PMID- 25393773 OWN - NLM STAT- MEDLINE DCOM- 20161230 LR - 20191210 IS - 1475-097X (Electronic) IS - 1475-0961 (Linking) VI - 36 IP - 3 DP - 2016 May TI - The diagnostic performance of cardiac magnetic resonance in detection of myocardial involvement in AL amyloidosis. PG - 218-24 LID - 10.1111/cpf.12216 [doi] AB - BACKGROUND: The non-invasive assessment of amyloid heart disease may be challenging. Cardiac magnetic resonance (CMR) represents a method of choice for assessment of left ventricular (LV) morphology and function, and it also provides a unique possibility to evaluate the presence of amyloid deposition by the late gadolinium enhancement (LGE) technique. However, so far, published studies have not been consistent in terms of described LGE patterns associated with amyloid cardiomyopathy. AIMS: To compare echocardiographic and CMR assessment of LV morphology and function and to evaluate the presence and pattern of LGE in a population of patients with AL amyloid cardiomyopathy. METHODS: Twenty-two consecutive patients with newly diagnosed AL amyloid cardiomyopathy and without contraindications to CMR were comprehensively examined by echocardiography and CMR. RESULTS: Echocardiography and CMR did not differ in the evaluation of interventricular septal thickness, LV end-diastolic diameter and ejection fraction. Significant differences were found between echocardiographic and CMR estimates of LV end-diastolic volume (P<0.01) and LV mass (P<0.001). Various global LGE patterns (transmural homogenous or heterogeneous, subendocardial) were present in 17 patients (77%), patchy LGE was observed in one case (4.5%) and suboptimal nulling of the myocardium was reported in two subjects (9%). CONCLUSIONS: Echocardiography significantly overestimates LV mass and underestimates LV volumes in patients with AL amyloid cardiomyopathy as compared to CMR. As it is present in more than three quarters of individuals with AL amyloid cardiomyopathy, any type of global LGE pattern may be considered as pathogenomic for amyloid heart disease. CI - (c) 2014 Scandinavian Society of Clinical Physiology and Nuclear Medicine. Published by John Wiley & Sons Ltd. FAU - Fikrle, Michal AU - Fikrle M AD - 2nd Department of Medicine, Department of Cardiovascular Medicine, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague, Czech Republic. FAU - Palecek, Tomas AU - Palecek T AD - 2nd Department of Medicine, Department of Cardiovascular Medicine, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague, Czech Republic. AD - International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic. FAU - Masek, Martin AU - Masek M AD - Department of Radiology, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague, Czech Republic. FAU - Kuchynka, Petr AU - Kuchynka P AD - 2nd Department of Medicine, Department of Cardiovascular Medicine, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague, Czech Republic. AD - International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic. FAU - Straub, Jan AU - Straub J AD - 1st Department of Medicine, Department of Hematology, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague, Czech Republic. FAU - Spicka, Ivan AU - Spicka I AD - 1st Department of Medicine, Department of Hematology, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague, Czech Republic. FAU - Rysava, Romana AU - Rysava R AD - Department of Nephrology, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague, Czech Republic. FAU - Linhart, Ales AU - Linhart A AD - 2nd Department of Medicine, Department of Cardiovascular Medicine, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague, Czech Republic. LA - eng PT - Comparative Study PT - Evaluation Study PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20141113 PL - England TA - Clin Physiol Funct Imaging JT - Clinical physiology and functional imaging JID - 101137604 SB - IM MH - Aged MH - Amyloidosis/complications/*diagnostic imaging MH - Cardiomyopathies/complications/*diagnostic imaging MH - *Echocardiography MH - Female MH - Humans MH - Magnetic Resonance Imaging, Cine/*methods MH - Male MH - Reproducibility of Results MH - Sensitivity and Specificity MH - Ventricular Dysfunction, Left/*diagnostic imaging/etiology OTO - NOTNLM OT - AL amyloidosis OT - cardiac magnetic resonance OT - cardiomyopathy OT - echocardiography OT - late gadolinium enhancement EDAT- 2014/11/14 06:00 MHDA- 2016/12/31 06:00 CRDT- 2014/11/14 06:00 PHST- 2014/01/24 00:00 [received] PHST- 2014/10/21 00:00 [accepted] PHST- 2014/11/14 06:00 [entrez] PHST- 2014/11/14 06:00 [pubmed] PHST- 2016/12/31 06:00 [medline] AID - 10.1111/cpf.12216 [doi] PST - ppublish SO - Clin Physiol Funct Imaging. 2016 May;36(3):218-24. doi: 10.1111/cpf.12216. Epub 2014 Nov 13.