PMID- 25384632
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20141113
LR  - 20220409
IS  - 0924-2708 (Print)
IS  - 0924-2708 (Linking)
VI  - 21
IP  - 4
DP  - 2009 Aug
TI  - Lack of association between BDNF Val66Met gene polymorphism and late-onset 
      depression in a Chinese Han population.
PG  - 186-90
LID - 10.1111/j.1601-5215.2009.00401.x [doi]
AB  - BACKGROUND: Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) 
      gene has been suggested to be associated with major depressive disorder (MDD). 
      There were a few reports of the relationship between the variant and late-onset 
      depression (LOD) in Chinese Han population. OBJECTIVE: To investigate the 
      relationship among BDNF Val66Met gene variants, BDNF plasma level and LOD. 
      METHODS: Chinese Han patients with LOD (n = 99) and control subjects (n = 110) 
      were assessed for BDNF Val66Met gene polymorphism. BDNF plasma level was tested 
      only in LOD. RESULTS: There were no significant differences in genotypes and 
      allele frequencies between cases and controls (p = 0.744 and p = 0.845, 
      respectively). Plasma BDNF level also did not show significant differences in 
      three genotypes in LOD (p = 0.860). CONCLUSION: The Val66Met polymorphism in BDNF 
      gene may not confer susceptibility to LOD in Chinese Han population.
FAU - You, Jiayong
AU  - You J
AD  - 1Department of Psychiatry, Nanjing Brain Hospital affiliated to Nanjing Medical 
      University, Nanjing, 210029, China.
FAU - Yuan, Yonggui
AU  - Yuan Y
AD  - 1Department of Psychiatry, Nanjing Brain Hospital affiliated to Nanjing Medical 
      University, Nanjing, 210029, China.
FAU - Shi, Yanyan
AU  - Shi Y
AD  - 1Department of Psychiatry, Nanjing Brain Hospital affiliated to Nanjing Medical 
      University, Nanjing, 210029, China.
FAU - Zhang, Zhijun
AU  - Zhang Z
AD  - 2Department of Neuropsychiatry, Affiliated ZhongDa Hospital of Southeast 
      University, Nanjing, 210009, China.
FAU - Zhang, Xiangrong
AU  - Zhang X
AD  - 1Department of Psychiatry, Nanjing Brain Hospital affiliated to Nanjing Medical 
      University, Nanjing, 210029, China.
FAU - Li, Hailin
AU  - Li H
AD  - 1Department of Psychiatry, Nanjing Brain Hospital affiliated to Nanjing Medical 
      University, Nanjing, 210029, China.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Acta Neuropsychiatr
JT  - Acta neuropsychiatrica
JID - 9612501
EDAT- 2009/08/01 00:00
MHDA- 2009/08/01 00:01
CRDT- 2014/11/12 06:00
PHST- 2014/11/12 06:00 [entrez]
PHST- 2009/08/01 00:00 [pubmed]
PHST- 2009/08/01 00:01 [medline]
AID - S0924270800001216 [pii]
AID - 10.1111/j.1601-5215.2009.00401.x [doi]
PST - ppublish
SO  - Acta Neuropsychiatr. 2009 Aug;21(4):186-90. doi: 
      10.1111/j.1601-5215.2009.00401.x.