PMID- 25382027
OWN - NLM
STAT- MEDLINE
DCOM- 20151021
LR  - 20220318
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 4
DP  - 2014 Nov 10
TI  - Association of HLA-DR4/HLA-DRB1*04 with Vogt-Koyanagi-Harada disease: a 
      systematic review and meta-analysis.
PG  - 6887
LID - 10.1038/srep06887 [doi]
LID - 6887
AB  - Human leukocyte antigen (HLA)-DR4/HLA-DRB1*04 has been reported to be a risk 
      factor for Vogt-Koyanagi-Harada disease (VKH) with various strength of 
      association. Its sub-alleles were also found to be associated with VKH. However 
      the results were inconsistent. In this study, we systematically searched the 
      related literature, pooled the odds ratios (ORs) and 95% confidence interval (CI) 
      of association of HLA-DR4/HLA-DRB1*04 or its sub-alleles with VKH from individual 
      studies, and explored the potential source of heterogeneity. A total of 1853 VKH 
      patients and 4164 controls from 21 articles were included in this meta-analysis. 
      The pooled OR of association of HLA-DR4/HLA-DRB1*04 and VKH was 8.42 (95% CI: 
      5.69-12.45). There were significant heterogeneity (I(2) = 71%). Subgroup analysis 
      indicated that ethnicity was the source of heterogeneity (all I(2) = 0, ORs 
      ranged from 2.09-13.69 in subgroups). The sub-alleles, HLA-DRB1*0404 (OR = 2.57), 
      0405 (OR = 10.31) and 0410 (OR = 6.52) increased the risk of VKH; 0401 (OR = 
      0.21) protected VKH; while other sub-alleles were not associated with VKH. Our 
      meta-analysis confirmed the association between VKH and HLA-DR4/DRB1*04, found 
      the strength of association is different in different ethnic groups, and 
      identified HLA-DRB1*0404, 0405 and 0410 as risk sub-alleles while 0401 as 
      protective sub-allele.
FAU - Shi, Tingkun
AU  - Shi T
AD  - Joint Shantou International Eye Center, Shantou University &the Chinese 
      University of Hong Kong.
FAU - Lv, Wenjuan
AU  - Lv W
AD  - Joint Shantou International Eye Center, Shantou University &the Chinese 
      University of Hong Kong.
FAU - Zhang, Li
AU  - Zhang L
AD  - Joint Shantou International Eye Center, Shantou University &the Chinese 
      University of Hong Kong.
FAU - Chen, Jianhuan
AU  - Chen J
AD  - Joint Shantou International Eye Center, Shantou University &the Chinese 
      University of Hong Kong.
FAU - Chen, Haoyu
AU  - Chen H
AD  - Joint Shantou International Eye Center, Shantou University &the Chinese 
      University of Hong Kong.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PT  - Systematic Review
DEP - 20141110
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (HLA-DR4 Antigen)
SB  - IM
MH  - Alleles
MH  - Case-Control Studies
MH  - *Genetic Association Studies
MH  - *Genetic Predisposition to Disease
MH  - HLA-DR4 Antigen/*genetics/immunology
MH  - Humans
MH  - Odds Ratio
MH  - Uveomeningoencephalitic Syndrome/*genetics/immunology
PMC - PMC4225552
EDAT- 2014/11/11 06:00
MHDA- 2015/10/22 06:00
PMCR- 2014/11/10
CRDT- 2014/11/11 06:00
PHST- 2014/07/31 00:00 [received]
PHST- 2014/10/14 00:00 [accepted]
PHST- 2014/11/11 06:00 [entrez]
PHST- 2014/11/11 06:00 [pubmed]
PHST- 2015/10/22 06:00 [medline]
PHST- 2014/11/10 00:00 [pmc-release]
AID - srep06887 [pii]
AID - 10.1038/srep06887 [doi]
PST - epublish
SO  - Sci Rep. 2014 Nov 10;4:6887. doi: 10.1038/srep06887.