PMID- 25382387
OWN - NLM
STAT- MEDLINE
DCOM- 20150914
LR  - 20191210
IS  - 1399-0012 (Electronic)
IS  - 0902-0063 (Linking)
VI  - 29
IP  - 1
DP  - 2015 Jan
TI  - Long-term impact of human leukocyte antigen mismatches combined with expanded 
      criteria donor on allograft outcomes in deceased donor kidney transplantation.
PG  - 44-51
LID - 10.1111/ctr.12487 [doi]
AB  - The long-term impact of human leukocyte antigen (HLA) mismatches combined with 
      expanded criteria donors (ECD) on clinical outcomes has not been fully evaluated 
      in recipients of deceased donor (DD) kidney transplantations. Of 595 DD renal 
      transplant recipients in our center between 1991 and 2011, 210 recipients (36%) 
      had 0-3 HLA mismatches/standard criteria donor (SCD), 353 (59%) had 4-6 HLA 
      mismatches/SCD or 0-3 HLA mismatches/ECD, and 32 (5%) had 4-6 HLA mismatches/ECD. 
      The mortality rate was significantly highest in the patients with 4-6 HLA 
      mismatches/ECD (p = 0.040). The most common cause of death in this group was 
      infection (50%). There were no significant differences in overall graft survival 
      and death-censored graft survival. The biopsy-proven acute rejection rate was 
      significantly higher in the 4-6 HLA mismatches/ECD group (p = 0.011). 
      Cox-regression multivariate analyses showed that 4-6 HLA mismatches plus ECD 
      (adjusted hazard ratio [AHR], 3.2; 95% confidence interval [CI], 1.17-10.56) and 
      diabetes (AHR, 4.3; 95% CI, 1.50-12.28) were significant predictors of recipient 
      mortality. In conclusion, >/=4 HLA mismatches plus ECD were associated with 
      significantly higher rates of biopsy-proven acute rejection and mortality 
      compared with other groups undergoing DD kidney transplantation.
CI  - (c) 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Shin, Sung
AU  - Shin S
AD  - Department of Surgery, Asan Medical Center, University of Ulsan College of 
      Medicine, Seoul, Korea.
FAU - Kim, Young Hoon
AU  - Kim YH
FAU - Choi, Byung Hyun
AU  - Choi BH
FAU - Choi, Ji Yoon
AU  - Choi JY
FAU - Jung, Joo Hee
AU  - Jung JH
FAU - Cho, Han Kyung
AU  - Cho HK
FAU - Han, Duck Jong
AU  - Han DJ
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
DEP - 20141204
PL  - Denmark
TA  - Clin Transplant
JT  - Clinical transplantation
JID - 8710240
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Allografts/*immunology
MH  - Female
MH  - Follow-Up Studies
MH  - Graft Rejection/*immunology/mortality
MH  - Graft Survival/*immunology
MH  - HLA Antigens/*immunology
MH  - *Histocompatibility
MH  - Humans
MH  - Kidney Transplantation/*mortality
MH  - Male
MH  - Middle Aged
MH  - Outcome Assessment, Health Care
MH  - Retrospective Studies
MH  - Survival Analysis
MH  - Transplantation, Homologous/mortality
MH  - Treatment Outcome
OTO - NOTNLM
OT  - deceased donor
OT  - expanded criteria donor
OT  - human leukocyte antigen
OT  - kidney transplantation
EDAT- 2014/11/11 06:00
MHDA- 2015/09/15 06:00
CRDT- 2014/11/11 06:00
PHST- 2014/10/22 00:00 [accepted]
PHST- 2014/11/11 06:00 [entrez]
PHST- 2014/11/11 06:00 [pubmed]
PHST- 2015/09/15 06:00 [medline]
AID - 10.1111/ctr.12487 [doi]
PST - ppublish
SO  - Clin Transplant. 2015 Jan;29(1):44-51. doi: 10.1111/ctr.12487. Epub 2014 Dec 4.