PMID- 25396334
OWN - NLM
STAT- MEDLINE
DCOM- 20150126
LR  - 20220321
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 93
IP  - 22
DP  - 2014 Nov
TI  - High-pitch coronary CT angiography at 70 kVp with low contrast medium volume: 
      comparison of 80 and 100 kVp high-pitch protocols.
PG  - e92
LID - 10.1097/MD.0000000000000092 [doi]
LID - e92
AB  - The purpose of this article is to evaluate image quality and radiation dose of 
      prospectively electrocardiogram (ECG)-triggered high-pitch coronary computed 
      tomography angiography (CCTA) at 70 kVp and 30 mL contrast medium.One hundred 
      fifty patients with a heart rate </=70 beats per minute (bpm) underwent CCTA using 
      a second-generation dual-source computed tomography (CT) scanner and were 
      randomized into 3 groups according to tube voltage and contrast medium volume 
      (370 mg/mL iodine concentration) (100 kVp group, 100 kVp/60 mL, n = 55; 80 kVp 
      group, 80 kVp/60 mL, n = 44; 70 kVp group, 70 kVp/30 mL, n = 51). Objective and 
      subjective image quality along with the effect of heart rate (HR) and body mass 
      index (BMI) was evaluated and compared between the groups. Radiation dose was 
      estimated for each patient.CT attenuation and image noise were higher in the 80 
      and 70 kVp groups than in the 100 kVp group (all P < 0.001). Signal-to-noise 
      ratios (SNRs) and contrast-to-noise ratios (CNRs) were lower in the 70 kVp group 
      than in the 80 and 100 kVp groups (all P < 0.05). There was no difference for 
      subjective image quality between the groups (P > 0.05). HR did not affect 
      subjective image quality (all P > 0.05), while patients with BMI <23 kg/m had 
      higher image quality than patients with BMI >/=23 kg/m (P < 0.05). Compared with 
      the 100 kVp group, the radiation dose of the 70 kVp group was reduced by 75%.In 
      conclusion, prospectively ECG-triggered high-pitch 70 kVp/30 mL CCTA can obtain 
      diagnostic image quality with lower radiation dose in selected patients with BMI 
      <23 kg/m compared with 80/100 kVp/60 mL CCTA.
FAU - Zhang, Long Jiang
AU  - Zhang LJ
AD  - Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing 
      University, Nanjing, China.
FAU - Qi, Li
AU  - Qi L
FAU - De Cecco, Carlo N
AU  - De Cecco CN
FAU - Zhou, Chang Sheng
AU  - Zhou CS
FAU - Spearman, James V
AU  - Spearman JV
FAU - Schoepf, U Joseph
AU  - Schoepf UJ
FAU - Lu, Guang Ming
AU  - Lu GM
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Contrast Media)
SB  - IM
MH  - Contrast Media/*administration & dosage
MH  - Coronary Angiography/*methods
MH  - Electrocardiography/*methods
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Radiation Dosage
MH  - Tomography, X-Ray Computed/*methods
PMC - PMC4616317
COIS- The authors have no funding and conflicts of interest to disclose.
EDAT- 2014/11/15 06:00
MHDA- 2015/01/27 06:00
PMCR- 2014/11/07
CRDT- 2014/11/15 06:00
PHST- 2014/11/15 06:00 [entrez]
PHST- 2014/11/15 06:00 [pubmed]
PHST- 2015/01/27 06:00 [medline]
PHST- 2014/11/07 00:00 [pmc-release]
AID - 00005792-201411020-00001 [pii]
AID - 10.1097/MD.0000000000000092 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2014 Nov;93(22):e92. doi: 10.1097/MD.0000000000000092.