PMID- 25395978 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20141114 LR - 20200930 IS - 1738-3684 (Print) IS - 1976-3026 (Electronic) IS - 1738-3684 (Linking) VI - 11 IP - 4 DP - 2014 Oct TI - The effectiveness of cross-tapering switching to ziprasidone in patients with schizophrenia or schizoaffective disorder. PG - 459-66 LID - 10.4306/pi.2014.11.4.459 [doi] AB - OBJECTIVE: Switching antipsychotics is one useful therapeutic option when the treatment of schizophrenia encounters suboptimal efficacy and intolerability issues. This study aimed to investigate the efficacy and tolerability of cross-tapering switching to ziprasidone from other antipsychotics. METHODS: A total of 67 patients with schizophrenia or schizoaffective disorder were recruited in this 12-week, multicenter, non-comparative, open-label trial. Prior antipsychotics were allowed to be maintained for up to 4 weeks during the titration of ziprasidone. Efficacy was primarily measured using the 18-item Brief Psychotic Rating Scale (BPRS) at baseline, 4 weeks, 8 weeks, and 12 weeks. Efficacy was secondarily measured by the Clinical Global Impression-Severity (CGI-S) scale and the Global Assessment of Functioning (GAF) scale at each visit. Regarding the metabolic effects of switching to ziprasidone, weight, body mass index (BMI), waist-to-hip ratio (WHR), and lipid profile-including triglyceride (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL), and total cholesterol levels-were measured at each follow-up visit. RESULTS: The BPRS scores were significantly improved at 12 weeks after switching to ziprasidone (F=5.96, df=2.11, p=0.003), whereas the CGI-S and GAF scores were not significantly changed. BMIs, WHRs, and TG levels were significantly decreased, with no significant changes in other lipid profiles. CONCLUSION: Cross-tapering switching to ziprasidone is effective for patients with schizophrenia spectrum disorders. Beyond the efficacy of the procedure, favorable metabolic profiles show that switching to ziprasidone may be helpful for maintenance therapy over an extended period. FAU - Ko, Young-Hoon AU - Ko YH AD - Department of Psychiatry, Korea University College of Medicine, Ansan Hospital, Ansan, Republic of Korea. FAU - Na, Kyoung-Sae AU - Na KS AD - Department of Psychiatry, Gachon University Gil Medical Center, Incheon, Republic of Korea. FAU - Kim, Chul-Eung AU - Kim CE AD - Department of Psychiatry, Inha University Hospital, Incheon, Republic of Korea. FAU - Kim, Seung-Hyun AU - Kim SH AD - Department of Psychiatry, Korea University College of Medicine, Guro Hospital, Seoul, Republic of Korea. FAU - Jeon, Yang-Whan AU - Jeon YW AD - Department of Psychiatry, Incheon St. Mary's Hospital, The Catholic University of Korea College of Korea, Incheon, Republic of Korea. FAU - Yi, Jung-Seo AU - Yi JS AD - Department of Psychiatry, Hallym University College of Medicine, Kangnam Sacred Heart Hospital, Seoul, Republic of Korea. FAU - Lee, Moon-Soo AU - Lee MS AD - Department of Psychiatry, Incheon St. Mary's Hospital, The Catholic University of Korea College of Korea, Incheon, Republic of Korea. FAU - Kim, Shin-Gyeom AU - Kim SG AD - Department of Psychiatry, Soonchunhyang University College of Medicine, Bucheon Hospital, Bucheon, Republic of Korea. FAU - Jeong, Hyun-Ghang AU - Jeong HG AD - Department of Psychiatry, Incheon St. Mary's Hospital, The Catholic University of Korea College of Korea, Incheon, Republic of Korea. FAU - Jung, Han-Yong AU - Jung HY AD - Department of Psychiatry, Soonchunhyang University College of Medicine, Bucheon Hospital, Bucheon, Republic of Korea. LA - eng PT - Journal Article DEP - 20141020 PL - Korea (South) TA - Psychiatry Investig JT - Psychiatry investigation JID - 101242994 PMC - PMC4225211 OTO - NOTNLM OT - Pharmacotherapy OT - Schizophrenia OT - Switching OT - Triglyceride OT - Ziprasidone EDAT- 2014/11/15 06:00 MHDA- 2014/11/15 06:01 PMCR- 2014/10/01 CRDT- 2014/11/15 06:00 PHST- 2014/01/27 00:00 [received] PHST- 2014/05/04 00:00 [revised] PHST- 2014/05/14 00:00 [accepted] PHST- 2014/11/15 06:00 [entrez] PHST- 2014/11/15 06:00 [pubmed] PHST- 2014/11/15 06:01 [medline] PHST- 2014/10/01 00:00 [pmc-release] AID - 10.4306/pi.2014.11.4.459 [doi] PST - ppublish SO - Psychiatry Investig. 2014 Oct;11(4):459-66. doi: 10.4306/pi.2014.11.4.459. Epub 2014 Oct 20.