PMID- 25401224
OWN - NLM
STAT- MEDLINE
DCOM- 20150708
LR  - 20151119
IS  - 1600-0447 (Electronic)
IS  - 0001-690X (Linking)
VI  - 131
IP  - 5
DP  - 2015 May
TI  - Brain-derived neurotrophic factor and inflammatory markers in school-aged 
      children with early trauma.
PG  - 360-8
LID - 10.1111/acps.12358 [doi]
AB  - OBJECTIVE: The impact of childhood trauma (CT) on brain-derived neurotrophic 
      factor (BDNF) and cytokines levels remains unclear. We investigated the 
      association between CT and changes in BDNF and cytokines plasma levels in 
      children. METHOD: We recruited 36 children with trauma (CT+) and 26 children 
      without trauma (CT-). The presence of CT was based on a clinical interview and by 
      Criteria A of DSM-IV criteria for PTSD. Blood samples were drawn from all 
      children to assess BDNF and cytokines. ancova was performed with psychiatric 
      symptoms and BMI as covariates to evaluate group differences in plasma levels. 
      RESULTS: CT+ showed increased levels of BDNF and TNF-alpha after excluding children 
      with history of inflammatory disease (P<0.05) when compared with those CT-. 
      IL-12p70, IL-6, IL-8, IL-10, and IL-1beta levels were not statistically different 
      between groups. CONCLUSION: CT+ showed increased BDNF and proinflammatory 
      cytokines levels. The increase in BDNF levels may be an attempt to neutralize the 
      negative effects of CT, while an increase in TNF-a levels be associated with a 
      proinflammatory state after CT. How these changes associated with trauma relate 
      to other biological changes and illness trajectory later in life remain to be 
      further studied.
CI  - (c) 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Bucker, J
AU  - Bucker J
AD  - Bipolar Disorder Program and Laboratory of Molecular Psychiatry, National 
      Institute for Translational Medicine, INCT-TM Hospital de Clinicas de Porto 
      Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
FAU - Fries, G R
AU  - Fries GR
FAU - Kapczinski, F
AU  - Kapczinski F
FAU - Post, R M
AU  - Post RM
FAU - Yatham, L N
AU  - Yatham LN
FAU - Vianna, P
AU  - Vianna P
FAU - Bogo Chies, J A
AU  - Bogo Chies JA
FAU - Gama, C S
AU  - Gama CS
FAU - Magalhaes, P V
AU  - Magalhaes PV
FAU - Aguiar, B W
AU  - Aguiar BW
FAU - Pfaffenseller, B
AU  - Pfaffenseller B
FAU - Kauer-Sant'Anna, M
AU  - Kauer-Sant'Anna M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141117
PL  - United States
TA  - Acta Psychiatr Scand
JT  - Acta psychiatrica Scandinavica
JID - 0370364
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Cytokines)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Biomarkers/blood
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Child
MH  - Child Abuse/*psychology
MH  - Cytokines/*blood
MH  - Diagnostic and Statistical Manual of Mental Disorders
MH  - Female
MH  - Humans
MH  - Inflammation/blood
MH  - Male
MH  - Psychopathology
MH  - *Stress Disorders, Post-Traumatic/blood/diagnosis/etiology/physiopathology
MH  - Tumor Necrosis Factor-alpha/*blood
OTO - NOTNLM
OT  - BDNF
OT  - children
OT  - cytokines
OT  - trauma
EDAT- 2014/11/18 06:00
MHDA- 2015/07/15 06:00
CRDT- 2014/11/18 06:00
PHST- 2014/10/06 00:00 [accepted]
PHST- 2014/11/18 06:00 [entrez]
PHST- 2014/11/18 06:00 [pubmed]
PHST- 2015/07/15 06:00 [medline]
AID - 10.1111/acps.12358 [doi]
PST - ppublish
SO  - Acta Psychiatr Scand. 2015 May;131(5):360-8. doi: 10.1111/acps.12358. Epub 2014 
      Nov 17.