PMID- 25388677
OWN - NLM
STAT- MEDLINE
DCOM- 20150410
LR  - 20181113
IS  - 1559-7016 (Electronic)
IS  - 0271-678X (Print)
IS  - 0271-678X (Linking)
VI  - 35
IP  - 2
DP  - 2015 Feb
TI  - Effect of age and vascular anatomy on blood flow in major cerebral vessels.
PG  - 312-8
LID - 10.1038/jcbfm.2014.203 [doi]
AB  - Measurement of volume flow rates in major cerebral vessels can be used to 
      evaluate the hemodynamic effects of cerebrovascular disease. However, both age 
      and vascular anatomy can affect flow rates independent of disease. We 
      prospectively evaluated 325 healthy adult volunteers using phase contrast 
      quantitative magnetic resonance angiography to characterize these effects on 
      cerebral vessel flow rates and establish clinically useful normative reference 
      values. Flows were measured in the major intracranial and extracranial vessels. 
      The cohort ranged from 18 to 84 years old, with 157 (48%) females. All individual 
      vessel flows and total cerebral blood flow (TCBF) declined with age, at 
      2.6 mL/minute per year for TCBF. Basilar artery (BA) flow was significantly 
      decreased in individuals with one or both fetal posterior cerebral arteries 
      (PCAs). Internal carotid artery flows were significantly higher with a fetal PCA 
      and decreased with a hypoplastic anterior cerebral artery. Indexing vessel flows 
      to TCBF neutralized the age effect, but anatomic variations continued to impact 
      indexed flow in the BA and internal carotid artery. Variability in normative flow 
      ranges were reduced in distal vessels and by examining regional flows. Cerebral 
      vessel flows are affected by age and cerebrovascular anatomy, which has important 
      implications for interpretation of flows in the disease state.
FAU - Amin-Hanjani, Sepideh
AU  - Amin-Hanjani S
AD  - Department of Neurosurgery, University of Illinois at Chicago, Chicago, Illinois, 
      USA.
FAU - Du, Xinjian
AU  - Du X
AD  - Department of Neurosurgery, University of Illinois at Chicago, Chicago, Illinois, 
      USA.
FAU - Pandey, Dilip K
AU  - Pandey DK
AD  - Department of Neurology and Rehabilitation Medicine, University of Illinois at 
      Chicago, Chicago, Illinois, USA.
FAU - Thulborn, Keith R
AU  - Thulborn KR
AD  - Center for Magnetic Resonance Research, University of Illinois at Chicago, 
      Chicago, Illinois, USA.
FAU - Charbel, Fady T
AU  - Charbel FT
AD  - Department of Neurosurgery, University of Illinois at Chicago, Chicago, Illinois, 
      USA.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141112
PL  - United States
TA  - J Cereb Blood Flow Metab
JT  - Journal of cerebral blood flow and metabolism : official journal of the 
      International Society of Cerebral Blood Flow and Metabolism
JID - 8112566
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Aging/*physiology
MH  - Blood Flow Velocity/physiology
MH  - *Carotid Artery, Internal/anatomy & histology/physiology
MH  - Cerebral Angiography
MH  - *Cerebral Arteries/anatomy & histology/physiology
MH  - Cerebrovascular Circulation/*physiology
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Angiography
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
PMC - PMC4426749
EDAT- 2014/11/13 06:00
MHDA- 2015/04/11 06:00
PMCR- 2016/02/01
CRDT- 2014/11/13 06:00
PHST- 2014/06/20 00:00 [received]
PHST- 2014/09/21 00:00 [revised]
PHST- 2014/10/16 00:00 [accepted]
PHST- 2014/11/13 06:00 [entrez]
PHST- 2014/11/13 06:00 [pubmed]
PHST- 2015/04/11 06:00 [medline]
PHST- 2016/02/01 00:00 [pmc-release]
AID - jcbfm2014203 [pii]
AID - 10.1038/jcbfm.2014.203 [doi]
PST - ppublish
SO  - J Cereb Blood Flow Metab. 2015 Feb;35(2):312-8. doi: 10.1038/jcbfm.2014.203. Epub 
      2014 Nov 12.