PMID- 25382103
OWN - NLM
STAT- MEDLINE
DCOM- 20150901
LR  - 20141124
IS  - 1744-8344 (Electronic)
IS  - 1477-9072 (Linking)
VI  - 12
IP  - 12
DP  - 2014 Dec
TI  - Baroreflex activation therapy: a new treatment option for heart failure with 
      reduced ejection fraction.
PG  - 1465-9
LID - 10.1586/14779072.2014.979790 [doi]
AB  - Sympathovagal imbalance plays a major role in the progression of heart failure 
      with reduced ejection fraction. Baroreflex activation therapy (BAT) by electrical 
      stimulation of baroreceptors located at the carotid sinus can reduce sympathetic 
      and increase parasympathetic tone. This review provides an overview on the 
      concept of BAT in heart failure with reduced ejection fraction and available 
      preclinical and clinical data. Animal studies of BAT in heart failure with 
      reduced ejection fraction have demonstrated a decline in plasma norepinephrine, 
      an improved left ventricular ejection fraction, a reduced susceptibility to 
      induced ventricular arrhythmias and a survival benefit. First clinical data from 
      uncontrolled studies suggest a relevant improvement in muscle sympathetic nerve 
      activity, ejection fraction, 6-min walk distance, New York Heart Association 
      (NYHA) class and hospitalization rate. BAT appears to be safe in this severely 
      ill patient population.
FAU - Halbach, Marcel
AU  - Halbach M
AD  - Department of Internal Medicine III, Heart Center, University of Cologne, 
      Kerpener Str. 62, 50937 Cologne, Germany.
FAU - Hickethier, Tilman
AU  - Hickethier T
FAU - Madershahian, Navid
AU  - Madershahian N
FAU - Muller-Ehmsen, Jochen
AU  - Muller-Ehmsen J
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20141110
PL  - England
TA  - Expert Rev Cardiovasc Ther
JT  - Expert review of cardiovascular therapy
JID - 101182328
SB  - IM
MH  - Animals
MH  - Baroreflex/*physiology
MH  - Blood Pressure/physiology
MH  - Carotid Sinus/physiopathology
MH  - Heart Failure/*therapy
MH  - Humans
MH  - Pressoreceptors/*physiopathology
MH  - Ventricular Function, Left/*physiology
OTO - NOTNLM
OT  - baroreceptor
OT  - baroreflex activation therapy
OT  - heart failure
OT  - interventional treatment
OT  - review
EDAT- 2014/11/11 06:00
MHDA- 2015/09/02 06:00
CRDT- 2014/11/11 06:00
PHST- 2014/11/11 06:00 [entrez]
PHST- 2014/11/11 06:00 [pubmed]
PHST- 2015/09/02 06:00 [medline]
AID - 10.1586/14779072.2014.979790 [doi]
PST - ppublish
SO  - Expert Rev Cardiovasc Ther. 2014 Dec;12(12):1465-9. doi: 
      10.1586/14779072.2014.979790. Epub 2014 Nov 10.