PMID- 25386935
OWN - NLM
STAT- MEDLINE
DCOM- 20150914
LR  - 20181113
IS  - 1545-326X (Electronic)
IS  - 0066-4219 (Print)
IS  - 0066-4219 (Linking)
VI  - 66
DP  - 2015
TI  - T cell-mediated hypersensitivity reactions to drugs.
PG  - 439-54
LID - 10.1146/annurev-med-050913-022745 [doi]
AB  - The immunological mechanisms driving delayed hypersensitivity reactions (HSRs) to 
      drugs mediated by drug-reactive T lymphocytes are exemplified by several key 
      examples and their human leukocyte antigen (HLA) associations: abacavir and 
      HLA-B*57:01, carbamazepine and HLA-B*15:02, allo-purinol and HLA-B*58:01, and 
      both amoxicillin-clavulanate and nevirapine with multiple class I and II alleles. 
      For HLA-restricted drug HSRs, specific class I and/or II HLA alleles are 
      necessary but not sufficient for tissue specificity and the clinical syndrome. 
      Several models have been proposed to explain the immunopathogenesis of severe T 
      cell-mediated drug HSRs, and our increased understanding of the risk factors and 
      mechanisms involved in the development of these reactions will further the 
      development of sensitive and specific strategies for preclinical screening that 
      will lead to safer and more cost-effective drug design.
FAU - Pavlos, Rebecca
AU  - Pavlos R
AD  - Institute for Immunology and Infectious Diseases, Murdoch University, Murdoch, 
      Western Australia, 6150; email: e.phillips@iiid.com.au.
FAU - Mallal, Simon
AU  - Mallal S
FAU - Ostrov, David
AU  - Ostrov D
FAU - Buus, Soren
AU  - Buus S
FAU - Metushi, Imir
AU  - Metushi I
FAU - Peters, Bjoern
AU  - Peters B
FAU - Phillips, Elizabeth
AU  - Phillips E
LA  - eng
GR  - P50 GM115305/GM/NIGMS NIH HHS/United States
GR  - R01 AI103348/AI/NIAID NIH HHS/United States
GR  - U19 HL065962/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20141027
PL  - United States
TA  - Annu Rev Med
JT  - Annual review of medicine
JID - 2985151R
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Drug Hypersensitivity/genetics/*immunology
MH  - Drug Hypersensitivity Syndrome/genetics/immunology
MH  - HLA Antigens/genetics
MH  - Humans
MH  - Hypersensitivity, Delayed/genetics/*immunology
MH  - Stevens-Johnson Syndrome/genetics/immunology
MH  - T-Lymphocytes/*immunology
PMC - PMC4295772
MID - NIHMS651258
OTO - NOTNLM
OT  - Stevens-Johnson syndrome
OT  - altered peptide
OT  - human leukocyte antigen
OT  - major histocompatibility complex
OT  - pharmacogenomics
OT  - toxic epidermal necrolysis
EDAT- 2014/11/12 06:00
MHDA- 2015/09/15 06:00
PMCR- 2015/01/15
CRDT- 2014/11/12 06:00
PHST- 2014/11/12 06:00 [entrez]
PHST- 2014/11/12 06:00 [pubmed]
PHST- 2015/09/15 06:00 [medline]
PHST- 2015/01/15 00:00 [pmc-release]
AID - 10.1146/annurev-med-050913-022745 [doi]
PST - ppublish
SO  - Annu Rev Med. 2015;66:439-54. doi: 10.1146/annurev-med-050913-022745. Epub 2014 
      Oct 27.