PMID- 25398321 OWN - NLM STAT- MEDLINE DCOM- 20150330 LR - 20181113 IS - 1750-1326 (Electronic) IS - 1750-1326 (Linking) VI - 9 DP - 2014 Nov 15 TI - Increase of angiotensin II type 1 receptor auto-antibodies in Huntington's disease. PG - 49 LID - 10.1186/1750-1326-9-49 [doi] LID - 49 AB - BACKGROUND: In the recent years, a role of the immune system in Huntington's disease (HD) is increasingly recognized. Here we investigate the presence of T cell activating auto-antibodies against angiotensin II type 1 receptors (AT1R) in all stages of the disease as compared to healthy controls and patients suffering from multiple sclerosis (MS) as a prototype neurologic autoimmune disease. RESULTS: As compared to controls, MS patients show higher titers of anti-AT1R antibodies, especially in individuals with active disease. In HD, anti-AT1R antibodies are more frequent than in healthy controls or even MS and occur in 37.9% of patients with relevant titers >/= 20 U/ml. In a correlation analysis with clinical parameters, the presence of AT1R antibodies in the sera of HD individuals inversely correlated with the age of onset and positively with the disease burden score as well as with smoking and infection. CONCLUSIONS: These data suggest a dysfunction of the adaptive immune system in HD which may be triggered by different stimuli including autoimmune responses, infection and possibly also smoking. FAU - Lee, De-Hyung AU - Lee DH FAU - Heidecke, Harald AU - Heidecke H FAU - Schroder, Alexandra AU - Schroder A FAU - Paul, Friedemann AU - Paul F FAU - Wachter, Rolf AU - Wachter R FAU - Hoffmann, Rainer AU - Hoffmann R FAU - Ellrichmann, Gisa AU - Ellrichmann G FAU - Dragun, Duska AU - Dragun D FAU - Waschbisch, Anne AU - Waschbisch A FAU - Stegbauer, Johannes AU - Stegbauer J FAU - Klotz, Peter AU - Klotz P FAU - Gold, Ralf AU - Gold R FAU - Dechend, Ralf AU - Dechend R FAU - Muller, Dominik N AU - Muller DN FAU - Saft, Carsten AU - Saft C AD - Department of Neurology, Friedrich Alexander University Erlangen-Nurnberg, Schwabachanlage 6, Erlangen 91054, Germany. carsten.saft@rub.de. FAU - Linker, Ralf A AU - Linker RA LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20141115 PL - England TA - Mol Neurodegener JT - Molecular neurodegeneration JID - 101266600 RN - 0 (Autoantibodies) RN - 0 (Autoantigens) RN - 0 (Receptor, Angiotensin, Type 1) SB - IM MH - Adult MH - Aged MH - Aged, 80 and over MH - Autoantibodies/*immunology MH - Autoantigens/immunology MH - Enzyme-Linked Immunosorbent Assay MH - Female MH - Humans MH - Huntington Disease/*immunology MH - Male MH - Middle Aged MH - Receptor, Angiotensin, Type 1/*immunology MH - Young Adult PMC - PMC4246494 EDAT- 2014/11/16 06:00 MHDA- 2015/03/31 06:00 PMCR- 2014/11/15 CRDT- 2014/11/16 06:00 PHST- 2014/05/04 00:00 [received] PHST- 2014/09/19 00:00 [accepted] PHST- 2014/11/16 06:00 [entrez] PHST- 2014/11/16 06:00 [pubmed] PHST- 2015/03/31 06:00 [medline] PHST- 2014/11/15 00:00 [pmc-release] AID - #N/A [pii] AID - 558 [pii] AID - 10.1186/1750-1326-9-49 [doi] PST - epublish SO - Mol Neurodegener. 2014 Nov 15;9:49. doi: 10.1186/1750-1326-9-49.