS
AD  - From the Department of Neurology (T.H.P.D., E.K.V., C.G.F., I.S.J.M.), University 
      Medical Centre Maastricht; Department of Neurology (S.I.v.N., P.A.v.D.), Erasmus 
      Medical Centre Rotterdam, the Netherlands; Department of Neurology (K.C.G.), St. 
      Elizabeth's Medical Center, Tufts University School of Medicine, Boston, MA; 
      Department of Neurology (W.L.V.d.P., N.C.N., L.H.v.d.B.), Rudolf Magnus Institute 
      of Neuroscience University Medical Centre Utrecht, the Netherlands; Department of 
      Neurological Sciences (E.N.-O.), Milan University, Humanitas Clinical Institute, 
      Rozzano, Milan, Italy; Department of Neurology (J.M.L.), Hopital de la 
      Salpetriere, Paris, France; Department of Neurology (P.Y.K.V.d.B.), Catholique 
      University of Louvain, Belgium; Department of Clinical Neurosciences (G.L.), 3rd 
      Neurology Unit, Milan, Italy; Department of Neurology (V.B., H.K.), Toronto 
      General Hospital, Canada; Department of Neurology (M.P.T.L.), Centre for 
      Neuromuscular Disease, National Hospital for Neurology and Neurosurgery, Queen 
      Square, London, UK; Department of Neurology (J.P.), Centre de Reference des 
      Maladies Neuromusculaires et de la SLA, Hopital de La Timone, Marseille, France; 
      Department of Neurology (A.J.v.d.K.), Academic Medical Centre, Amsterdam, the 
      Netherlands; Department of Neurology (A.F.H.), London Health Science Center, 
      London, Canada; Department of Neurology (D.R.C.), Johns Hopkins School of 
      Medicine, Baltimore, MD; and Department of Neurology (I.S.J.M.), Spaarne 
      Hospital, Hoofddorp, the Netherlands.
CN  - PeriNomS Study Group
LA  - eng
GR  - MR/K000608/1/MRC_/Medical Research Council/United Kingdom
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20141105
PL  - United States
TA  - Neurology
JT  - Neurology
JID - 0401060
RN  - 0 (Immunoglobulin M)
SB  - IM
CIN - Neurology. 2014 Dec 2;83(23):2104-5. PMID: 25378676
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Guillain-Barre Syndrome/*physiopathology
MH  - Humans
MH  - Immunoglobulin M/metabolism
MH  - Male
MH  - Middle Aged
MH  - Polyneuropathies/*diagnosis/physiopathology
MH  - Polyradiculoneuropathy, Chronic Inflammatory Demyelinating/*physiopathology
MH  - Severity of Illness Index
MH  - Time Factors
EDAT- 2014/11/08 06:00
MHDA- 2015/03/11 06:00
CRDT- 2014/11/08 06:00
PHST- 2014/11/08 06:00 [entrez]
PHST- 2014/11/08 06:00 [pubmed]
PHST- 2015/03/11 06:00 [medline]
AID - WNL.0000000000001044 [pii]
AID - 10.1212/WNL.0000000000001044 [doi]
PST - ppublish
SO  - Neurology. 2014 Dec 2;83(23):2124-32. doi: 10.1212/WNL.0000000000001044. Epub 
      2014 Nov 5.