PMID- 25390763
OWN - NLM
STAT- MEDLINE
DCOM- 20150921
LR  - 20150107
IS  - 1943-3700 (Electronic)
IS  - 0090-3558 (Linking)
VI  - 51
IP  - 1
DP  - 2015 Jan
TI  - Coinfection and vertical transmission of Brucella and Morbillivirus in a neonatal 
      sperm whale (Physeter macrocephalus) in Hawaii, USA.
PG  - 227-32
LID - 10.7589/2014-04-092 [doi]
AB  - The viral genus Morbillivirus and the bacterial genus Brucella have emerged as 
      important groups of pathogens that are known to affect cetacean health on a 
      global scale, but neither pathogen has previously been reported from endangered 
      sperm whales (Physeter macrocephalus). A female neonate sperm whale stranded 
      alive and died near Laie on the island of Oahu, Hawaii, US, in May of 2011. 
      Congestion of the cerebrum and enlarged lymph nodes were noted on the gross 
      necropsy. Microscopic findings included lymphoid depletion, chronic meningitis, 
      and pneumonia, suggesting an in utero infection. Cerebrum, lung, umbilicus, and 
      select lymph nodes (tracheobronchial and mediastinal) were positive for Brucella 
      by PCR. Brucella sp. was also cultured from the cerebrum and from mediastinal and 
      tracheobronchial lymph nodes. Twelve different tissues were screened for 
      Morbillivirus by reverse-transcriptase (RT)-PCR and select tissues by 
      immunohistochemistry, but only the tracheobronchial lymph node and spleen were 
      positive by RT-PCR. Pathologic findings observed were likely a result of 
      Brucella, but Morbillivirus may have played a key role in immune suppression of 
      the mother and calf. The in utero infection in this individual strongly supports 
      vertical transmission of both pathogens.
FAU - West, Kristi L
AU  - West KL
AD  - 1 College of Natural and Computational Sciences, Hawaii Pacific University, 
      45-045 Kamehameha Hwy., Kaneohe, Hawaii 96744, USA.
FAU - Levine, Gregg
AU  - Levine G
FAU - Jacob, Jessica
AU  - Jacob J
FAU - Jensen, Brenda
AU  - Jensen B
FAU - Sanchez, Susan
AU  - Sanchez S
FAU - Colegrove, Kathleen
AU  - Colegrove K
FAU - Rotstein, David
AU  - Rotstein D
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Wildl Dis
JT  - Journal of wildlife diseases
JID - 0244160
SB  - IM
MH  - Animals
MH  - *Animals, Newborn
MH  - Brucella/*isolation & purification
MH  - Brucellosis/pathology/*veterinary
MH  - Fatal Outcome
MH  - Female
MH  - Hawaii
MH  - Infectious Disease Transmission, Vertical
MH  - Morbillivirus/*isolation & purification
MH  - Morbillivirus Infections/pathology/*veterinary
MH  - *Sperm Whale
OTO - NOTNLM
OT  - Brucella
OT  - Hawaii
OT  - Morbillivirus
OT  - brucellosis
OT  - coinfection
OT  - sperm whale
OT  - vertical transmission
EDAT- 2014/11/13 06:00
MHDA- 2015/09/22 06:00
CRDT- 2014/11/13 06:00
PHST- 2014/11/13 06:00 [entrez]
PHST- 2014/11/13 06:00 [pubmed]
PHST- 2015/09/22 06:00 [medline]
AID - 10.7589/2014-04-092 [doi]
PST - ppublish
SO  - J Wildl Dis. 2015 Jan;51(1):227-32. doi: 10.7589/2014-04-092.