PMID- 25388018 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20141112 LR - 20201001 IS - 1523-3847 (Print) IS - 1523-3847 (Linking) VI - 16 IP - 12 DP - 2014 Dec TI - Use of intravenous immunoglobulin in critically ill patients. PG - 447 LID - 10.1007/s11908-014-0447-4 [doi] AB - Intravenous immunoglobulin (IVIG) has been suggested for the treatment of many ailments due to its ability to modulate the immune system and to provide passive immunity to commonly circulating pathogens. Its use as primary and adjunctive therapy for the treatment of conditions affecting critically ill patients is an attractive option, especially when alternative therapy does not exist. The body of literature on the use of IVIG for the treatment of several serious conditions, including sepsis, toxic shock syndrome, acute myocarditis, Stevens-Johnson syndrome, toxic epidermal necrolysis, and H1N1 influenza, were reviewed. Despite advances in treatment of these conditions since they were first described, there remains a paucity of well-designed studies on the use of IVIG for their treatment. Therefore, the use of IVIG for treatment of these conditions remains controversial. FAU - Donovan, Summer AU - Donovan S AD - Pediatric Infectious Diseases Fellow, Virginia Commonwealth University Health System, VCU Sanger Hall 12-041, P.O. Box 980163, Richmond, VA, 23298-0163, USA, sdonovan@mcvh-vcu.edu. FAU - Bearman, Gonzalo M L AU - Bearman GM LA - eng PT - Journal Article PL - United States TA - Curr Infect Dis Rep JT - Current infectious disease reports JID - 100888983 EDAT- 2014/11/13 06:00 MHDA- 2014/11/13 06:01 CRDT- 2014/11/13 06:00 PHST- 2014/11/13 06:00 [entrez] PHST- 2014/11/13 06:00 [pubmed] PHST- 2014/11/13 06:01 [medline] AID - 10.1007/s11908-014-0447-4 [doi] PST - ppublish SO - Curr Infect Dis Rep. 2014 Dec;16(12):447. doi: 10.1007/s11908-014-0447-4.