PMID- 25392079
OWN - NLM
STAT- MEDLINE
DCOM- 20160308
LR  - 20220410
IS  - 1708-0428 (Electronic)
IS  - 0960-8923 (Print)
IS  - 0960-8923 (Linking)
VI  - 25
IP  - 8
DP  - 2015 Aug
TI  - Effect of Laparoscopic Roux-en-Y Gastric Bypass Surgery on Obstructive Sleep 
      Apnea in a Chinese Population with Obesity and T2DM.
PG  - 1446-53
LID - 10.1007/s11695-014-1510-9 [doi]
AB  - BACKGROUND: Bariatric surgery has been reported to be an effective treatment for 
      obstructive sleep apnea (OSA). However, this evidence was not enough for 
      different populations. Thus, we conducted a follow-up study to evaluate the 
      effect of bariatric surgery on OSA in a Chinese population with obesity and type 
      2 diabetes mellitus (T2DM). METHODS: From May 2011 to March 2014, 72 consecutive 
      subjects with obesity and T2DM were recruited for this study. Before and at least 
      6 months after the laparoscopic Roux-en-Y gastric bypass (LYGB) surgery, all 
      subjects were asked to undergo a polysomnography test. During the sleep center 
      visit, anthropometric characteristic data, blood samples, and sleep 
      questionnaires were collected. RESULTS: In total, 44 Chinese participants with 
      OSA were included in the study. Compared with baseline data, the postoperative 
      anthropometric characteristics, blood measurements, and sleep recording data, 
      such as weight, apnea hypopnea index (AHI), and insulin resistance index, 
      differed significantly (p < 0.001). The change in AHI was correlated 
      significantly with preoperative weight (r = 0.298, p < 0.05), preoperative AHI 
      (r = 0.729, p < 0.001), preoperative waist circumference (r = 0.307, p < 0.05), 
      and preoperative insulin resistance (IR) index (r = -0.301, p < 0.05). 
      Postoperative AHI was correlated significantly with age (r = 0.039, p = 0.039) 
      and preoperative AHI (r = 0.445, p = 0.002), and the following prediction model 
      was generated: log10 (postoperative AHI) = 0.626 x log10 (preoperative AHI) 
      +0.010 x age -0.581. CONCLUSIONS: Our findings indicate that LYGB could be an 
      effective therapeutic intervention in the management of OSA for patients with 
      both obesity and T2DM, and the preoperative AHI and age might be important 
      factors that influence the effort of LYGB.
FAU - Zou, Jianyin
AU  - Zou J
AD  - Department of Otolaryngology, Shanghai Jiao Tong University Affiliated Sixth 
      People's Hospital, Otolaryngology Institute of Shanghai Jiao Tong University, 600 
      Yishan Road, Shanghai, 200233, China.
FAU - Zhang, Pin
AU  - Zhang P
FAU - Yu, Haoyong
AU  - Yu H
FAU - Di, Jianzhong
AU  - Di J
FAU - Han, Xiaodong
AU  - Han X
FAU - Yin, Shankai
AU  - Yin S
FAU - Yi, Hongliang
AU  - Yi H
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Obes Surg
JT  - Obesity surgery
JID - 9106714
SB  - IM
MH  - Adult
MH  - Aged
MH  - Body Mass Index
MH  - China/epidemiology
MH  - Diabetes Mellitus, Type 2/complications/epidemiology/*surgery
MH  - Female
MH  - Follow-Up Studies
MH  - *Gastric Bypass/methods
MH  - Humans
MH  - Insulin Resistance
MH  - Laparoscopy/methods
MH  - Male
MH  - Middle Aged
MH  - Obesity/complications/epidemiology/*surgery
MH  - Polysomnography
MH  - Sleep/physiology
MH  - Sleep Apnea, Obstructive/complications/epidemiology/*surgery
MH  - Surveys and Questionnaires
MH  - Treatment Outcome
MH  - Young Adult
PMC - PMC4498416
COIS- The authors have no conflicts of interest to declare.
EDAT- 2014/11/14 06:00
MHDA- 2016/03/10 06:00
PMCR- 2014/11/14
CRDT- 2014/11/14 06:00
PHST- 2014/11/14 06:00 [entrez]
PHST- 2014/11/14 06:00 [pubmed]
PHST- 2016/03/10 06:00 [medline]
PHST- 2014/11/14 00:00 [pmc-release]
AID - 1510 [pii]
AID - 10.1007/s11695-014-1510-9 [doi]
PST - ppublish
SO  - Obes Surg. 2015 Aug;25(8):1446-53. doi: 10.1007/s11695-014-1510-9.