PMID- 25398499 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20160201 LR - 20150422 IS - 1752-8976 (Electronic) IS - 1470-3203 (Linking) VI - 16 IP - 1 DP - 2015 Mar TI - Retracted: Association of ACE I/D gene polymorphism with T2DN susceptibility and the risk of T2DM developing into T2DN in a Caucasian population. PG - 165-71 LID - 10.1177/1470320314557849 [doi] AB - BACKGROUND AND OBJECTIVE: The association of the angiotensin-converting enzyme (ACE) insertion/deletion (I/D) gene polymorphism with type-2 diabetic nephropathy (T2DN) susceptibility and the risk of type-2 diabetes mellitus (T2DM) developing into T2DN in Caucasian populations is still controversial. A meta-analysis was performed to evaluate the association of ACE I/D gene polymorphism with T2DN susceptibility and the risk of T2DM developing into T2DN in Caucasian populations. METHOD: A predefined literature search and selection of eligible relevant studies were performed to collect data from electronic databases. RESULTS: Sixteen articles were identified for the analysis of the association of ACE I/D gene polymorphism with T2DN susceptibility and the risk of T2DM developing into T2DN in Caucasian populations. ACE I/D gene polymorphism was not associated with T2DN susceptibility and the risk of patients with T2DM developing T2DN in Caucasian populations. Sensitivity analysis according to sample size of case (<100 vs. >/=100) was also performed, and the results were similar to the non-sensitivity analysis. CONCLUSIONS: ACE I/D gene polymorphism was not associated with T2DN susceptibility and the risk of patients with T2DM developing T2DN in Caucasian populations. However, more studies should be performed in the future. CI - (c) The Author(s) 2014. FAU - Liu, Guohui AU - Liu G AD - Department of Nephrology, Dong Guan Municipal People's Hospital, Dongguan, China. FAU - Zhou, Tian-Biao AU - Zhou TB AD - Department of Nephrology, the Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510655, China. FAU - Jiang, Zongpei AU - Jiang Z AD - Department of Nephrology, the Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510655, China zongpeijiang@yeah.net. FAU - Zheng, Dongwen AU - Zheng D AD - Department of Nephrology, Dong Guan Municipal People's Hospital, Dongguan, China. LA - eng PT - Journal Article PT - Retracted Publication DEP - 20141114 PL - England TA - J Renin Angiotensin Aldosterone Syst JT - Journal of the renin-angiotensin-aldosterone system : JRAAS JID - 100971636 RIN - J Renin Angiotensin Aldosterone Syst. 2015 Dec;16(4):NP10. PMID: 26699833 OTO - NOTNLM OT - Type-2 diabetic nephropathy (T2DN) OT - angiotensin-converting enzyme (ACE) OT - insertion/deletion (I/D) gene polymorphism OT - meta-analysis OT - type-2 diabetes mellitus (T2DM) EDAT- 2014/11/16 06:00 MHDA- 2014/11/16 06:01 CRDT- 2014/11/16 06:00 PHST- 2014/09/14 00:00 [received] PHST- 2014/09/28 00:00 [accepted] PHST- 2014/11/16 06:00 [entrez] PHST- 2014/11/16 06:00 [pubmed] PHST- 2014/11/16 06:01 [medline] AID - 1470320314557849 [pii] AID - 10.1177/1470320314557849 [doi] PST - ppublish SO - J Renin Angiotensin Aldosterone Syst. 2015 Mar;16(1):165-71. doi: 10.1177/1470320314557849. Epub 2014 Nov 14.