PMID- 25391998
OWN - NLM
STAT- MEDLINE
DCOM- 20150924
LR  - 20220408
IS  - 1471-2334 (Electronic)
IS  - 1471-2334 (Linking)
VI  - 14
DP  - 2014 Nov 13
TI  - Catheter-related Candida bloodstream infection in intensive care unit patients: a 
      subgroup analysis of the China-SCAN study.
PG  - 594
LID - 10.1186/s12879-014-0594-0 [doi]
LID - 594
AB  - BACKGROUND: In patients hospitalized in intensive care units (ICU), Candida 
      infections are associated with increased morbidity, mortality and costs. However, 
      previous studies reported confused risk factors for catheter-related Candida 
      bloodstream infection (CRCBSI). The objective was to describe the risk factors, 
      microbiology, management and outcomes of CRCBSI in the China-SCAN population. 
      METHODS: Patients with >/=1 Candida-positive peripheral blood culture were selected 
      from the China-SCAN study. Peripheral and catheter blood samples were collected 
      for Candida isolation. Patients with the same strain of Candida in peripheral and 
      catheter blood samples were considered as being with CRCBSI, while patients with 
      Candida-positive peripheral blood cultures only or different strains were 
      considered as non-CRCBSI. Data were collected from the China-SCAN study. RESULTS: 
      CRCBSI incidence in ICU was 0.03% (29/96,060), accounting for 9.86% of all 
      candidemia observed in ICU (29/294). The proportion of CRCBSI due to Candida 
      parapsilosis reached 33.3%, more than that of Candida albicans (28.6%). In 
      univariate analyses, older age (P=0.028) and lower body weight (P=0.037) were 
      associated with CRCBSI. Multivariate analysis showed that the sequential organ 
      failure assessment (SOFA) score was independently associated with CRCBSI (odds 
      ratio (OR)=1.142, 95% confidence interval = 1.049-1.244, P=0.002). Catheter 
      removal and immune enhancement therapy were often used for CRCBSI treatment. 
      CONCLUSIONS: In China, CRCBSI was more likely to occur in old patients with low 
      body weight. SOFA score was independently associated with CRCBSI. Candida 
      parapsilosis accounted for a high proportion of CRCBSI, but the difference from 
      non-CRCBSI was not significant.
FAU - Hu, Bo
AU  - Hu B
FAU - Du, Zhaohui
AU  - Du Z
FAU - Kang, Yan
AU  - Kang Y
FAU - Zang, Bin
AU  - Zang B
FAU - Cui, Wei
AU  - Cui W
FAU - Qin, Bingyu
AU  - Qin B
FAU - Fang, Qiang
AU  - Fang Q
FAU - Qiu, Haibo
AU  - Qiu H
FAU - Li, Jianguo
AU  - Li J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141113
PL  - England
TA  - BMC Infect Dis
JT  - BMC infectious diseases
JID - 100968551
RN  - 0 (Antifungal Agents)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Antifungal Agents/therapeutic use
MH  - Candida/*isolation & purification
MH  - Candida albicans/isolation & purification
MH  - Candidemia/drug therapy/*epidemiology/microbiology
MH  - Candidiasis/drug therapy/*epidemiology/microbiology
MH  - Catheter-Related Infections/drug therapy/*epidemiology/microbiology
MH  - China/epidemiology
MH  - *Cross Infection
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Intensive Care Units
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Risk Factors
PMC - PMC4234860
EDAT- 2014/11/14 06:00
MHDA- 2015/09/25 06:00
PMCR- 2014/11/13
CRDT- 2014/11/14 06:00
PHST- 2014/05/19 00:00 [received]
PHST- 2014/10/28 00:00 [accepted]
PHST- 2014/11/14 06:00 [entrez]
PHST- 2014/11/14 06:00 [pubmed]
PHST- 2015/09/25 06:00 [medline]
PHST- 2014/11/13 00:00 [pmc-release]
AID - s12879-014-0594-0 [pii]
AID - 594 [pii]
AID - 10.1186/s12879-014-0594-0 [doi]
PST - epublish
SO  - BMC Infect Dis. 2014 Nov 13;14:594. doi: 10.1186/s12879-014-0594-0.