PMID- 25382665
OWN - NLM
STAT- MEDLINE
DCOM- 20150413
LR  - 20181113
IS  - 1096-8652 (Electronic)
IS  - 0361-8609 (Print)
IS  - 0361-8609 (Linking)
VI  - 90
IP  - 3
DP  - 2015 Mar
TI  - Clinical outcomes of splenectomy in children: report of the splenectomy in 
      congenital hemolytic anemia registry.
PG  - 187-92
LID - 10.1002/ajh.23888 [doi]
AB  - The outcomes of children with congenital hemolytic anemia (CHA) undergoing total 
      splenectomy (TS) or partial splenectomy (PS) remain unclear. In this study, we 
      collected data from 100 children with CHA who underwent TS or PS from 2005 to 
      2013 at 16 sites in the Splenectomy in Congenital Hemolytic Anemia (SICHA) 
      consortium using a patient registry. We analyzed demographics and baseline 
      clinical status, operative details, and outcomes at 4, 24, and 52 weeks after 
      surgery. Results were summarized as hematologic outcomes, short-term adverse 
      events (AEs) (</=30 days after surgery), and long-term AEs (31-365 days after 
      surgery). For children with hereditary spherocytosis, after surgery there was an 
      increase in hemoglobin (baseline 10.1 +/- 1.8 g/dl, 52 week 12.8 +/- 1.6 g/dl; 
      mean +/- SD), decrease in reticulocyte and bilirubin as well as control of 
      symptoms. Children with sickle cell disease had control of clinical symptoms 
      after surgery, but had no change in hematologic parameters. There was an 11% rate 
      of short-term AEs and 11% rate of long-term AEs. As we accumulate more subjects 
      and longer follow-up, use of a patient registry should enhance our capacity for 
      clinical trials and engage all stakeholders in the decision-making process.
CI  - (c) 2014 Wiley Periodicals, Inc.
FAU - Rice, Henry E
AU  - Rice HE
AD  - Duke University Medical Center, Durham, North Carolina.
FAU - Englum, Brian R
AU  - Englum BR
FAU - Rothman, Jennifer
AU  - Rothman J
FAU - Leonard, Sarah
AU  - Leonard S
FAU - Reiter, Audra
AU  - Reiter A
FAU - Thornburg, Courtney
AU  - Thornburg C
FAU - Brindle, Mary
AU  - Brindle M
FAU - Wright, Nicola
AU  - Wright N
FAU - Heeney, Matthew M
AU  - Heeney MM
FAU - Smithers, Charles
AU  - Smithers C
FAU - Brown, Rebeccah L
AU  - Brown RL
FAU - Kalfa, Theodosia
AU  - Kalfa T
FAU - Langer, Jacob C
AU  - Langer JC
FAU - Cada, Michaela
AU  - Cada M
FAU - Oldham, Keith T
AU  - Oldham KT
FAU - Scott, J Paul
AU  - Scott JP
FAU - St Peter, Shawn
AU  - St Peter S
FAU - Sharma, Mukta
AU  - Sharma M
FAU - Davidoff, Andrew M
AU  - Davidoff AM
FAU - Nottage, Kerri
AU  - Nottage K
FAU - Bernabe, Kathryn
AU  - Bernabe K
FAU - Wilson, David B
AU  - Wilson DB
FAU - Dutta, Sanjeev
AU  - Dutta S
FAU - Glader, Bertil
AU  - Glader B
FAU - Crary, Shelley E
AU  - Crary SE
FAU - Dassinger, Melvin S
AU  - Dassinger MS
FAU - Dunbar, Levette
AU  - Dunbar L
FAU - Islam, Saleem
AU  - Islam S
FAU - Kumar, Manjusha
AU  - Kumar M
FAU - Rescorla, Fred
AU  - Rescorla F
FAU - Bruch, Steve
AU  - Bruch S
FAU - Campbell, Andrew
AU  - Campbell A
FAU - Austin, Mary
AU  - Austin M
FAU - Sidonio, Robert
AU  - Sidonio R
FAU - Blakely, Martin L
AU  - Blakely ML
CN  - Splenectomy in Congenital Hemolytic Anemia (SICHA) Consortium
LA  - eng
GR  - KL2 TR000446/TR/NCATS NIH HHS/United States
GR  - UL1 TR001117/TR/NCATS NIH HHS/United States
GR  - UM1 HL088953/HL/NHLBI NIH HHS/United States
GR  - UL1TR001117/TR/NCATS NIH HHS/United States
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, N.I.H., Extramural
DEP - 20141124
PL  - United States
TA  - Am J Hematol
JT  - American journal of hematology
JID - 7610369
RN  - 0 (Ankyrins)
RN  - 0 (Hemoglobins)
RN  - RFM9X3LJ49 (Bilirubin)
RN  - Spherocytosis, Type 1
SB  - IM
MH  - Acute Chest Syndrome/etiology/*pathology
MH  - Adolescent
MH  - Anemia, Hemolytic, Congenital/pathology/*surgery
MH  - Anemia, Sickle Cell/pathology/*surgery
MH  - Ankyrins/*deficiency
MH  - Bilirubin/blood
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Hemoglobins/metabolism
MH  - Humans
MH  - Male
MH  - Postoperative Complications/*pathology
MH  - Registries
MH  - Respiratory Tract Infections/etiology/*pathology
MH  - Reticulocytes/pathology
MH  - Spherocytosis, Hereditary/pathology/*surgery
MH  - Splenectomy/*methods
MH  - Treatment Outcome
MH  - United States
PMC - PMC4333061
MID - NIHMS640806
COIS- Conflict-of-interest disclosure: All authors have no financial relationships or 
      conflicts of interest relative to this article to disclose.
FIR - Herzberg, Brittany
IR  - Herzberg B
FIR - Ferranti, Jeffrey M
IR  - Ferranti JM
FIR - Mouttalib, Sofia
IR  - Mouttalib S
FIR - Nahm, Meredith
IR  - Nahm M
FIR - Richesson, Rachel
IR  - Richesson R
FIR - Snyder, Denise C
IR  - Snyder DC
EDAT- 2014/11/11 06:00
MHDA- 2015/04/14 06:00
PMCR- 2016/03/01
CRDT- 2014/11/11 06:00
PHST- 2014/10/28 00:00 [received]
PHST- 2014/10/29 00:00 [accepted]
PHST- 2014/11/11 06:00 [entrez]
PHST- 2014/11/11 06:00 [pubmed]
PHST- 2015/04/14 06:00 [medline]
PHST- 2016/03/01 00:00 [pmc-release]
AID - 10.1002/ajh.23888 [doi]
PST - ppublish
SO  - Am J Hematol. 2015 Mar;90(3):187-92. doi: 10.1002/ajh.23888. Epub 2014 Nov 24.