PMID- 25390683
OWN - NLM
STAT- MEDLINE
DCOM- 20151019
LR  - 20181113
IS  - 1999-4915 (Electronic)
IS  - 1999-4915 (Linking)
VI  - 6
IP  - 11
DP  - 2014 Nov 10
TI  - A unique evolution of the s2 gene of equine infectious anemia virus in hosts 
      correlated with particular infection statuses.
PG  - 4265-79
LID - 10.3390/v6114265 [doi]
AB  - Equine infectious anemia virus (EIAV) is a member of the Lentivirus genus in the 
      Retroviridae family that exhibits a genomic structure similar to that of HIV-1. 
      The S2 accessory proteins play important roles in viral replication in vivo and 
      in viral pathogenicity; however, studies on S2 evolution in vivo are limited. 
      This study analyzed the evolutionary characteristics of the S2 gene of a 
      pathogenic EIAV strain, EIAVLN40, in four experimentally infected horses. The 
      results demonstrated that 14.7% (10 of 68 residues) of the stable amino acid 
      mutations occurred longitudinally in S2 during a 150-day infection period. 
      Further analysis revealed that six of the ten mutated residues were positively 
      selected during the infection. Alignment and phylogenetic analyses showed that 
      the S2 gene sequences of viruses isolated from the infected horses at the early 
      stage of EIAVLN40 infection were highly homologous and similar to the 
      vaccine-specific sequence. The S2 gene variants isolated from the febrile 
      episodes and late phase of infection became homologous to the S2 gene sequence of 
      the inoculating EIAVLN40 strain. Our results indicate that the S2 gene evolves in 
      diversity and divergence in vivo in different stages of EIAV infection and that 
      this evolution correlates with the pathogenicity of the virus.
FAU - Wang, Xue-Feng
AU  - Wang XF
AD  - State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research 
      Institute of Chinese Academy of Agricultural Sciences, Harbin 150001, China. 
      xuefengwang1982@126.com.
FAU - Wang, Shuai
AU  - Wang S
AD  - State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research 
      Institute of Chinese Academy of Agricultural Sciences, Harbin 150001, China. 
      8111781252@163.com.
FAU - Liu, Qiang
AU  - Liu Q
AD  - State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research 
      Institute of Chinese Academy of Agricultural Sciences, Harbin 150001, China. 
      liuqiangtriumph@163.com.
FAU - Lin, Yue-Zhi
AU  - Lin YZ
AD  - State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research 
      Institute of Chinese Academy of Agricultural Sciences, Harbin 150001, China. 
      sndhr@163.com.
FAU - Du, Cheng
AU  - Du C
AD  - State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research 
      Institute of Chinese Academy of Agricultural Sciences, Harbin 150001, China. 
      chengdu1981@163.com.
FAU - Tang, Yan-Dong
AU  - Tang YD
AD  - State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research 
      Institute of Chinese Academy of Agricultural Sciences, Harbin 150001, China. 
      tangyandong2008@163.com.
FAU - Na, Lei
AU  - Na L
AD  - State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research 
      Institute of Chinese Academy of Agricultural Sciences, Harbin 150001, China. 
      nl2zy@163.com.
FAU - Wang, Xiaojun
AU  - Wang X
AD  - State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research 
      Institute of Chinese Academy of Agricultural Sciences, Harbin 150001, China. 
      xjw@hvri.ac.cn.
FAU - Zhou, Jian-Hua
AU  - Zhou JH
AD  - State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research 
      Institute of Chinese Academy of Agricultural Sciences, Harbin 150001, China. 
      jianhua_uc@126.com.
LA  - eng
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PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141110
PL  - Switzerland
TA  - Viruses
JT  - Viruses
JID - 101509722
RN  - 0 (RNA, Viral)
RN  - 0 (S2 protein, Equine infectious anemia virus)
RN  - 0 (Viral Proteins)
SB  - IM
MH  - Animals
MH  - Equine Infectious Anemia/*virology
MH  - *Evolution, Molecular
MH  - *Genetic Variation
MH  - Genotype
MH  - Horses
MH  - Infectious Anemia Virus, Equine/*genetics/isolation & purification
MH  - Male
MH  - Molecular Sequence Data
MH  - Mutation
MH  - Phylogeny
MH  - RNA, Viral/genetics
MH  - Selection, Genetic
MH  - Sequence Analysis, DNA
MH  - Sequence Homology, Amino Acid
MH  - Time Factors
MH  - Viral Proteins/*genetics
PMC - PMC4246221
EDAT- 2014/11/13 06:00
MHDA- 2015/10/20 06:00
PMCR- 2014/11/01
CRDT- 2014/11/13 06:00
PHST- 2014/09/05 00:00 [received]
PHST- 2014/10/26 00:00 [revised]
PHST- 2014/10/29 00:00 [accepted]
PHST- 2014/11/13 06:00 [entrez]
PHST- 2014/11/13 06:00 [pubmed]
PHST- 2015/10/20 06:00 [medline]
PHST- 2014/11/01 00:00 [pmc-release]
AID - v6114265 [pii]
AID - viruses-06-04265 [pii]
AID - 10.3390/v6114265 [doi]
PST - epublish
SO  - Viruses. 2014 Nov 10;6(11):4265-79. doi: 10.3390/v6114265.