PMID- 25383981
OWN - NLM
STAT- MEDLINE
DCOM- 20151203
LR  - 20221207
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 9
IP  - 11
DP  - 2014
TI  - Association of brain-derived neurotrophic factor gene Val66Met polymorphism with 
      primary dysmenorrhea.
PG  - e112766
LID - 10.1371/journal.pone.0112766 [doi]
LID - e112766
AB  - Primary dysmenorrhea (PDM), the most prevalent menstrual cycle-related problem in 
      women of reproductive age, is associated with negative moods. Whether the 
      menstrual pain and negative moods have a genetic basis remains unknown. 
      Brain-derived neurotrophic factor (BDNF) plays a key role in the production of 
      central sensitization and contributes to chronic pain conditions. BDNF has also 
      been implicated in stress-related mood disorders. We screened and genotyped the 
      BDNF Val66Met polymorphism (rs6265) in 99 Taiwanese (Asian) PDMs (20-30 years 
      old) and 101 age-matched healthy female controls. We found that there was a 
      significantly higher frequency of the Met allele of the BDNF Val66Met 
      polymorphism in the PDM group. Furthermore, BDNF Met/Met homozygosity had a 
      significantly stronger association with PDM compared with Val carrier status. 
      Subsequent behavioral/hormonal assessments of sub-groups (PDMs = 78, controls = 
      81; eligible for longitudinal multimodal neuroimaging battery studies) revealed 
      that the BDNF Met/Met homozygous PDMs exhibited a higher menstrual pain score 
      (sensory dimension) and a more anxious mood than the Val carrier PDMs during the 
      menstrual phase. Although preliminary, our study suggests that the BDNF Val66Met 
      polymorphism is associated with PDM in Taiwanese (Asian) people, and BDNF Met/Met 
      homozygosity may be associated with an increased risk of PDM. Our data also 
      suggest the BDNF Val66Met polymorphism as a possible regulator of menstrual pain 
      and pain-related emotions in PDM. Absence of thermal hypersensitivity may connote 
      an ethnic attribution. The presentation of our findings calls for further genetic 
      and neuroscientific investigations of PDM.
FAU - Lee, Lin-Chien
AU  - Lee LC
AD  - Institute of Brain Science, National Yang-Ming University, Taipei, Taiwan; 
      Department of Physical Medicine and Rehabilitation, Cheng Hsin General Hospital, 
      Taipei, Taiwan; Integrated Brain Research Unit, Division of Clinical Research, 
      Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan.
FAU - Tu, Cheng-Hao
AU  - Tu CH
AD  - Institute of Brain Science, National Yang-Ming University, Taipei, Taiwan; 
      Integrated Brain Research Unit, Division of Clinical Research, Department of 
      Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan; Department of 
      Education and Research, Taipei City Hospital, Taipei, Taiwan.
FAU - Chen, Li-Fen
AU  - Chen LF
AD  - Institute of Brain Science, National Yang-Ming University, Taipei, Taiwan; 
      Integrated Brain Research Unit, Division of Clinical Research, Department of 
      Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan.
FAU - Shen, Horng-Der
AU  - Shen HD
AD  - Division of Basic Research, Department of Medical Research, Taipei Veterans 
      General Hospital, Taipei, Taiwan.
FAU - Chao, Hsiang-Tai
AU  - Chao HT
AD  - Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, 
      Taipei, Taiwan; Department of Obstetrics and Gynecology, Faculty of Medicine, 
      School of Medicine, National Yang-Ming University, Taipei, Taiwan.
FAU - Lin, Ming-Wei
AU  - Lin MW
AD  - Division of Basic Research, Department of Medical Research, Taipei Veterans 
      General Hospital, Taipei, Taiwan; Institute of Public Health, National Yang-Ming 
      University, Taipei, Taiwan.
FAU - Hsieh, Jen-Chuen
AU  - Hsieh JC
AD  - Institute of Brain Science, National Yang-Ming University, Taipei, Taiwan; 
      Integrated Brain Research Unit, Division of Clinical Research, Department of 
      Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141110
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
RN  - AE28F7PNPL (Methionine)
RN  - HG18B9YRS7 (Valine)
SB  - IM
MH  - Adult
MH  - Asian People/*genetics
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Case-Control Studies
MH  - Dysmenorrhea/*genetics/psychology
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Methionine/*genetics
MH  - *Polymorphism, Single Nucleotide
MH  - Taiwan
MH  - Valine/*genetics
MH  - Young Adult
PMC - PMC4226574
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2014/11/11 06:00
MHDA- 2015/12/15 06:00
PMCR- 2014/11/10
CRDT- 2014/11/11 06:00
PHST- 2014/02/11 00:00 [received]
PHST- 2014/10/15 00:00 [accepted]
PHST- 2014/11/11 06:00 [entrez]
PHST- 2014/11/11 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
PHST- 2014/11/10 00:00 [pmc-release]
AID - PONE-D-14-06377 [pii]
AID - 10.1371/journal.pone.0112766 [doi]
PST - epublish
SO  - PLoS One. 2014 Nov 10;9(11):e112766. doi: 10.1371/journal.pone.0112766. 
      eCollection 2014.