PMID- 25388945
OWN - NLM
STAT- MEDLINE
DCOM- 20150915
LR  - 20231214
IS  - 1880-6562 (Electronic)
IS  - 1880-6546 (Print)
IS  - 1880-6546 (Linking)
VI  - 65
IP  - 1
DP  - 2015 Jan
TI  - A comparison of chronic AICAR treatment-induced metabolic adaptations in red and 
      white muscles of rats.
PG  - 121-30
LID - 10.1007/s12576-014-0349-0 [doi]
AB  - The signaling molecule 5'-AMP-activated protein kinase plays a pivotal role in 
      metabolic adaptations. Treatment with 
      5-aminoimidazole-4-carboxamide-1-beta-D-ribofranoside (AICAR) promotes the 
      expression of metabolic regulators and components involved in glucose uptake, 
      mitochondrial biogenesis, and fatty acid oxidation in skeletal muscle cells. Our 
      aim was to determine whether AICAR-induced changes in metabolic regulators and 
      components were more prominent in white or red muscle. Rats were treated with 
      AICAR (1 mg/g body weight/day) for 14 days, resulting in increased expression 
      levels of nicotinamide phosphoribosyltransferase (NAMPT), peroxisome 
      proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha), glucose transporter 4 
      proteins, and enhanced mitochondrial biogenesis. These changes were more 
      prominent in white rather than red gastrocnemius muscle or were only observed in 
      the white gastrocnemius. Our results suggest that AICAR induces the expression of 
      metabolic regulators and components, especially in type II (B) fibers.
FAU - Suwa, Masataka
AU  - Suwa M
AD  - Faculty of Life Design, Tohoku Institute of Technology, 6 Futatsusawa, 
      Taihaku-ku, Sendai, Miyagi, 982-8588, Japan, suwa-m@tohtech.ac.jp.
FAU - Nakano, Hiroshi
AU  - Nakano H
FAU - Radak, Zsolt
AU  - Radak Z
FAU - Kumagai, Shuzo
AU  - Kumagai S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141112
PL  - Japan
TA  - J Physiol Sci
JT  - The journal of physiological sciences : JPS
JID - 101262417
RN  - 0 (Cytokines)
RN  - 0 (Glucose Transporter Type 4)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha)
RN  - 0 (Ppargc1a protein, rat)
RN  - 0 (Ribonucleotides)
RN  - 0 (Slc2a4 protein, rat)
RN  - 0 (Transcription Factors)
RN  - 360-97-4 (Aminoimidazole Carboxamide)
RN  - EC 2.4.2.12 (Nicotinamide Phosphoribosyltransferase)
RN  - EC 2.4.2.12 (nicotinamide phosphoribosyltransferase, rat)
RN  - EC 2.7.11.31 (AMP-Activated Protein Kinases)
RN  - EC 3.5.1.- (Sirt1 protein, rat)
RN  - EC 3.5.1.- (Sirtuin 1)
RN  - F0X88YW0YK (AICA ribonucleotide)
SB  - IM
MH  - AMP-Activated Protein Kinases/metabolism
MH  - Adaptation, Physiological/drug effects
MH  - Aminoimidazole Carboxamide/*analogs & derivatives/pharmacology
MH  - Animals
MH  - Cytokines/metabolism
MH  - Glucose Transporter Type 4/metabolism
MH  - Hypoglycemic Agents/pharmacology
MH  - Male
MH  - Muscle Fibers, Fast-Twitch/drug effects/metabolism
MH  - Muscle Fibers, Slow-Twitch/drug effects/metabolism
MH  - Muscle, Skeletal/*drug effects/*metabolism
MH  - Nicotinamide Phosphoribosyltransferase/metabolism
MH  - Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
MH  - Rats
MH  - Rats, Wistar
MH  - Ribonucleotides/*pharmacology
MH  - Sirtuin 1/metabolism
MH  - Transcription Factors/metabolism
PMC - PMC10717678
COIS- We have no conflicts of interest to declare.
EDAT- 2014/11/13 06:00
MHDA- 2015/09/16 06:00
PMCR- 2014/11/12
CRDT- 2014/11/13 06:00
PHST- 2014/03/26 00:00 [received]
PHST- 2014/10/30 00:00 [accepted]
PHST- 2014/11/13 06:00 [entrez]
PHST- 2014/11/13 06:00 [pubmed]
PHST- 2015/09/16 06:00 [medline]
PHST- 2014/11/12 00:00 [pmc-release]
AID - 349 [pii]
AID - 10.1007/s12576-014-0349-0 [doi]
PST - ppublish
SO  - J Physiol Sci. 2015 Jan;65(1):121-30. doi: 10.1007/s12576-014-0349-0. Epub 2014 
      Nov 12.