PMID- 25400753
OWN - NLM
STAT- MEDLINE
DCOM- 20150709
LR  - 20181113
IS  - 1936-2625 (Electronic)
IS  - 1936-2625 (Linking)
VI  - 7
IP  - 10
DP  - 2014
TI  - Expression and prognostic value of MAGE-A9 in laryngeal squamous cell carcinoma.
PG  - 6734-42
AB  - BACKGROUND: Melanoma-associated antigen (MAGE) family genes are reported to play 
      important roles in the development of human cancers. However, the relationship 
      between the expression of MAGE-A9 and clinicopathological characteristics in 
      human laryngeal carcinoma remains unclear. This study aimed to examine the 
      expression of MAGE-A9, and to evaluate the clinical significance of its 
      expression in human laryngeal squamous cell carcinoma (LSCC). METHODS: 
      Quantitative real-time reverse transcription-PCR (qPCR) and immunohistochemistry 
      (IHC) were performed to characterize the expression of MAGE-A9 in LSCC tissues 
      and tumor-adjacent normal tissues. Kaplan-Meier survival and Cox regression 
      analyses were performed to evaluate the prognosis of patients with LSCC. RESULTS: 
      The expression of MAGE-A9 was significantly higher in LSCC than in tumor-adjacent 
      normal tissues. Cytoplasmic expression of MAGE-A9 was detected in 70 of 123 
      (56.9%) LSCC specimens. Levels of MAGE-A9 in LSCC were related to 
      histopathological grade (P = 0.024). Kaplan-Meier survival and Cox regression 
      analysis revealed that MAGE-A9 expression level and lymph node metastasis were 
      independent prognostic factors of LSCC (P = 0.005; P = 0.001, respectively). 
      CONCLUSIONS: Our study suggests that MAGE-A9 expression is a prognostic biomarker 
      for LSCC patients. High expression of MAGE-A9 indicates unfavorable survival 
      outcome in LSCC patients.
FAU - Han, Liang
AU  - Han L
AD  - Department of Radiotherapy & Oncology, Second Affiliated Hospital of Soochow 
      University Suzhou, Jiangsu, China ; Department of Head and Neck Surgery, 
      Affiliated Tumor Hospital of Nantong University, Nantong Tumor Hospital Nantong, 
      Jiangsu, China.
FAU - Jiang, Bin
AU  - Jiang B
AD  - Department of Head and Neck Surgery, Affiliated Tumor Hospital of Nantong 
      University, Nantong Tumor Hospital Nantong, Jiangsu, China.
FAU - Wu, Hao
AU  - Wu H
AD  - Department of Otorhinolaryngology, Affiliated Hospital of Nantong University 
      Nantong, Jiangsu, China.
FAU - Zhang, Shu
AU  - Zhang S
AD  - Department of Clinical Pathology, Affiliated Hospital of Nantong University 
      Nantong, Jiangsu, China.
FAU - Lu, Xueguan
AU  - Lu X
AD  - Department of Radiotherapy & Oncology, Second Affiliated Hospital of Soochow 
      University Suzhou, Jiangsu, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140915
PL  - United States
TA  - Int J Clin Exp Pathol
JT  - International journal of clinical and experimental pathology
JID - 101480565
RN  - 0 (Antigens, Neoplasm)
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (MAGEA9 protein, human)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Antigens, Neoplasm/*analysis/genetics
MH  - Biomarkers, Tumor/*analysis/genetics
MH  - Carcinoma, Squamous Cell/genetics/*immunology/secondary
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Kaplan-Meier Estimate
MH  - Laryngeal Neoplasms/genetics/*immunology/pathology
MH  - Lymphatic Metastasis
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Grading
MH  - Neoplasm Proteins/*analysis/genetics
MH  - Proportional Hazards Models
MH  - RNA, Messenger/analysis
MH  - Real-Time Polymerase Chain Reaction
MH  - Retrospective Studies
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Risk Factors
MH  - Time Factors
MH  - Up-Regulation
PMC - PMC4230163
OTO - NOTNLM
OT  - Laryngeal squamous cell carcinoma
OT  - MAGE-A9
OT  - prognosis
EDAT- 2014/11/18 06:00
MHDA- 2015/07/15 06:00
PMCR- 2014/09/15
CRDT- 2014/11/18 06:00
PHST- 2014/08/27 00:00 [received]
PHST- 2014/09/18 00:00 [accepted]
PHST- 2014/11/18 06:00 [entrez]
PHST- 2014/11/18 06:00 [pubmed]
PHST- 2015/07/15 06:00 [medline]
PHST- 2014/09/15 00:00 [pmc-release]
PST - epublish
SO  - Int J Clin Exp Pathol. 2014 Sep 15;7(10):6734-42. eCollection 2014.