PMID- 25399488
OWN - NLM
STAT- MEDLINE
DCOM- 20160201
LR  - 20220321
IS  - 1440-1843 (Electronic)
IS  - 1323-7799 (Linking)
VI  - 20
IP  - 2
DP  - 2015 Feb
TI  - Repeated inhalation of sevoflurane inhibits airway inflammation in an OVA-induced 
      mouse model of allergic airway inflammation.
PG  - 258-63
LID - 10.1111/resp.12439 [doi]
AB  - BACKGROUND AND OBJECTIVE: Repeated inhalation of sevoflurane (SVF) can benefit 
      asthmatic patients by bronchodilation. However, the impact of repeated inhalation 
      of SVF on allergic airway inflammation has not been clarified. This study was 
      aimed at investigating the effects of repeated inhalation of SVF on airway 
      inflammation in mice. METHODS: Female C57BL/6 mice were sensitized with ovalbumin 
      (OVA) and treated by inhalation with SVF or vehicle daily for seven consecutive 
      days, immediately followed by OVA challenge. Airway inflammation was evaluated by 
      counting the numbers of different types of inflammatory infiltrates in 
      bronchoalveolar lavage fluid (BALF), histology, cytokine measurements and mucus 
      production in individual mice. RESULTS: In comparison with the OVA group, 
      repeated inhalation of SVF significantly reduced the numbers of total cells, 
      eosinophils, lymphocytes, macrophages and neutrophils (P < 0.05 to P < 0.01), and 
      the levels of BALF tumour necrosis factor-alpha and lung high-mobility group box 1 (P 
      < 0.01), accompanied by elevated levels of BALF interleukin-10 in allergic mice 
      (P < 0.05). Repeat inhalation of SVF decreased the levels of serum OVA-specific 
      immunoglobulin E (IgE) and mitigated allergic airway epithelial goblet cell 
      hyperplasia and mucus hypersecretion in allergic mice (P < 0.01). CONCLUSIONS: 
      Repeated inhalation of SVF inhibits allergic airway inflammation by reducing 
      inflammatory infiltrates, improving the imbalance of cytokine responses and 
      mitigating allergen-specific IgE responses and goblet cell hyperplasia in mice.
CI  - (c) 2014 Asian Pacific Society of Respirology.
FAU - Shen, Qi-Ying
AU  - Shen QY
AD  - Department of Pulmonary, Anhui Geriatric Institute, The First Affiliated Hospital 
      of Anhui Medical University, Hefei, Anhui, China; Department of Anesthesiology, 
      The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
FAU - Fang, Lei
AU  - Fang L
FAU - Wu, Hui-Mei
AU  - Wu HM
FAU - He, Fang
AU  - He F
FAU - Ding, Pei-Shan
AU  - Ding PS
FAU - Liu, Rong-Yu
AU  - Liu RY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141117
PL  - Australia
TA  - Respirology
JT  - Respirology (Carlton, Vic.)
JID - 9616368
RN  - 0 (Bronchodilator Agents)
RN  - 0 (HMGB1 Protein)
RN  - 0 (Methyl Ethers)
RN  - 0 (TNF protein, human)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 130068-27-8 (Interleukin-10)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 38LVP0K73A (Sevoflurane)
RN  - 9006-59-1 (Ovalbumin)
SB  - IM
MH  - Animals
MH  - Asthma/blood/chemically induced/*drug therapy
MH  - Bronchoalveolar Lavage Fluid/chemistry/cytology
MH  - Bronchodilator Agents/*administration & dosage
MH  - Disease Models, Animal
MH  - Eosinophils
MH  - Female
MH  - Goblet Cells/*pathology
MH  - HMGB1 Protein/analysis
MH  - Hyperplasia/pathology
MH  - Immunoglobulin E/blood
MH  - Inflammation/chemically induced/drug therapy
MH  - Interleukin-10/analysis
MH  - Lung/*pathology
MH  - Lymphocyte Count
MH  - Macrophages
MH  - Methyl Ethers/*administration & dosage
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mucus/drug effects/metabolism
MH  - Neutrophils
MH  - Ovalbumin
MH  - Sevoflurane
MH  - Tumor Necrosis Factor-alpha/analysis
OTO - NOTNLM
OT  - allergen
OT  - high-mobility group box 1
OT  - inflammation
OT  - inhalational anaesthetic
OT  - sevoflurane
EDAT- 2014/11/18 06:00
MHDA- 2016/02/02 06:00
CRDT- 2014/11/18 06:00
PHST- 2014/06/16 00:00 [received]
PHST- 2014/08/31 00:00 [revised]
PHST- 2014/09/08 00:00 [revised]
PHST- 2014/09/15 00:00 [accepted]
PHST- 2014/11/18 06:00 [entrez]
PHST- 2014/11/18 06:00 [pubmed]
PHST- 2016/02/02 06:00 [medline]
AID - 10.1111/resp.12439 [doi]
PST - ppublish
SO  - Respirology. 2015 Feb;20(2):258-63. doi: 10.1111/resp.12439. Epub 2014 Nov 17.