PMID- 25394967
OWN - NLM
STAT- MEDLINE
DCOM- 20150826
LR  - 20181113
IS  - 1432-1963 (Electronic)
IS  - 0172-8113 (Linking)
VI  - 35 Suppl 2
DP  - 2014 Nov
TI  - [Value of core needle biopsy in preoperative diagnostics of soft tissue tumors: 
      possibilities and limitations].
PG  - 189-97
LID - 10.1007/s00292-014-2010-3 [doi]
AB  - The differential diagnosis of soft tissue swellings encompasses a variety of 
      benign, intermediate, low-grade malignant and high-grade neoplastic lesions in 
      addition to tumor-like reactive processes. As treatment of these heterogeneous 
      conditions varies greatly from conservative observation and simple local excision 
      up to extensive radical surgical resection, treatment decisions are based mainly 
      on a precise preoperative histological diagnosis on limited biopsy material. Even 
      for clinically unequivocal sarcomas, the importance of the preoperative 
      histological diagnosis has been increasingly emphasized as different therapeutic 
      regimens have been established for different sarcoma types and the indications 
      for preoperative treatment is influenced by the tumor grade and by the entity 
      itself. Other factors positively influencing the increasing use of core needle 
      biopsy for preoperative tumor diagnosis in soft tissue pathology are the 
      availability of modern high-resolution imaging modalities as well as the 
      establishment of several new second generation immunohistochemical markers and 
      the discovery of entity-specific translocations detected by fluorescence in situ 
      hybridization (FISH) in several sarcoma subtypes. In this review it will be shown 
      that a targeted approach for processing core needle biopsies oriented towards the 
      characteristic topographical, demographic, cytomorphological and architectural 
      features of soft tissue lesions facilitates a precise diagnosis of soft tissue 
      neoplasms in most cases. However, profound knowledge of the different aspects of 
      soft tissue tumor diagnostics and familiarity with the frequent as well as the 
      less common and rare tumor entities and variants is a prerequisite for 
      appropriate interpretation of core needle biopsy findings and for selecting a 
      limited but well-suited marker panel. The utilization of modern 
      immunohistochemistry and/or FISH methods is highly useful for establishing the 
      diagnosis of rare and unusual neoplasms in core needle biopsies.
FAU - Agaimy, A
AU  - Agaimy A
AD  - Pathologisches Institut, Universitatsklinikum Erlangen, Krrankenhausstr. 8-10, 
      91054, Erlangen, Deutschland, abbas.agaimy@uk-erlangen.de.
LA  - ger
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Stellenwert der Stanzbiopsie in der praoperativen Diagnostik von Weichteiltumoren 
      : Moglichkeiten und Grenzen.
PL  - Germany
TA  - Pathologe
JT  - Der Pathologe
JID - 8006541
RN  - 0 (Biomarkers, Tumor)
SB  - IM
MH  - Biomarkers, Tumor/analysis/genetics
MH  - Biopsy, Large-Core Needle
MH  - Connective Tissue/pathology
MH  - Diagnosis, Differential
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Preoperative Care
MH  - Soft Tissue Neoplasms/classification/genetics/*pathology/*surgery
EDAT- 2014/11/15 06:00
MHDA- 2015/08/27 06:00
CRDT- 2014/11/15 06:00
PHST- 2014/11/15 06:00 [entrez]
PHST- 2014/11/15 06:00 [pubmed]
PHST- 2015/08/27 06:00 [medline]
AID - 10.1007/s00292-014-2010-3 [doi]
PST - ppublish
SO  - Pathologe. 2014 Nov;35 Suppl 2:189-97. doi: 10.1007/s00292-014-2010-3.