PMID- 25380927
OWN - NLM
STAT- MEDLINE
DCOM- 20151021
LR  - 20181202
IS  - 1873-2623 (Electronic)
IS  - 0041-1345 (Linking)
VI  - 46
IP  - 8
DP  - 2014 Oct
TI  - Role of 16-multidetector computerized tomography in evaluation of graft failure 
      risk in patients with pancreatic graft thrombosis after simultaneous pancreas and 
      kidney transplantation.
PG  - 2822-4
LID - S0041-1345(14)00868-9 [pii]
LID - 10.1016/j.transproceed.2014.09.073 [doi]
AB  - BACKGROUND: Thrombosis of the pancreatic graft vessels is a common complication 
      in patients after pancreas transplantation. The aim of this study was to evaluate 
      the usefulness of 16-multidetector computerized tomography (16-MDCT) with volume 
      rendering (VR) and maximum intensity projection (MIP) reconstruction as a 
      predicting method of pancreatic graft loss after simultaneous pancreas and kidney 
      transplantation. METHODS: Within 6-8 days after combined kidney-pancreas 
      transplantation, MDCT was performed in 60 patients. Secondary reconstructions 
      were obtained with the application of VR and MIP algorithms. Vessel anastomosis, 
      extra- and intrapancreatic arteries, venous morphology, and enhancement of 
      graft's parenchyma were evaluated. The stenosis grade of pancreatic graft vessels 
      and the areas of graft parenchyma malperfusion were evaluated. RESULTS: 
      Thrombosis of pancreatic graft vessels was recognized in 26 patients (43%), 
      however only one-half of them required graftectomy. There were 17 cases of large 
      vessel thrombosis and 9 cases of small intragraft vessel thrombosis. In 13 
      (86.6%) out of 15 recipients parenchymal malperfusion resulted in graft lost. It 
      appeared that vessel narrowing >40% was a threshold for pancreatic graft loss 
      with sensitivity and false positive values of 100% and 9%, respectively. For 
      parenchyma nonenhancement >60% the sensitivity and false positive values of 100% 
      and 0% were significantly associated with pancreatic graft loss (P < .0001). 
      CONCLUSIONS: Vascular occlusion of >40% and necrosis >60% of parenchymal volume 
      correspond with pancreatic graft loss.
FAU - Grabowska-Derlatka, L
AU  - Grabowska-Derlatka L
AD  - 2nd Department of Clinical Radiology, Warsaw Medical University, Warsaw, Poland. 
      Electronic address: larettagrabowska@gmail.com.
FAU - Grochowiecki, T
AU  - Grochowiecki T
AD  - Department of General, Vascular, and Transplant Surgery, Warsaw Medical 
      University, Warsaw, Poland.
FAU - Pacho, R
AU  - Pacho R
AD  - 2nd Department of Clinical Radiology, Warsaw Medical University, Warsaw, Poland.
FAU - Rowinski, O
AU  - Rowinski O
AD  - 2nd Department of Clinical Radiology, Warsaw Medical University, Warsaw, Poland.
FAU - Szmidt, J
AU  - Szmidt J
AD  - Department of General, Vascular, and Transplant Surgery, Warsaw Medical 
      University, Warsaw, Poland.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Transplant Proc
JT  - Transplantation proceedings
JID - 0243532
SB  - IM
MH  - Adult
MH  - Female
MH  - Graft Survival
MH  - Humans
MH  - *Kidney Transplantation
MH  - Male
MH  - Middle Aged
MH  - Multidetector Computed Tomography
MH  - Pancreas/*blood supply/diagnostic imaging
MH  - *Pancreas Transplantation
MH  - Postoperative Complications/diagnosis/*diagnostic imaging
MH  - Prognosis
MH  - Risk
MH  - Risk Assessment
MH  - Sensitivity and Specificity
MH  - Thrombosis/diagnosis/*diagnostic imaging
EDAT- 2014/11/09 06:00
MHDA- 2015/10/22 06:00
CRDT- 2014/11/09 06:00
PHST- 2014/11/09 06:00 [entrez]
PHST- 2014/11/09 06:00 [pubmed]
PHST- 2015/10/22 06:00 [medline]
AID - S0041-1345(14)00868-9 [pii]
AID - 10.1016/j.transproceed.2014.09.073 [doi]
PST - ppublish
SO  - Transplant Proc. 2014 Oct;46(8):2822-4. doi: 10.1016/j.transproceed.2014.09.073.