PMID- 25382329
OWN - NLM
STAT- MEDLINE
DCOM- 20170210
LR  - 20170210
IS  - 2542-5641 (Electronic)
IS  - 0366-6999 (Linking)
VI  - 127
IP  - 21
DP  - 2014
TI  - Investigation of drugs responsible for perioperative anaphylactic reactions using 
      cellular allergen stimulation test.
PG  - 3738-43
AB  - BACKGROUND: Anaphylactic reactions during anesthesia and operation are common and 
      life threatening. Follow-up investigation is necessary for avoiding potential 
      re-exposure of the patients to the offending drugs. The purpose of this study was 
      to assess cellular allergen stimulation test (CAST) as a diagnostic instrument in 
      immunoglobulin E (IgE)- and non-IgE-mediated anaphylactic reactions. METHODS: 
      This study included 25 patients who developed perioperative anaphylactic 
      reactions and 10 subjects that tolerated anesthetics and other drugs during 
      perioperative period from September 2009 to October 2013 in Peking Union Medical 
      College Hospital. We performed skin tests and flow cytometric analysis of 
      basophil activation-based CAST in all subjects. RESULTS: Of the 25 patients, 17 
      had IgE-mediated anaphylactic reactions (causative agent identified by skin 
      tests) and 8 had non-IgE-mediated anaphylactic reactions (negative skin tests). 
      CAST showed a sensitivity of 42.9%, specificity of 90%, and negative predictive 
      value of 80.6% for neuromuscular blocking agents. CONCLUSIONS: CAST may be useful 
      for the diagnosis of anaphylactic reactions during perioperative period. Our 
      findings call for further investigation to increase the sensitivity of the test.
FAU - Xin, Xin
AU  - Xin X
AD  - Department of Anesthesiology, Peking Union Medical College Hospital, Chinese 
      Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, 
      China.
FAU - Zou, Yi
AU  - Zou Y
AD  - Department of Anesthesiology, Peking Union Medical College Hospital, Chinese 
      Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, 
      China.
FAU - Xing, Lijiao
AU  - Xing L
AD  - Department of Anesthesiology, Peking Union Medical College Hospital, Chinese 
      Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, 
      China.
FAU - Yin, Jia
AU  - Yin J
AD  - Department of Allergy, Peking Union Medical College Hospital, Chinese Academy of 
      Medical Sciences & Peking Union Medical College, Beijing 100730, China.
FAU - Gu, Jianqing
AU  - Gu J
AD  - Department of Allergy, Peking Union Medical College Hospital, Chinese Academy of 
      Medical Sciences & Peking Union Medical College, Beijing 100730, China.
FAU - Wang, Zixi
AU  - Wang Z
AD  - Department of Allergy, Peking Union Medical College Hospital, Chinese Academy of 
      Medical Sciences & Peking Union Medical College, Beijing 100730, China.
FAU - Huang, Yuguang
AU  - Huang Y
AD  - Department of Anesthesiology, Peking Union Medical College Hospital, Chinese 
      Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, 
      China.
FAU - Zhao, Jing
AU  - Zhao J
AD  - Department of Anesthesiology, Peking Union Medical College Hospital, Chinese 
      Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, 
      China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Chin Med J (Engl)
JT  - Chinese medical journal
JID - 7513795
RN  - 0 (Allergens)
SB  - IM
MH  - Adult
MH  - Allergens/*immunology
MH  - Anaphylaxis/*diagnosis
MH  - Drug Hypersensitivity
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Perioperative Period
MH  - Skin Tests/*methods
MH  - Young Adult
EDAT- 2014/11/11 06:00
MHDA- 2017/02/12 06:00
CRDT- 2014/11/11 06:00
PHST- 2014/11/11 06:00 [entrez]
PHST- 2014/11/11 06:00 [pubmed]
PHST- 2017/02/12 06:00 [medline]
PST - ppublish
SO  - Chin Med J (Engl). 2014;127(21):3738-43.