PMID- 25391628
OWN - NLM
STAT- MEDLINE
DCOM- 20150723
LR  - 20181113
IS  - 1573-2606 (Electronic)
IS  - 1389-9155 (Linking)
VI  - 15
IP  - 4
DP  - 2014 Dec
TI  - Metabolic syndrome and the environmental pollutants from mitochondrial 
      perspectives.
PG  - 253-62
LID - 10.1007/s11154-014-9297-5 [doi]
AB  - The worldwide epidemic of diabetes and metabolic syndrome in the last few decades 
      cannot be fully accounted for only by changes in the lifestyle factors, such as 
      sedentary lifestyle and overeating. Besides genetic factors, there must be other 
      causes to explain this rapid change. They could not be infectious in nature and 
      induce insulin resistance as key biochemical abnormality. Mitochondrial 
      dysfunction could be underlying mechanism behind the insulin resistance, thus 
      metabolic syndrome. Then there have been increasing number of reports suggesting 
      that chronic exposure to and accumulation of endocrine disrupting chemicals 
      (EDCs), especially so-called the persistent organic pollutants (POPs) within the 
      body might be associated with metabolic syndrome. Combining two concepts, we 
      developed new "EDCs-induced mitochondrial dysfunction hypothesis of metabolic 
      syndrome". In this review we suggest that classifying those chemicals into 5 
      groups might be clinically useful considering their removal or avoidance; POPs, 
      non-persistent organic pollutants, heavy metals, air pollutants and drugs. We 
      will also discuss briefly how those insights could be applied to clinical 
      medicine.
FAU - Kim, Jin Taek
AU  - Kim JT
AD  - Department of Internal Medicine, College of Medicine, Eulji University, Seoul, 
      South Korea.
FAU - Lee, Hong Kyu
AU  - Lee HK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Germany
TA  - Rev Endocr Metab Disord
JT  - Reviews in endocrine & metabolic disorders
JID - 100940588
RN  - 0 (Endocrine Disruptors)
RN  - 0 (Environmental Pollutants)
SB  - IM
MH  - Endocrine Disruptors/*adverse effects
MH  - Environmental Pollutants/*adverse effects
MH  - Humans
MH  - Insulin Resistance
MH  - Metabolic Syndrome/*etiology/metabolism
MH  - Mitochondria/*drug effects/metabolism
EDAT- 2014/11/14 06:00
MHDA- 2015/07/24 06:00
CRDT- 2014/11/14 06:00
PHST- 2014/11/14 06:00 [entrez]
PHST- 2014/11/14 06:00 [pubmed]
PHST- 2015/07/24 06:00 [medline]
AID - 10.1007/s11154-014-9297-5 [doi]
PST - ppublish
SO  - Rev Endocr Metab Disord. 2014 Dec;15(4):253-62. doi: 10.1007/s11154-014-9297-5.