PMID- 2538699
OWN - NLM
STAT- MEDLINE
DCOM- 19890502
LR  - 20190701
IS  - 0024-3205 (Print)
IS  - 0024-3205 (Linking)
VI  - 44
IP  - 7
DP  - 1989
TI  - Prenatal diazepam induced persisting depression of cellular immune responses.
PG  - 493-501
AB  - Treatment of pregnant Long Evans rats with a low dose of diazepam (1.25 mg/kg per 
      day s.c.) from gestational day (GD) 14 to 20 resulted in severe and long lasting 
      depression of cellular immune responses in male and female offspring. T 
      lymphocyte proliferation, induced by allogeneic stimulation in mixed lymphocyte 
      culture (MLC) or geneic stimulation in mixed lymphocyte culture (MLC) or 
      mitogenic stimulation (concanavalin A), decreased by 50 % or more over a 
      postnatal period of about 2 months. Treatment of the pregnant dam during the 
      early fetal period, from GD 12 to GD 16, did not significantly affect these 
      immune parameters, whereas treatment during later gestation, from GD 16 to 20, 
      significantly affected T lymphocyte function. Clonazepam, a benzodiazepine with 
      high affinity for the central type benzodiazepine site, also affected cellular 
      immune response in offspring. Our data indicate that benzodiazepine treatment 
      during the fetal period may result in persistent postnatal deficiency of cellular 
      immune responses. The relative role of central and peripheral type benzodiazepine 
      receptor and possible interactions with maternal and fetal pituitary - 
      adrenocortical systems are discussed.
FAU - Schlumpf, M
AU  - Schlumpf M
AD  - Institute of Pharmacology, University of Zurich, Switzerland.
FAU - Ramseier, H
AU  - Ramseier H
FAU - Lichtensteiger, W
AU  - Lichtensteiger W
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Life Sci
JT  - Life sciences
JID - 0375521
RN  - 0 (Receptors, GABA-A)
RN  - 5PE9FDE8GB (Clonazepam)
RN  - Q3JTX2Q7TU (Diazepam)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Animals
MH  - Clonazepam/toxicity
MH  - Corticosterone/blood
MH  - Diazepam/*toxicity
MH  - Female
MH  - Fetus/*drug effects
MH  - Immunity, Cellular/*drug effects
MH  - Lymphocyte Activation/drug effects
MH  - Male
MH  - Pregnancy
MH  - Rats
MH  - Receptors, GABA-A/drug effects
MH  - T-Lymphocytes/drug effects
EDAT- 1989/01/01 00:00
MHDA- 1989/01/01 00:01
CRDT- 1989/01/01 00:00
PHST- 1989/01/01 00:00 [pubmed]
PHST- 1989/01/01 00:01 [medline]
PHST- 1989/01/01 00:00 [entrez]
AID - 0024-3205(89)90465-7 [pii]
AID - 10.1016/0024-3205(89)90465-7 [doi]
PST - ppublish
SO  - Life Sci. 1989;44(7):493-501. doi: 10.1016/0024-3205(89)90465-7.