PMID- 25385146
OWN - NLM
STAT- MEDLINE
DCOM- 20151015
LR  - 20141208
IS  - 1791-3004 (Electronic)
IS  - 1791-2997 (Linking)
VI  - 11
IP  - 3
DP  - 2015 Mar
TI  - Suppression of dendritic cell and T-cell activation by the pRST(9)(8) Salmonella 
      plasmid.
PG  - 2306-14
LID - 10.3892/mmr.2014.2919 [doi]
AB  - Salmonella evades host immune response via the expression of a variety of 
      pathogenic factors. The 'pRST98' plasmid of Salmonella enterica serotype Typhi 
      (S. Typhi) is involved in conferring the multidrug‑resistance and virulence of S. 
      typhi. However, its specific effect on host‑cell function has remained elusive. 
      Dendritic cells (DCs) are key regulators of immune responses. The present study 
      therefore aimed to investigate whether pRST98 may target DCs involved in 
      mediating the adaptive immune response. In vivo experiments with Salmonella 
      enterica serotype Typhimurium chi3337 and chi3337/pRST98 revealed that pRST98 may 
      influence multiple important functions of murine DCs, including maturation, 
      survival and cytokine production. In addition, pRST98 markedly contributed to 
      decreasing T‑cell activation. These data suggested that by targeting the 
      aforementioned functions of DCs, pRST98 may partially overturn the adaptive 
      immune defense mechanisms of the host, which are required for elimination of this 
      pathogen from infected tissues. This may contribute to the evasion of host 
      adaptive immune responses by S. Typhi and therefore provide a target for the 
      prevention and treatment of typhoid fever.
FAU - Wei, Li
AU  - Wei L
AD  - Department of Microbiology, Medical College of Soochow University, Suzhou, 
      Jiangsu 215123, P.R. China.
FAU - Jin, Qili
AU  - Jin Q
AD  - Department of Clinical Laboratory, The Second Affiliated Hospital of Bengbu 
      Medical College, Bengbu, Anhui 233040, P.R. China.
FAU - Chu, Yuanyuan
AU  - Chu Y
AD  - Department of Microbiology, Medical College of Soochow University, Suzhou, 
      Jiangsu 215123, P.R. China.
FAU - Wu, Shuyan
AU  - Wu S
AD  - Department of Microbiology, Medical College of Soochow University, Suzhou, 
      Jiangsu 215123, P.R. China.
FAU - Huang, Rui
AU  - Huang R
AD  - Department of Microbiology, Medical College of Soochow University, Suzhou, 
      Jiangsu 215123, P.R. China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141110
PL  - Greece
TA  - Mol Med Rep
JT  - Molecular medicine reports
JID - 101475259
SB  - IM
MH  - Animals
MH  - Bacterial Load
MH  - Cell Survival
MH  - Conjugation, Genetic
MH  - Dendritic Cells/*immunology/metabolism/*microbiology
MH  - Lymphocyte Activation/*immunology
MH  - Mice
MH  - Plasmids/*genetics
MH  - Salmonella/*genetics/pathogenicity
MH  - Salmonella Infections/immunology/microbiology
MH  - Salmonella typhi/genetics
MH  - T-Lymphocytes/*immunology/metabolism/*microbiology
EDAT- 2014/11/12 06:00
MHDA- 2015/10/16 06:00
CRDT- 2014/11/12 06:00
PHST- 2014/02/12 00:00 [received]
PHST- 2014/10/24 00:00 [accepted]
PHST- 2014/11/12 06:00 [entrez]
PHST- 2014/11/12 06:00 [pubmed]
PHST- 2015/10/16 06:00 [medline]
AID - 10.3892/mmr.2014.2919 [doi]
PST - ppublish
SO  - Mol Med Rep. 2015 Mar;11(3):2306-14. doi: 10.3892/mmr.2014.2919. Epub 2014 Nov 
      10.