PMID- 25387785
OWN - NLM
STAT- MEDLINE
DCOM- 20160222
LR  - 20220316
IS  - 1435-1463 (Electronic)
IS  - 0300-9564 (Linking)
VI  - 122
IP  - 6
DP  - 2015 Jun
TI  - BDNF serum levels and promoter methylation of BDNF exon I, IV and VI in depressed 
      patients receiving electroconvulsive therapy.
PG  - 925-8
LID - 10.1007/s00702-014-1336-6 [doi]
AB  - We examined potential changes in brain-derived neurotrophic factor (BDNF) serum 
      levels and promoter methylation of the BDNF gene in 11 patients with 
      treatment-resistant major depressive disorder during a series of 
      electroconvulsive therapy (ECT). Blood samples were taken before, 1 and 24 h 
      after ECT treatment sessions 1, 4, 7 and 10. Patients remitting under ECT had 
      significantly lower mean promoter methylation rates, especially concerning the 
      exon I promoter, compared to non-remitters (both p < 0.002). These findings may 
      point to a depression subtype in which ECT is particularly beneficial.
FAU - Kleimann, Alexandra
AU  - Kleimann A
AD  - Laboratory for Molecular Neuroscience, Department of Psychiatry, Social 
      Psychiatry and Psychotherapy, Hannover Medical School (MHH), Carl-Neubergstr. 1, 
      30625, Hannover, Germany, kleimann.alexandra@mh-hannover.de.
FAU - Kotsiari, Alexandra
AU  - Kotsiari A
FAU - Sperling, Wolfgang
AU  - Sperling W
FAU - Groschl, Michael
AU  - Groschl M
FAU - Heberlein, Annemarie
AU  - Heberlein A
FAU - Kahl, Kai G
AU  - Kahl KG
FAU - Hillemacher, Thomas
AU  - Hillemacher T
FAU - Bleich, Stefan
AU  - Bleich S
FAU - Kornhuber, Johannes
AU  - Kornhuber J
FAU - Frieling, Helge
AU  - Frieling H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141112
PL  - Austria
TA  - J Neural Transm (Vienna)
JT  - Journal of neural transmission (Vienna, Austria : 1996)
JID - 9702341
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Brain-Derived Neurotrophic Factor/*blood/*genetics
MH  - *DNA Methylation
MH  - Depressive Disorder, Major/blood/genetics/*therapy
MH  - Depressive Disorder, Treatment-Resistant/blood/genetics/*therapy
MH  - *Electroconvulsive Therapy
MH  - Exons
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Promoter Regions, Genetic
MH  - Prospective Studies
MH  - Treatment Outcome
EDAT- 2014/11/13 06:00
MHDA- 2016/02/24 06:00
CRDT- 2014/11/13 06:00
PHST- 2014/07/16 00:00 [received]
PHST- 2014/11/05 00:00 [accepted]
PHST- 2014/11/13 06:00 [entrez]
PHST- 2014/11/13 06:00 [pubmed]
PHST- 2016/02/24 06:00 [medline]
AID - 10.1007/s00702-014-1336-6 [doi]
PST - ppublish
SO  - J Neural Transm (Vienna). 2015 Jun;122(6):925-8. doi: 10.1007/s00702-014-1336-6. 
      Epub 2014 Nov 12.