PMID- 25382744
OWN - NLM
STAT- MEDLINE
DCOM- 20150615
LR  - 20150414
IS  - 1469-8749 (Electronic)
IS  - 0012-1622 (Linking)
VI  - 57
IP  - 5
DP  - 2015 May
TI  - Cerebral oxygenation is associated with neurodevelopmental outcome of preterm 
      children at age 2 to 3 years.
PG  - 449-55
LID - 10.1111/dmcn.12622 [doi]
AB  - AIM: The aim of the study was to determine whether regional cerebral tissue 
      oxygen saturation (r(c)SO2) and fractional tissue oxygen extraction (FTOE), using 
      near-infrared spectroscopy, are associated with neurodevelopmental outcome of 
      preterm infants. METHOD: We measured rc SO2 on days 1, 2, 3, 4, 5, 8, and 15 
      after birth in 83 preterm infants (<32wks gestational age), and calculated 
      FTOE=(SpO2 -r(c)SO2)/SpO2. Cognitive, motor, neurological, and behavioural 
      outcomes were determined at 2 to 3 years using the Bayley Scales of Infant and 
      Toddler Development, Third Edition (BSID-III), an age-specific neurological 
      examination, and the Child Behavior Checklist (CBCL) respectively. Multiple 
      linear regression analyses were used to determine whether r(c)SO2 and FTOE 
      contributed to outcome. RESULTS: We followed up 67 infants. The lower quartile 
      (P(25-50)) and highest quartile (P(75-100)) of r(c)SO2 on day 1 were associated 
      with poorer cognitive outcome (p=0.044 and p=0.008 respectively). A lower area 
      under the curve (AUC; over 15d) of r(c)SO2 was associated with poorer cognitive 
      outcome (p=0.014). The lower quartile (P(25-50)) AUC of r(c)SO2 was associated 
      with poorer fine motor outcome (p=0.004). The amount of time r(c)SO2 <50% on day 
      1 was negatively associated with gross motor outcome (p=0.002). The highest 
      quartile of FTOE on day 1 was associated with poorer total motor outcome 
      (p=0.041). INTERPRETATION: Cerebral oxygen saturation during the first 2 weeks 
      after birth is associated with neurodevelopmental outcome of preterm infants at 2 
      to 3 years. High and low r(c)SO2 on day 1 were associated with poorer 
      neurodevelopmental outcome.
CI  - (c) 2014 Mac Keith Press.
FAU - Verhagen, Elise A
AU  - Verhagen EA
AD  - Division of Neonatology, Beatrix Children's Hospital, University Medical Center 
      Groningen, University of Groningen, Groningen, the Netherlands.
FAU - Van Braeckel, Koenraad N J A
AU  - Van Braeckel KN
FAU - van der Veere, Christa N
AU  - van der Veere CN
FAU - Groen, Henk
AU  - Groen H
FAU - Dijk, Peter H
AU  - Dijk PH
FAU - Hulzebos, Christian V
AU  - Hulzebos CV
FAU - Bos, Arend F
AU  - Bos AF
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20141108
PL  - England
TA  - Dev Med Child Neurol
JT  - Developmental medicine and child neurology
JID - 0006761
RN  - S88TT14065 (Oxygen)
SB  - IM
CIN - Dev Med Child Neurol. 2015 May;57(5):404-5. PMID: 25521709
MH  - Brain/*metabolism
MH  - Child Development/*physiology
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - Infant, Newborn
MH  - Infant, Premature/*metabolism
MH  - Longitudinal Studies
MH  - Male
MH  - Oxygen/*metabolism
MH  - Oxygen Consumption/physiology
MH  - Spectroscopy, Near-Infrared/*methods
EDAT- 2014/11/11 06:00
MHDA- 2015/06/16 06:00
CRDT- 2014/11/11 06:00
PHST- 2014/09/04 00:00 [accepted]
PHST- 2014/11/11 06:00 [entrez]
PHST- 2014/11/11 06:00 [pubmed]
PHST- 2015/06/16 06:00 [medline]
AID - 10.1111/dmcn.12622 [doi]
PST - ppublish
SO  - Dev Med Child Neurol. 2015 May;57(5):449-55. doi: 10.1111/dmcn.12622. Epub 2014 
      Nov 8.