PMID- 25399820
OWN - NLM
STAT- MEDLINE
DCOM- 20151125
LR  - 20181113
IS  - 1347-7439 (Electronic)
IS  - 0916-7250 (Print)
IS  - 0916-7250 (Linking)
VI  - 77
IP  - 2
DP  - 2015 Feb
TI  - Adjuvant effects of recombinant giant panda (Ailuropoda melanoleuca) IL-18 on the 
      canine distemper disease vaccine in mice.
PG  - 187-92
LID - 10.1292/jvms.14-0226 [doi]
AB  - Canine distemper virus (CDV) is a morbillivirus known to cause morbidity and 
      mortality in a broad range of animals. Giant pandas (Ailuropoda melanoleuca), 
      especially captive ones, are susceptible to natural infection with CDV. 
      Interleukin-18 (IL-18) is a powerful adjuvant molecule that can enhance the 
      development of antigen-specific immunity and vaccine efficacy. In this study, a 
      giant panda IL-18 gene eukaryotic expression plasmid (pcAmIL-18) was constructed. 
      Female BALB/c mice were muscularly inoculated with the plasmids pcAmIL-18, 
      pcDNA3.1 and PBS, respectively. They were subsequently injected with an 
      attenuated CDV vaccine for dogs, and the induced humoral and cellular responses 
      were evaluated. The results showed that pcAmIL-18 remarkably improved the level 
      of specific antibody, IFN-gamma and IL-2 in mice sera, the T lymphocyte proliferation 
      index and the percentage of CD4(+) and CD8(+) cells. These data indicated that 
      pcAmIL-18 is a potential adjuvant that promotes specific immunity.
FAU - Yan, Yue
AU  - Yan Y
AD  - College of Life Sciences, Sichuan University, Key Laboratory for Bio-Resources 
      and Eco-Environment of the Ministry of Education, Sichuan Key Laboratory of 
      Molecular Biology and Biotechnology, Chengdu 610064, PR China.
FAU - Niu, Lili
AU  - Niu L
FAU - Deng, Jiabo
AU  - Deng J
FAU - Wang, Qiang
AU  - Wang Q
FAU - Yu, Jianqiu
AU  - Yu J
FAU - Zhang, Yizheng
AU  - Zhang Y
FAU - Wang, Jianxi
AU  - Wang J
FAU - Chen, Jiao
AU  - Chen J
FAU - Wei, Changhe
AU  - Wei C
FAU - Tan, Xuemei
AU  - Tan X
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141114
PL  - Japan
TA  - J Vet Med Sci
JT  - The Journal of veterinary medical science
JID - 9105360
RN  - 0 (Adjuvants, Immunologic)
RN  - 0 (Interleukin-18)
RN  - 0 (Viral Vaccines)
SB  - IM
MH  - Adjuvants, Immunologic
MH  - Animals
MH  - Distemper/*prevention & control
MH  - Dogs
MH  - HeLa Cells
MH  - Humans
MH  - Interleukin-18/*pharmacology
MH  - Mice
MH  - Ursidae
MH  - Viral Vaccines/*immunology
PMC - PMC4363021
EDAT- 2014/11/18 06:00
MHDA- 2015/12/15 06:00
PMCR- 2015/02/01
CRDT- 2014/11/18 06:00
PHST- 2014/11/18 06:00 [entrez]
PHST- 2014/11/18 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
PHST- 2015/02/01 00:00 [pmc-release]
AID - DN/JST.JSTAGE/jvms/14-0226 [pii]
AID - 14-0226 [pii]
AID - 10.1292/jvms.14-0226 [doi]
PST - ppublish
SO  - J Vet Med Sci. 2015 Feb;77(2):187-92. doi: 10.1292/jvms.14-0226. Epub 2014 Nov 
      14.