PMID- 25389088
OWN - NLM
STAT- MEDLINE
DCOM- 20160114
LR  - 20150413
IS  - 1440-1746 (Electronic)
IS  - 0815-9319 (Linking)
VI  - 30
IP  - 5
DP  - 2015 May
TI  - SNP rs7770370 in HLA-DPB1 loci as a major genetic determinant of response to 
      booster hepatitis B vaccination: results of a genome-wide association study.
PG  - 891-9
LID - 10.1111/jgh.12845 [doi]
AB  - BACKGROUND AND AIM: Hepatitis B (HB) vaccination is highly effective in reducing 
      the risk of hepatitis B virus infection. However, breakthrough and chronic 
      hepatitis B virus infections in vaccinated subjects raised concern about its 
      long-term efficacy. The specific aim of the study was to explore the host genetic 
      determinants of long-term immunological memory against HB vaccination. METHODS: 
      We conducted a case-control study nested in a cohort of HB booster recipients who 
      had received primary HB vaccination during infancy but failed to reside an 
      anti-HBs titers >/= 10 mIU/mL at the age of 15-18 years. We used a genome-wide 
      single nucleotide polymorphism (SNP) array plate to scan autosomal chromosomes 
      and assayed the human leukocyte antigen (HLA)-DPB1 genotype by sequence-based 
      techniques. RESULTS: We found that 10 of the 112 candidate SNPs 
      (P-value < 5.0 x 10(-5) ) clustered within a 47-Kb region of the HLA-DP loci. All 
      the minor alleles of these HLA-DP candidate SNPs were correlated with lower 
      likelihoods of nonresponse to HB vaccine. There was a significant linkage 
      disequilibrium between these HLA-DP candidate SNPs and HLA-DPB1 protective 
      alleles. Multivariate analyses showed that rs7770370 was the most significant 
      genetic factor. As compared with rs7770370 GG homozygotes, adjusted odds ratios 
      were 0.524 (95% confidence interval, 0.276-0.993) and 0.095 (95% confidence 
      interval, 0.030-0.307) for AG heterozygotes and AA homozygotes, respectively. 
      CONCLUSION: Our results showed that rs7770370 was the most significant genetic 
      factor of response to HB booster. The rs7770370 and nearby SNPs may also 
      contribute to the long-term immunological memory against HB vaccination.
CI  - (c) 2014 Journal of Gastroenterology and Hepatology Foundation and Wiley Publishing 
      Asia Pty Ltd.
FAU - Wu, Tzu-Wei
AU  - Wu TW
AD  - Department of Medicine, Mackay Medical College, New Taipei City, Taiwan.
FAU - Chen, Chuen-Fei
AU  - Chen CF
FAU - Lai, Sheng-Kai
AU  - Lai SK
FAU - Lin, Hans Hsienhong
AU  - Lin HH
FAU - Chu, Chen-Chung
AU  - Chu CC
FAU - Wang, Li-Yu
AU  - Wang LY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Australia
TA  - J Gastroenterol Hepatol
JT  - Journal of gastroenterology and hepatology
JID - 8607909
RN  - 0 (HLA-DP beta-Chains)
RN  - 0 (HLA-DPB1 antigen)
RN  - 0 (Hepatitis B Vaccines)
SB  - IM
MH  - Adolescent
MH  - Alleles
MH  - Case-Control Studies
MH  - Cohort Studies
MH  - Female
MH  - *Genome-Wide Association Study
MH  - Genotyping Techniques
MH  - HLA-DP beta-Chains/*genetics
MH  - Hepatitis B/*immunology/*prevention & control
MH  - Hepatitis B Vaccines/*immunology
MH  - Humans
MH  - *Immunization, Secondary
MH  - Immunologic Memory/*genetics
MH  - Infant
MH  - Male
MH  - Multivariate Analysis
MH  - *Polymorphism, Single Nucleotide
MH  - Risk
MH  - Time Factors
OTO - NOTNLM
OT  - HLA-DP
OT  - adolescents
OT  - genome-wide association study
OT  - hepatitis B vaccination
EDAT- 2014/11/13 06:00
MHDA- 2016/01/15 06:00
CRDT- 2014/11/13 06:00
PHST- 2014/11/04 00:00 [accepted]
PHST- 2014/11/13 06:00 [entrez]
PHST- 2014/11/13 06:00 [pubmed]
PHST- 2016/01/15 06:00 [medline]
AID - 10.1111/jgh.12845 [doi]
PST - ppublish
SO  - J Gastroenterol Hepatol. 2015 May;30(5):891-9. doi: 10.1111/jgh.12845.