PMID- 25388867
OWN - NLM
STAT- MEDLINE
DCOM- 20150330
LR  - 20240117
IS  - 1532-429X (Electronic)
IS  - 1097-6647 (Print)
IS  - 1097-6647 (Linking)
VI  - 16
IP  - 1
DP  - 2014 Nov 12
TI  - In vivo cardiovascular magnetic resonance diffusion tensor imaging shows evidence 
      of abnormal myocardial laminar orientations and mobility in hypertrophic 
      cardiomyopathy.
PG  - 87
LID - 10.1186/s12968-014-0087-8 [doi]
LID - 87
AB  - BACKGROUND: Cardiac diffusion tensor imaging (cDTI) measures the magnitudes and 
      directions of intramyocardial water diffusion. Assuming the cross-myocyte 
      components to be constrained by the laminar microstructures of myocardium, we 
      hypothesized that cDTI at two cardiac phases might identify any abnormalities of 
      laminar orientation and mobility in hypertrophic cardiomyopathy (HCM). METHODS: 
      We performed cDTI in vivo at 3 Tesla at end-systole and late diastole in 11 
      healthy controls and 11 patients with HCM, as well as late gadolinium enhancement 
      (LGE) for detection of regional fibrosis. RESULTS: Voxel-wise analysis of 
      diffusion tensors relative to left ventricular coordinates showed expected 
      transmural changes of myocardial helix-angle, with no significant differences 
      between phases or between HCM and control groups. In controls, the angle of the 
      second eigenvector of diffusion (E2A) relative to the local wall tangent plane 
      was larger in systole than diastole, in accord with previously reported changes 
      of laminar orientation. HCM hearts showed higher than normal global E2A in 
      systole (63.9 degrees  vs 56.4 degrees  controls, p=0.026) and markedly raised E2A in diastole 
      (46.8 degrees  vs 24.0 degrees  controls, p<0.001). In hypertrophic regions, E2A retained a high, 
      systole-like angulation even in diastole, independent of LGE, while regions of 
      normal wall thickness did not (LGE present 57.8 degrees , p=0.0028, LGE absent 54.8 degrees , 
      p=0.0022 vs normal thickness 38.1 degrees ). CONCLUSIONS: In healthy controls, the angles 
      of cross-myocyte components of diffusion were consistent with previously reported 
      transmural orientations of laminar microstructures and their changes with 
      contraction. In HCM, especially in hypertrophic regions, they were consistent 
      with hypercontraction in systole and failure of relaxation in diastole. Further 
      investigation of this finding is required as previously postulated effects of 
      strain might be a confounding factor.
FAU - Ferreira, Pedro F
AU  - Ferreira PF
FAU - Kilner, Philip J
AU  - Kilner PJ
FAU - McGill, Laura-Ann
AU  - McGill LA
FAU - Nielles-Vallespin, Sonia
AU  - Nielles-Vallespin S
FAU - Scott, Andrew D
AU  - Scott AD
FAU - Ho, Siew Y
AU  - Ho SY
FAU - McCarthy, Karen P
AU  - McCarthy KP
FAU - Haba, Margarita M
AU  - Haba MM
FAU - Ismail, Tevfik F
AU  - Ismail TF
FAU - Gatehouse, Peter D
AU  - Gatehouse PD
FAU - de Silva, Ranil
AU  - de Silva R
FAU - Lyon, Alexander R
AU  - Lyon AR
FAU - Prasad, Sanjay K
AU  - Prasad SK
FAU - Firmin, David N
AU  - Firmin DN
AD  - National Institute of Health Research Cardiovascular Biomedical Research Unit, 
      Royal Brompton Hospital and Imperial College, London, UK. d.firmin@ic.ac.uk.
FAU - Pennell, Dudley J
AU  - Pennell DJ
LA  - eng
GR  - FS/11/67/28954/BHF_/British Heart Foundation/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141112
PL  - England
TA  - J Cardiovasc Magn Reson
JT  - Journal of cardiovascular magnetic resonance : official journal of the Society 
      for Cardiovascular Magnetic Resonance
JID - 9815616
SB  - IM
CIN - J Cardiovasc Magn Reson. 2014;16:89. PMID: 25388937
MH  - Aged
MH  - Cardiomyopathy, Hypertrophic/*diagnosis/pathology/physiopathology
MH  - Case-Control Studies
MH  - *Diffusion Magnetic Resonance Imaging
MH  - *Diffusion Tensor Imaging
MH  - Female
MH  - Fibrosis
MH  - Humans
MH  - Image Interpretation, Computer-Assisted
MH  - *Magnetic Resonance Imaging, Cine
MH  - Male
MH  - Middle Aged
MH  - *Myocardial Contraction
MH  - Myocardium/*pathology
MH  - Predictive Value of Tests
MH  - *Ventricular Function, Left
PMC - PMC4229618
EDAT- 2014/11/13 06:00
MHDA- 2015/03/31 06:00
PMCR- 2014/11/12
CRDT- 2014/11/13 06:00
PHST- 2014/03/03 00:00 [received]
PHST- 2014/09/24 00:00 [accepted]
PHST- 2014/11/13 06:00 [entrez]
PHST- 2014/11/13 06:00 [pubmed]
PHST- 2015/03/31 06:00 [medline]
PHST- 2014/11/12 00:00 [pmc-release]
AID - S1097-6647(23)00154-0 [pii]
AID - 87 [pii]
AID - 10.1186/s12968-014-0087-8 [doi]
PST - epublish
SO  - J Cardiovasc Magn Reson. 2014 Nov 12;16(1):87. doi: 10.1186/s12968-014-0087-8.