PMID- 25394658
OWN - NLM
STAT- MEDLINE
DCOM- 20150409
LR  - 20150216
IS  - 1522-1547 (Electronic)
IS  - 0193-1857 (Linking)
VI  - 308
IP  - 4
DP  - 2015 Feb 15
TI  - Estradiol decreases taurine level by reducing cysteine sulfinic acid 
      decarboxylase via the estrogen receptor-alpha in female mice liver.
PG  - G277-86
LID - 10.1152/ajpgi.00107.2014 [doi]
AB  - Cysteine sulfinic acid decarboxylase (CSAD) and cysteine dioxygenase (CDO) are 
      two rate-limiting enzymes in taurine de novo synthesis, and their expressions are 
      associated with estrogen concentration. The present study was designed to 
      determine the relationship between 17beta-estradiol (E(2)) and taurine in female mice 
      liver. We initially observed the mice had lower levels of CSAD, CDO, and taurine 
      during estrus than diestrus. We then, respectively, treated the ovariectomized 
      mice, the cultured hepatocytes, and Hep G2 cells with different doses of E(2), and 
      the CSAD and CDO expressions and taurine levels were analyzed. The results showed 
      that E(2) decreased taurine level in the serum and the cultured cells by inhibiting 
      CSAD and CDO expressions. Furthermore, we identified the molecular receptor types 
      through which E(2) plays its role in regulating taurine synthesis, and our results 
      showed that estrogen receptor-alpha (ERalpha) expression was much higher than estrogen 
      receptor-beta (ERbeta) in the liver and hepatocytes, and the inhibiting effects of E(2) 
      on CSAD, CDO, and taurine level were partially abrogated in the 
      ICI-182,780-pretreated liver and hepatocytes, and in ERalpha knockout mice. These 
      results indicate that estradiol decreases taurine content by reducing taurine 
      biosynthetic enzyme expression in mice liver.
CI  - Copyright (c) 2015 the American Physiological Society.
FAU - Ma, Qiwang
AU  - Ma Q
AD  - State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China 
      Agricultural University, Beijing, People's Republic of China.
FAU - Zhao, Jianjun
AU  - Zhao J
AD  - State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China 
      Agricultural University, Beijing, People's Republic of China.
FAU - Cao, Wei
AU  - Cao W
AD  - State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China 
      Agricultural University, Beijing, People's Republic of China.
FAU - Liu, Jiali
AU  - Liu J
AD  - State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China 
      Agricultural University, Beijing, People's Republic of China.
FAU - Cui, Sheng
AU  - Cui S
AD  - State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China 
      Agricultural University, Beijing, People's Republic of China cuisheng@cau.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141113
PL  - United States
TA  - Am J Physiol Gastrointest Liver Physiol
JT  - American journal of physiology. Gastrointestinal and liver physiology
JID - 100901227
RN  - 0 (Estrogen Receptor Antagonists)
RN  - 0 (Estrogen Receptor alpha)
RN  - 0 (Estrogens)
RN  - 0 (RNA, Messenger)
RN  - 1EQV5MLY3D (Taurine)
RN  - 4TI98Z838E (Estradiol)
RN  - EC 1.13.11.20 (Cysteine Dioxygenase)
RN  - EC 4.1.1.- (Carboxy-Lyases)
RN  - EC 4.1.1.29 (sulfoalanine decarboxylase)
SB  - IM
MH  - Animals
MH  - Carboxy-Lyases/genetics/*metabolism
MH  - Cysteine Dioxygenase/genetics/metabolism
MH  - Diestrus/blood
MH  - Dose-Response Relationship, Drug
MH  - Down-Regulation
MH  - Estradiol/*pharmacology
MH  - Estrogen Receptor Antagonists/pharmacology
MH  - Estrogen Receptor alpha/*agonists/deficiency/genetics/metabolism
MH  - *Estrogen Replacement Therapy
MH  - Estrogens/*pharmacology
MH  - Estrus/blood
MH  - Female
MH  - HEK293 Cells
MH  - Hep G2 Cells
MH  - Hepatocytes/*drug effects/enzymology
MH  - Humans
MH  - Liver/*drug effects/enzymology
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Ovariectomy
MH  - RNA, Messenger/metabolism
MH  - Signal Transduction/drug effects
MH  - Taurine/*blood
OTO - NOTNLM
OT  - cysteine dioxygenase
EDAT- 2014/11/15 06:00
MHDA- 2015/04/10 06:00
CRDT- 2014/11/15 06:00
PHST- 2014/11/15 06:00 [entrez]
PHST- 2014/11/15 06:00 [pubmed]
PHST- 2015/04/10 06:00 [medline]
AID - ajpgi.00107.2014 [pii]
AID - 10.1152/ajpgi.00107.2014 [doi]
PST - ppublish
SO  - Am J Physiol Gastrointest Liver Physiol. 2015 Feb 15;308(4):G277-86. doi: 
      10.1152/ajpgi.00107.2014. Epub 2014 Nov 13.