PMID- 2538104
OWN - NLM
STAT- MEDLINE
DCOM- 19890417
LR  - 20190503
IS  - 0003-4967 (Print)
IS  - 1468-2060 (Electronic)
IS  - 0003-4967 (Linking)
VI  - 48
IP  - 1
DP  - 1989 Jan
TI  - Inhibition of polymorphonuclear leucocyte functions in vivo by Yersinia 
      enterocolitica lipopolysaccharide.
PG  - 42-7
AB  - A single intravenous injection of 5 micrograms of Yersinia enterocolitica 
      lipopolysaccharide (LPS) inhibits rabbit polymorphonuclear leucocyte (PMN) 
      chemotaxis, enzyme secretion, and respiratory burst activation in response to 
      partially purified rabbit C5a and leucotriene B4 (LTB4). Respiratory burst 
      activation is also inhibited in response to platelet activating factor (PAF). In 
      contrast, all these responses to n-formyl-methionyl-leucyl-phenylalanine (FMLP) 
      remain unaltered. This LPS does not modulate PMN activation in vitro or activate 
      the respiratory burst. Thus Y enterocolitica LPS acts in vivo by inhibiting PMN 
      responses to endogenous mediators of inflammation. This inhibition presumably 
      impairs the elimination of pathogens and might, therefore, provide favourable 
      conditions for induction by bacteria of further immunological consequences.
FAU - Hartiala, K T
AU  - Hartiala KT
AD  - Department of Medical Microbiology, University of Turku, Finland.
FAU - Granberg, I
AU  - Granberg I
FAU - Toivanen, A
AU  - Toivanen A
FAU - Viljanen, M
AU  - Viljanen M
LA  - eng
GR  - 5 NO1 RO1 AM 33311/AM/NIADDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Ann Rheum Dis
JT  - Annals of the rheumatic diseases
JID - 0372355
RN  - 0 (Lipopolysaccharides)
RN  - EC 1.11.1.7 (Peroxidase)
SB  - IM
MH  - Animals
MH  - Chemotaxis, Leukocyte/drug effects
MH  - Female
MH  - Lipopolysaccharides/immunology/*pharmacology
MH  - Luminescent Measurements
MH  - Male
MH  - Neutrophils/*drug effects/enzymology
MH  - Peroxidase/metabolism
MH  - Rabbits
MH  - *Yersinia enterocolitica
PMC - PMC1003673
EDAT- 1989/01/01 00:00
MHDA- 1989/01/01 00:01
PMCR- 1992/01/01
CRDT- 1989/01/01 00:00
PHST- 1989/01/01 00:00 [pubmed]
PHST- 1989/01/01 00:01 [medline]
PHST- 1989/01/01 00:00 [entrez]
PHST- 1992/01/01 00:00 [pmc-release]
AID - 10.1136/ard.48.1.42 [doi]
PST - ppublish
SO  - Ann Rheum Dis. 1989 Jan;48(1):42-7. doi: 10.1136/ard.48.1.42.