PMID- 25387671
OWN - NLM
STAT- MEDLINE
DCOM- 20150714
LR  - 20220321
IS  - 1414-431X (Electronic)
IS  - 0100-879X (Print)
IS  - 0100-879X (Linking)
VI  - 47
IP  - 12
DP  - 2014 Dec
TI  - Possible roles of COX-1 in learning and memory impairment induced by traumatic 
      brain injury in mice.
PG  - 1050-6
LID - S0100-879X2014001201050 [pii]
AB  - People who suffer from traumatic brain injury (TBI) often experience cognitive 
      deficits in spatial reference and working memory. The possible roles of 
      cyclooxygenase-1 (COX-1) in learning and memory impairment in mice with TBI are 
      far from well known. Adult mice subjected to TBI were treated with the COX-1 
      selective inhibitor SC560. Performance in the open field and on the beam walk was 
      then used to assess motor and behavioral function 1, 3, 7, 14, and 21 days 
      following injury. Acquisition of spatial learning and memory retention was 
      assessed using the Morris water maze on day 15 post-TBI. The expressions of 
      COX-1, prostaglandin E2 (PGE2), interleukin (IL)-6, brain-derived neurotrophic 
      factor (BDNF), platelet-derived growth factor BB (PDGF-BB), synapsin-I, and 
      synaptophysin were detected in TBI mice. Administration of SC560 improved 
      performance of beam walk tasks as well as spatial learning and memory after TBI. 
      SC560 also reduced expressions of inflammatory markers IL-6 and PGE2, and 
      reversed the expressions of COX-1, BDNF, PDGF-BB, synapsin-I, and synaptophysin 
      in TBI mice. The present findings demonstrated that COX-1 might play an important 
      role in cognitive deficits after TBI and that selective COX-1 inhibition should 
      be further investigated as a potential therapeutic approach for TBI.
FAU - Shang, J L
AU  - Shang JL
AD  - Neurology Department, Peace Hospital Attached to Changzhi Medical College, 
      Changzhi, China.
FAU - Cheng, Q
AU  - Cheng Q
AD  - Neurology Department, Changzhi City People's Hospital, Changzhi, China.
FAU - Yang, W F
AU  - Yang WF
AD  - Neurology Department, People's Hospital of Dali, Dali, China.
FAU - Zhang, M
AU  - Zhang M
AD  - Neurology Department, Peace Hospital Attached to Changzhi Medical College, 
      Changzhi, China.
FAU - Cui, Y
AU  - Cui Y
AD  - Neurology Department, Peace Hospital Attached to Changzhi Medical College, 
      Changzhi, China.
FAU - Wang, Y F
AU  - Wang YF
AD  - Neurology Department, Peace Hospital Attached to Changzhi Medical College, 
      Changzhi, China.
LA  - eng
PT  - Journal Article
DEP - 20140916
PL  - Brazil
TA  - Braz J Med Biol Res
JT  - Brazilian journal of medical and biological research = Revista brasileira de 
      pesquisas medicas e biologicas
JID - 8112917
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Cyclooxygenase Inhibitors)
RN  - 0 (Interleukin-6)
RN  - 0 (Proto-Oncogene Proteins c-sis)
RN  - 0 (Pyrazoles)
RN  - 0 (SC 560)
RN  - 0 (Synaptophysin)
RN  - 1B56C968OA (Becaplermin)
RN  - EC 1.14.99.1 (Cyclooxygenase 1)
RN  - K7Q1JQR04M (Dinoprostone)
SB  - IM
MH  - Animals
MH  - Becaplermin
MH  - Blotting, Western
MH  - Brain Injuries/*complications
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Cerebral Cortex/*injuries
MH  - Cerebral Decortication
MH  - Cyclooxygenase 1/metabolism/*physiology
MH  - Cyclooxygenase Inhibitors/*therapeutic use
MH  - Dinoprostone/analysis/metabolism
MH  - Disease Models, Animal
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Hippocampus/metabolism
MH  - Interleukin-6/blood
MH  - Learning/*drug effects
MH  - Maze Learning/drug effects
MH  - Memory Disorders/*drug therapy/etiology/metabolism
MH  - Mice, Inbred C57BL
MH  - Proto-Oncogene Proteins c-sis/metabolism
MH  - Pyrazoles/*therapeutic use
MH  - Recovery of Function/drug effects
MH  - Synaptophysin/analysis/metabolism
PMC - PMC4244670
EDAT- 2014/11/13 06:00
MHDA- 2015/07/15 06:00
PMCR- 2014/09/16
CRDT- 2014/11/13 06:00
PHST- 2013/10/09 00:00 [received]
PHST- 2014/06/23 00:00 [accepted]
PHST- 2014/11/13 06:00 [entrez]
PHST- 2014/11/13 06:00 [pubmed]
PHST- 2015/07/15 06:00 [medline]
PHST- 2014/09/16 00:00 [pmc-release]
AID - S0100-879X2014001201050 [pii]
AID - 10.1590/1414-431X20143601 [doi]
PST - ppublish
SO  - Braz J Med Biol Res. 2014 Dec;47(12):1050-6. doi: 10.1590/1414-431X20143601. Epub 
      2014 Sep 16.