PMID- 25385024
OWN - NLM
STAT- MEDLINE
DCOM- 20160229
LR  - 20240322
IS  - 1573-3521 (Electronic)
IS  - 0160-7715 (Print)
IS  - 0160-7715 (Linking)
VI  - 38
IP  - 2
DP  - 2015 Apr
TI  - Neurophysiological evidence for remediation of reward processing deficits in 
      chronic pain and opioid misuse following treatment with Mindfulness-Oriented 
      Recovery Enhancement: exploratory ERP findings from a pilot RCT.
PG  - 327-36
LID - 10.1007/s10865-014-9607-0 [doi]
AB  - Dysregulated processing of natural rewards may be a central pathogenic process in 
      the etiology and maintenance of prescription opioid misuse and addiction among 
      chronic pain patients. This study examined whether a Mindfulness-Oriented 
      Recovery Enhancement (MORE) intervention could augment natural reward processing 
      through training in savoring as indicated by event-related brain potentials 
      (ERPs). Participants were chronic pain patients at risk for opioid misuse who 
      were randomized to 8 weeks of MORE (n = 11) or a support group control condition 
      (n = 18). ERPs to images representing naturally rewarding stimuli (e.g., 
      beautiful landscapes, intimate couples) and neutral images were measured before 
      and after 8 weeks of treatment. Analyses focused on the late positive potential 
      (LPP)--an ERP response in the 400-1,000 ms time window thought to index 
      allocation of attention to emotional information. Treatment with MORE was 
      associated with significant increases in LPP response to natural reward stimuli 
      relative to neutral stimuli which were correlated with enhanced positive 
      affective cue-responses and reductions in opioid craving from pre- to 
      post-treatment. Findings suggest that cognitive training regimens centered on 
      strengthening attention to natural rewards may remediate reward processing 
      deficits underpinning addictive behavior.
FAU - Garland, Eric L
AU  - Garland EL
AD  - University of Utah, 395 South, 1500 East, Salt Lake City, UT, 84112, USA, 
      eric.garland@socwk.utah.edu.
FAU - Froeliger, Brett
AU  - Froeliger B
FAU - Howard, Matthew O
AU  - Howard MO
LA  - eng
GR  - R34 DA037005/DA/NIDA NIH HHS/United States
GR  - DA032517/DA/NIDA NIH HHS/United States
GR  - DA037005/DA/NIDA NIH HHS/United States
GR  - R03 DA032517/DA/NIDA NIH HHS/United States
GR  - R01 DA042033/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20141111
PL  - United States
TA  - J Behav Med
JT  - Journal of behavioral medicine
JID - 7807105
RN  - 0 (Analgesics, Opioid)
SB  - IM
MH  - Analgesics, Opioid/adverse effects
MH  - Chronic Pain/complications/*physiopathology/therapy
MH  - Evoked Potentials, Visual/*physiology
MH  - Female
MH  - Humans
MH  - Individuality
MH  - Male
MH  - Middle Aged
MH  - *Mindfulness
MH  - Opioid-Related Disorders/complications/*physiopathology/therapy
MH  - Pilot Projects
MH  - *Reward
PMC - PMC4355224
MID - NIHMS641689
COIS- Conflicts of Interest: ELG, BF, & MOH declare that they have no conflict of 
      interest.
EDAT- 2014/11/12 06:00
MHDA- 2016/03/02 06:00
PMCR- 2016/04/01
CRDT- 2014/11/12 06:00
PHST- 2014/06/03 00:00 [received]
PHST- 2014/10/30 00:00 [accepted]
PHST- 2014/11/12 06:00 [entrez]
PHST- 2014/11/12 06:00 [pubmed]
PHST- 2016/03/02 06:00 [medline]
PHST- 2016/04/01 00:00 [pmc-release]
AID - 10.1007/s10865-014-9607-0 [doi]
PST - ppublish
SO  - J Behav Med. 2015 Apr;38(2):327-36. doi: 10.1007/s10865-014-9607-0. Epub 2014 Nov 
      11.