PMID- 25391105
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150107
LR  - 20141113
IS  - 1937-1578 (Electronic)
IS  - 1935-1089 (Linking)
VI  - 7
IP  - 3
DP  - 2013 Summer
TI  - Features and surgical outcome of retinal nerve fiber layer alterations associated 
      with epiretinal membrane.
PG  - 198-203
LID - 10.1097/ICB.0b013e318280b047 [doi]
AB  - PURPOSE: In this study, the authors aimed to investigate structural abnormalities 
      in the retinal nerve fiber layer (RNFL) using spectral-domain optical coherence 
      tomography (SD-OCT) and study the surgical outcomes in eyes with such alterations 
      by comparing ultrastructure findings of the surgically excised epiretinal 
      membrane (ERM) and inner limiting membrane (ILM) in patients with idiopathic ERM. 
      METHODS AND PATIENTS: Vitreous surgery was performed on four eyes with idiopathic 
      ERM, of which three had columnar alterations of the nerve fiber layer. The ERM 
      and ILM were dissected and removed, and ultrathin sections were analyzed and 
      imaged completely by using electron microscopy. All the patients underwent a 
      comprehensive ophthalmologic examination, including SD-OCT, fundus-monitoring 
      microperimetry, and red-free scanning laser ophthalmoscopic imaging. RESULTS: 
      Preoperatively, SD-OCT revealed the presence of columnar structures only in the 
      RNFL. Transmission electron microscopy showed that all samples contained retinal 
      cell debris on the outer surface of the ILM. However, adhesion of retinal nerve 
      fibers on the outer surface of the ILM was not observed in any specimen. The 
      columnar alterations in the RNFL observed via SD-OCT resolved completely within 1 
      month in all eyes. At 6 months after surgery, no eyes showed scotoma on 
      microperimetry. Further, no dissociated nerve fiber layer appearance was 
      identified. CONCLUSION: Vitrectomy with ILM peeling can be safely performed for 
      ERMs with RNFL alterations, detected preoperatively by SD-OCT, without any 
      structural or functional disturbances. The columnar alterations of the RNFL on 
      SD-OCT may be inner retinoschisis.
FAU - Ozeki-Jingami, Yoko
AU  - Ozeki-Jingami Y
AD  - Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School 
      of Medicine, Kyoto, Japan.
FAU - Ooto, Sotaro
AU  - Ooto S
FAU - Hangai, Masanori
AU  - Hangai M
FAU - Tsujikawa, Akitaka
AU  - Tsujikawa A
FAU - Yoshimura, Nagahisa
AU  - Yoshimura N
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Retin Cases Brief Rep
JT  - Retinal cases & brief reports
JID - 101298744
EDAT- 2013/07/01 00:00
MHDA- 2013/07/01 00:01
CRDT- 2014/11/13 06:00
PHST- 2014/11/13 06:00 [entrez]
PHST- 2013/07/01 00:00 [pubmed]
PHST- 2013/07/01 00:01 [medline]
AID - 01271216-201300730-00006 [pii]
AID - 10.1097/ICB.0b013e318280b047 [doi]
PST - ppublish
SO  - Retin Cases Brief Rep. 2013 Summer;7(3):198-203. doi: 
      10.1097/ICB.0b013e318280b047.