PMID- 25379974
OWN - NLM
STAT- MEDLINE
DCOM- 20150421
LR  - 20181202
IS  - 1752-7163 (Electronic)
IS  - 1752-7155 (Linking)
VI  - 8
IP  - 4
DP  - 2014 Nov 7
TI  - E-cadherin as an epithelial barrier protein in exhaled breath condensate.
PG  - 046006
LID - 10.1088/1752-7155/8/4/046006 [doi]
AB  - Airway epithelium plays an important role as a physical barrier and a modulator 
      of allergic response. Junctions between cells provide epithelial integrity and 
      barrier function. The aim of this study was to investigate the influence of atopy 
      on airway epithelial integrity in asthma and to measure E-cadherin levels in 
      exhaled breath condensate as an indicator epithelial damage. A total of 74 
      patients with asthma (35 atopic and 39 non-atopic) and 39 healthy children were 
      enrolled in this case-control study. Sociodemographic characteristics and asthma 
      severity parameters in the last three-month period were recorded and pulmonary 
      function tests were performed. Blood samples were obtained to measure serum 
      immunoglobulin E (IgE) levels and peripheral blood eosinophil count, and exhaled 
      breath condensate (EBC) was obtained to measure E-cadherin.EBC E-cadherin levels 
      were significantly lower in the asthmatics when compared to non-atopic controls 
      (0.109 (0.076) versus 0.191 (0.184) ng mL(-1) respectively, p = 0.01). Atopic and 
      non-atopic asthmatic groups had lower EBC E-cadherin levels compared to the 
      control group. (0.112 (0.060) ng ml(-1), 0.106 (0.089) ng ml(-1) and 0.191 
      (0.184) ng ml(-1), p = 0.02 and p < 0.01 respectively). However, EBC E-cadherin 
      levels were not different between atopic and non-atopic asthmatics. The results 
      of our study support the role of E-cadherin in the pathogenesis of asthma. 
      However, the absence of difference in E-cadherin levels between atopic and 
      non-atopic asthmatics suggests that allergic sensitization is not the primary 
      factor for development of epithelial barrier dysfunction in asthma.
FAU - Yuksel, Hasan
AU  - Yuksel H
AD  - Celal Bayar University Medical Faculty, Dept of Pediatric Allergy and 
      Pulmonology, Manisa, Turkey.
FAU - Turkeli, Ahmet
AU  - Turkeli A
FAU - Taneli, Fatma
AU  - Taneli F
FAU - Horasan, Gonul Dinc
AU  - Horasan GD
FAU - Kanik, Esra Toprak
AU  - Kanik ET
FAU - Kizilkaya, Metehan
AU  - Kizilkaya M
FAU - Gozukara, Ceyhun
AU  - Gozukara C
FAU - Yilmaz, Ozge
AU  - Yilmaz O
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141107
PL  - England
TA  - J Breath Res
JT  - Journal of breath research
JID - 101463871
RN  - 0 (Antigens, CD)
RN  - 0 (CDH1 protein, human)
RN  - 0 (Cadherins)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Antigens, CD
MH  - Asthma/*metabolism/physiopathology
MH  - Breath Tests/methods
MH  - Cadherins/*metabolism
MH  - Case-Control Studies
MH  - Child
MH  - Demography
MH  - Eosinophils
MH  - Epithelium/*metabolism/physiopathology
MH  - *Exhalation
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Leukocyte Count
MH  - Male
MH  - Respiratory Function Tests
EDAT- 2014/11/08 06:00
MHDA- 2015/04/22 06:00
CRDT- 2014/11/08 06:00
PHST- 2014/11/08 06:00 [entrez]
PHST- 2014/11/08 06:00 [pubmed]
PHST- 2015/04/22 06:00 [medline]
AID - 10.1088/1752-7155/8/4/046006 [doi]
PST - epublish
SO  - J Breath Res. 2014 Nov 7;8(4):046006. doi: 10.1088/1752-7155/8/4/046006.