PMID- 25385044
OWN - NLM
STAT- MEDLINE
DCOM- 20150821
LR  - 20141222
IS  - 1791-2423 (Electronic)
IS  - 1019-6439 (Linking)
VI  - 46
IP  - 2
DP  - 2015 Feb
TI  - Oligomer procyanidins (F2) isolated from grape seeds inhibits tumor angiogenesis 
      and cell invasion by targeting HIF-1alpha in vitro.
PG  - 708-20
LID - 10.3892/ijo.2014.2744 [doi]
AB  - Overexpression of hypoxia-inducible factor-1 (HIF-1) alpha, a transcription factor 
      which immortalizes tumors by inducing expression of the genes involved in cell 
      survival, migration and angiogenesis, is closely associated with poor prognosis, 
      increased risk of metastasis and increased mortality. Oligomer procyanidins (F2), 
      a natural fraction from grape seeds, has been demonstrated to have antioxidant 
      and antitumor activities, however the antitumor effect of F2 targeting HIF-1alpha 
      remains unknown. The present study showed that F2 markedly decreased HIF-1alpha and 
      the expression of its target genes in cancer cells through inactivating the 
      EGFR-PI3K-AKT-mTOR and MAPK-ERK1/2 pathways. Moreover, F2 suppressed vascular 
      endothelial growth factor (VEGF) and matrix metalloproteinases (MMP)-2 
      expressions, followed by the inhibition of tumor angiogenesis and cell invasion 
      in a HIF-1alpha-dependent manner. Collectively, these findings indicate that the 
      antitumor effect of F2 is, at least in part, mediated by suppressing 
      HIF-1alpha-dependent pathway, and suggest that F2 may be a potentially useful agent 
      for treatment of human cancer.
FAU - Zheng, Hong Li
AU  - Zheng HL
AD  - Department of Pharmacology, Shenyang Pharmaceutical University, Shenhe District, 
      110016 Shenyang, P.R. China.
FAU - Yang, Jingyu
AU  - Yang J
AD  - Department of Pharmacology, Shenyang Pharmaceutical University, Shenhe District, 
      110016 Shenyang, P.R. China.
FAU - Hou, Yue
AU  - Hou Y
AD  - Department of Pharmacology, Shenyang Pharmaceutical University, Shenhe District, 
      110016 Shenyang, P.R. China.
FAU - Sun, Baoshan
AU  - Sun B
AD  - Department of Drug Analysis, Shenyang Pharmaceutical University, Shenhe District, 
      110016 Shenyang, P.R. China.
FAU - Zhang, Qingchun
AU  - Zhang Q
AD  - Department of Pharmacology, Shenyang Pharmaceutical University, Shenhe District, 
      110016 Shenyang, P.R. China.
FAU - Mou, Yanhua
AU  - Mou Y
AD  - Department of Pharmacology, Shenyang Pharmaceutical University, Shenhe District, 
      110016 Shenyang, P.R. China.
FAU - Wand, Lihui
AU  - Wand L
AD  - Department of Pharmacology, Shenyang Pharmaceutical University, Shenhe District, 
      110016 Shenyang, P.R. China.
FAU - Wu, Chunfu
AU  - Wu C
AD  - Department of Pharmacology, Shenyang Pharmaceutical University, Shenhe District, 
      110016 Shenyang, P.R. China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141110
PL  - Greece
TA  - Int J Oncol
JT  - International journal of oncology
JID - 9306042
RN  - 0 (Antineoplastic Agents, Phytogenic)
RN  - 0 (Grape Seed Extract)
RN  - 0 (HIF1A protein, human)
RN  - 0 (Hypoxia-Inducible Factor 1, alpha Subunit)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Proanthocyanidins)
SB  - IM
MH  - Antineoplastic Agents, Phytogenic/*administration & dosage
MH  - Astrocytoma/*drug therapy/genetics/pathology
MH  - Cell Hypoxia/drug effects
MH  - Cell Line, Tumor
MH  - Gene Expression Regulation, Neoplastic/drug effects
MH  - Grape Seed Extract/administration & dosage
MH  - Humans
MH  - Hypoxia-Inducible Factor 1, alpha Subunit/*biosynthesis/genetics
MH  - Neoplasm Invasiveness/genetics/pathology
MH  - Neoplasm Proteins/biosynthesis/drug effects
MH  - Neovascularization, Pathologic/*drug therapy/genetics/pathology
MH  - Proanthocyanidins/*administration & dosage
MH  - Signal Transduction/drug effects
EDAT- 2014/11/12 06:00
MHDA- 2015/08/22 06:00
CRDT- 2014/11/12 06:00
PHST- 2014/08/06 00:00 [received]
PHST- 2014/09/11 00:00 [accepted]
PHST- 2014/11/12 06:00 [entrez]
PHST- 2014/11/12 06:00 [pubmed]
PHST- 2015/08/22 06:00 [medline]
AID - 10.3892/ijo.2014.2744 [doi]
PST - ppublish
SO  - Int J Oncol. 2015 Feb;46(2):708-20. doi: 10.3892/ijo.2014.2744. Epub 2014 Nov 10.