PMID- 25398690
OWN - NLM
STAT- MEDLINE
DCOM- 20150310
LR  - 20220324
IS  - 1423-0380 (Electronic)
IS  - 1010-4283 (Linking)
VI  - 35
IP  - 12
DP  - 2014 Dec
TI  - Effects of interleukin-18 promoter (C607A and G137C) gene polymorphisms and their 
      association with oral squamous cell carcinoma (OSCC) in northern India.
PG  - 12275-84
LID - 10.1007/s13277-014-2538-0 [doi]
AB  - Interleukin-18 (IL-18) is one of the immunomodulatory cytokines that plays an 
      important role in cellular functions against tumor development and progression. 
      IL-18 (-607) C/A and (-0137) G/C gene promoter polymorphisms and their haplotypes 
      variants are associated with risk of various cancers. We evaluated a possible 
      association of IL-18 (-607) C/A and (-137) G/C gene promoter polymorphisms in the 
      susceptibility to oral squamous cell carcinoma (OSCC). A total number of 272 
      patients with OSCC and 185 healthy volunteers were genotyped for the IL-18 (-607) 
      C/A and (-137) G/C polymorphism. Polymorphism variants were examined by using 
      tetra-primer amplification refractory mutation system (T-ARMS). Genotype 
      frequencies were evaluated by chi-square test and odds ratio (OR) relative risk. 
      IL-18 (-137) G/C gene polymorphism was significantly associated with the risk of 
      OSCC as compared to healthy volunteers (genotype GG vs GC: OR 2.238; 95 % CI 
      1.455-3.441; p = 0.0003 and allele G vs C: OR 1.984; 95 % CI 1.335-2.947; p = 
      0.0007). The genotype and allele frequencies of the IL-18 promoter -607 C/A 
      polymorphism in OSCC patients were not significantly different than that in 
      healthy controls (p > 0.05). Our results suggest that IL-18 -137 G/C polymorphism 
      is significantly associated with the progression of oral cancer but -607 C/A 
      polymorphism is not associated with this.
FAU - Singh, Prithvi Kumar
AU  - Singh PK
AD  - Department of Anaesthesiology, King George's Medical University, Lucknow, Uttar 
      Pradesh, 226003, India.
FAU - Ahmad, Mohd Kaleem
AU  - Ahmad MK
FAU - Kumar, Vijay
AU  - Kumar V
FAU - Hussain, Syed Rizwan
AU  - Hussain SR
FAU - Gupta, Rajni
AU  - Gupta R
FAU - Jain, Amita
AU  - Jain A
FAU - Mahdi, Abbas Ali
AU  - Mahdi AA
FAU - Bogra, Jaishri
AU  - Bogra J
FAU - Chandra, Girish
AU  - Chandra G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141115
PL  - Netherlands
TA  - Tumour Biol
JT  - Tumour biology : the journal of the International Society for Oncodevelopmental 
      Biology and Medicine
JID - 8409922
RN  - 0 (Interleukin-18)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Carcinoma, Squamous Cell/*genetics/pathology
MH  - Case-Control Studies
MH  - Environment
MH  - Female
MH  - Gene Frequency
MH  - Gene-Environment Interaction
MH  - Genetic Association Studies
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - India
MH  - Interleukin-18/*genetics
MH  - Male
MH  - Middle Aged
MH  - Mouth Neoplasms/*genetics/pathology
MH  - Neoplasm Grading
MH  - Neoplasm Metastasis
MH  - Neoplasm Staging
MH  - *Polymorphism, Single Nucleotide
MH  - *Promoter Regions, Genetic
MH  - Risk Factors
EDAT- 2014/11/16 06:00
MHDA- 2015/03/11 06:00
CRDT- 2014/11/16 06:00
PHST- 2014/06/11 00:00 [received]
PHST- 2014/08/20 00:00 [accepted]
PHST- 2014/11/16 06:00 [entrez]
PHST- 2014/11/16 06:00 [pubmed]
PHST- 2015/03/11 06:00 [medline]
AID - 10.1007/s13277-014-2538-0 [doi]
PST - ppublish
SO  - Tumour Biol. 2014 Dec;35(12):12275-84. doi: 10.1007/s13277-014-2538-0. Epub 2014 
      Nov 15.