PMID- 25400659
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220330
IS  - 1682-8631 (Print)
IS  - 1682-4016 (Electronic)
IS  - 1682-1769 (Linking)
VI  - 46
IP  - 5
DP  - 2014
TI  - The effects of sleeve gastrectomy on hormonal regulation of glucose metabolism in 
      Goto-Kakizaki rats.
PG  - 189-196
AB  - BACKGROUND: The antidiabetic effect of sleeve gastrectomy (SG) has been 
      interpreted as a conceivable result of surgically induced weight loss in the 
      obese type 2 diabetes mellitus (T2DM) subjects. However, the blood glucose 
      control often occurs within days, before significant weight loss has been 
      reached. This work aims to investigate the major mechanism and persistence 
      regarding how SG improves glucose metabolism in nonobese T2DM rats. METHODS: 
      These Goto Kakizaki rats (n = 21) were randomly assigned into three groups: SG, 
      sham SG, and pair-fed (PF) group, whose weight, food intake, oral glucose 
      tolerance test, insulin tolerance test, plasma insulin, homeostasis model 
      assessment for insulin resistance (HOMA-IR), ghrelin, and glucagon-like peptide-1 
      (GLP-1) were measured. RESULTS: According to the experiment, from the 2nd week 
      until the 24th week, the fasting blood glucose of the rats in the SG group had 
      significantly decreased with the improved glucose tolerance. At the 2nd week 
      postoperation, the area under the blood glucose concentration curve (AUC) 
      received a distinct reduction of 28.1 % (P < 0.0001). The ghrelin secretion of 
      the SG group was significantly decreased (P < 0.005). The GLP-1 had increased 
      (P < 0.0001), while the HOMA-IR values decreased (P < 0.05) throughout the 
      experimental period. These effects were not seen in the sham-SG and PF groups 
      despite similar changes of weight loss or food intake. CONCLUSIONS: The above 
      results suggest that SG can conduct a direct control on T2DM instead of 
      secondarily to weight loss or food intake around the whole experimental period. 
      The changes of the gastrointestinal hormones may be the major mechanism of the 
      antidiabetic effect.
FAU - Zhu, Z
AU  - Zhu Z
AD  - Department of Plastic Surgery, Renmin Hospital of Wuhan University, 238#, Jiefang 
      Road, 430060 Wuhan, Hubei People's Republic of China.
FAU - Yang, X
AU  - Yang X
AD  - Department of Otorhinolaryngology, Renmin Hospital of Wuhan University, 238#, 
      Jiefang Road, 430060 Wuhan, Hubei People's Republic of China.
FAU - Wang, K
AU  - Wang K
AD  - Department of Plastic Surgery, Renmin Hospital of Wuhan University, 238#, Jiefang 
      Road, 430060 Wuhan, Hubei People's Republic of China.
FAU - Wang, Z
AU  - Wang Z
AD  - Department of Plastic Surgery, Renmin Hospital of Wuhan University, 238#, Jiefang 
      Road, 430060 Wuhan, Hubei People's Republic of China.
FAU - Zhao, Y
AU  - Zhao Y
AD  - Department of Plastic Surgery, Renmin Hospital of Wuhan University, 238#, Jiefang 
      Road, 430060 Wuhan, Hubei People's Republic of China.
FAU - Yu, M
AU  - Yu M
AD  - Department of Plastic Surgery, Renmin Hospital of Wuhan University, 238#, Jiefang 
      Road, 430060 Wuhan, Hubei People's Republic of China.
LA  - eng
PT  - Journal Article
DEP - 20140710
PL  - Austria
TA  - Eur Surg
JT  - European surgery : ACA : Acta chirurgica Austriaca
JID - 101140655
PMC - PMC4223536
OTO - NOTNLM
OT  - Gastrointestinal hormones
OT  - Glucose metabolism
OT  - Insulin resistance
OT  - Sleeve gastrectomy
OT  - Type 2 diabetes mellitus
EDAT- 2014/11/18 06:00
MHDA- 2014/11/18 06:01
PMCR- 2014/07/10
CRDT- 2014/11/18 06:00
PHST- 2014/03/10 00:00 [received]
PHST- 2014/06/16 00:00 [accepted]
PHST- 2014/11/18 06:00 [entrez]
PHST- 2014/11/18 06:00 [pubmed]
PHST- 2014/11/18 06:01 [medline]
PHST- 2014/07/10 00:00 [pmc-release]
AID - 270 [pii]
AID - 10.1007/s10353-014-0270-z [doi]
PST - ppublish
SO  - Eur Surg. 2014;46(5):189-196. doi: 10.1007/s10353-014-0270-z. Epub 2014 Jul 10.