PMID- 25395853
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20141114
LR  - 20220419
IS  - 1176-6328 (Print)
IS  - 1178-2021 (Electronic)
IS  - 1176-6328 (Linking)
VI  - 10
DP  - 2014
TI  - Spinal cord demyelination combined with hyperhomocysteinemia: a case report.
PG  - 2057-9
LID - 10.2147/NDT.S70963 [doi]
AB  - Hyperhomocysteinemia (HHcy) has been recognized as an independent risk factor for 
      atherosclerotic vascular disease. Here we report a patient who suffered from 
      spinal cord demyelination combined with HHcy. The patient was admitted to our 
      hospital with a diagnosis of acute myelitis. However, hormone therapy was 
      ineffective. Further investigations revealed that he had HHcy and a homozygous 
      mutation of the gene encoding methylenetetrahydrofolate reductase (MTHFR) 
      c.677C>T, which is a key enzyme involved in homocysteine metabolism. In view of 
      these findings, we treated the patient with B vitamins and his symptoms gradually 
      improved. Spinal magnetic resonance imaging performed 3 months after onset showed 
      near recovery of the lesion. To our knowledge, similar reports are rare.
FAU - Hao, Meimei
AU  - Hao M
AD  - Department of Neurology, Xijing Hospital, Fourth Military Medical University, 
      Xi'an, People's Republic of China.
FAU - Zhang, Yan
AU  - Zhang Y
AD  - Department of Neurology, Xijing Hospital, Fourth Military Medical University, 
      Xi'an, People's Republic of China.
FAU - Hou, Shuangxing
AU  - Hou S
AD  - Department of Neurology, Xijing Hospital, Fourth Military Medical University, 
      Xi'an, People's Republic of China.
FAU - Chen, Yanling
AU  - Chen Y
AD  - Department of Neurology, Xijing Hospital, Fourth Military Medical University, 
      Xi'an, People's Republic of China.
FAU - Shi, Ming
AU  - Shi M
AD  - Department of Neurology, Xijing Hospital, Fourth Military Medical University, 
      Xi'an, People's Republic of China.
FAU - Zhao, Gang
AU  - Zhao G
AD  - Department of Neurology, Xijing Hospital, Fourth Military Medical University, 
      Xi'an, People's Republic of China.
FAU - Deng, Yanchun
AU  - Deng Y
AD  - Department of Neurology, Xijing Hospital, Fourth Military Medical University, 
      Xi'an, People's Republic of China.
LA  - eng
PT  - Case Reports
DEP - 20141103
PL  - New Zealand
TA  - Neuropsychiatr Dis Treat
JT  - Neuropsychiatric disease and treatment
JID - 101240304
PMC - PMC4224091
OTO - NOTNLM
OT  - demyelination
OT  - homocysteine
OT  - hyperhomocysteinemia
OT  - methylation
OT  - methylenetetrahydrofolate reductase
EDAT- 2014/11/15 06:00
MHDA- 2014/11/15 06:01
PMCR- 2014/11/03
CRDT- 2014/11/15 06:00
PHST- 2014/11/15 06:00 [entrez]
PHST- 2014/11/15 06:00 [pubmed]
PHST- 2014/11/15 06:01 [medline]
PHST- 2014/11/03 00:00 [pmc-release]
AID - ndt-10-2057 [pii]
AID - 10.2147/NDT.S70963 [doi]
PST - epublish
SO  - Neuropsychiatr Dis Treat. 2014 Nov 3;10:2057-9. doi: 10.2147/NDT.S70963. 
      eCollection 2014.