PMID- 25400749
OWN - NLM
STAT- MEDLINE
DCOM- 20150709
LR  - 20201209
IS  - 1936-2625 (Electronic)
IS  - 1936-2625 (Linking)
VI  - 7
IP  - 10
DP  - 2014
TI  - Insulin-like growth factor receptor 1 (IGF1R) expression and survival in 
      non-small cell lung cancer patients: a meta-analysis.
PG  - 6694-704
AB  - The insulin-like growth factor receptor-1 (IGF1R) plays an important role in 
      cancer progression. Previous studies have been controversial with respect to the 
      associations between IGF1R expression and non small cell lung cancer (NSCLC) 
      prognosis. Thus, we performed a meta-analysis to investigate the prognostic value 
      of IGF1R expression in NSCLC patients and the relationship between the expression 
      of IGF1R and clinical characteristics. Two independent reviewers searched PubMed, 
      Embase, Ovid Medline and CNKI to identify eligible studies. Overall survival 
      (OS), disease free survival (DFS) and clinicopathological characteristics were 
      collected from included studies. Pooled hazard ratios (HRs) or odds ratios (ORs) 
      with 95% confidence interval (95% CI) were calculated to estimate the effect. 17 
      studies comprising 3,294 patients were included in this meta-analysis. The 
      results showed IGF1R positive expression was associated with an unfavorable DFS 
      in NSCLC patients on univariate analysis (HR = 1.26, 95% CI: 1.09-1.46, P = 
      0.002) and multivariate analysis (HR = 1.49, 95% CI: 1.01-2.20, p = 0.045), but 
      the relationship between IGF1R expression and OS have no significant difference 
      on univariate analysis (HR = 0.91, 95% CI: 0.82-1.01, P = 0.157) and multivariate 
      analysis (HR = 0.79, 95% CI: 0.45-1.41, P = 0.427). Ever smoking and smaller 
      tumor size (T1 or T2) were associated with IGF1R positive expression: pooled OR 
      1.45 (1.13-1.85) and pooled OR 0.61 (0.60-0.95). Our results suggested IGF1R 
      positive expression as an unfavorable factor for DFS in NSCLC patients, and IGF1R 
      expression was associated with smoking status and tumor size.
FAU - Zhao, Shuang
AU  - Zhao S
AD  - Department of Respiratory Medicine, West China Hospital, Sichuan University 
      Chengdu 610041, P. R. China.
FAU - Qiu, Zhixin
AU  - Qiu Z
AD  - Department of Respiratory Medicine, West China Hospital, Sichuan University 
      Chengdu 610041, P. R. China.
FAU - He, Jinlan
AU  - He J
AD  - Department of Radiation Oncology, State Key Laboratory of Biotherapy and Cancer 
      Center, West China Hospital, Sichuan University Chengdu 610041, China.
FAU - Li, Lei
AU  - Li L
AD  - Department of Respiratory Medicine, West China Hospital, Sichuan University 
      Chengdu 610041, P. R. China.
FAU - Li, Weimin
AU  - Li W
AD  - Department of Respiratory Medicine, West China Hospital, Sichuan University 
      Chengdu 610041, P. R. China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20140915
PL  - United States
TA  - Int J Clin Exp Pathol
JT  - International journal of clinical and experimental pathology
JID - 101480565
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (IGF1R protein, human)
RN  - 0 (Receptors, Somatomedin)
RN  - EC 2.7.10.1 (Receptor, IGF Type 1)
SB  - IM
MH  - Biomarkers, Tumor/*analysis
MH  - Carcinoma, Non-Small-Cell Lung/*chemistry/mortality/pathology/therapy
MH  - Chi-Square Distribution
MH  - Disease-Free Survival
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Linear Models
MH  - Lung Neoplasms/*chemistry/mortality/pathology/therapy
MH  - Multivariate Analysis
MH  - Odds Ratio
MH  - Receptor, IGF Type 1
MH  - Receptors, Somatomedin/*analysis
MH  - Risk Factors
MH  - Smoking/*adverse effects
MH  - Time Factors
MH  - Tumor Burden
PMC - PMC4230063
OTO - NOTNLM
OT  - Insulin-like growth factor receptor-1 (IGF1R)
OT  - disease free survival (DFS)
OT  - meta-analysis
OT  - non-small cell lung cancer (NSCLC)
OT  - overall survival (OS)
OT  - prognosis
EDAT- 2014/11/18 06:00
MHDA- 2015/07/15 06:00
PMCR- 2014/09/15
CRDT- 2014/11/18 06:00
PHST- 2014/08/14 00:00 [received]
PHST- 2014/09/13 00:00 [accepted]
PHST- 2014/11/18 06:00 [entrez]
PHST- 2014/11/18 06:00 [pubmed]
PHST- 2015/07/15 06:00 [medline]
PHST- 2014/09/15 00:00 [pmc-release]
PST - epublish
SO  - Int J Clin Exp Pathol. 2014 Sep 15;7(10):6694-704. eCollection 2014.