PMID- 25402640
OWN - NLM
STAT- MEDLINE
DCOM- 20150713
LR  - 20211203
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 15
IP  - 11
DP  - 2014 Nov 13
TI  - Current models of mammalian target of rapamycin complex 1 (mTORC1) activation by 
      growth factors and amino acids.
PG  - 20753-69
LID - 10.3390/ijms151120753 [doi]
AB  - Mammalian target of rapamycin (mTOR), which is now referred to as mechanistic 
      target of rapamycin, integrates many signals, including those from growth 
      factors, energy status, stress, and amino acids, to regulate cell growth and 
      proliferation, protein synthesis, protein degradation, and other physiological 
      and biochemical processes. The mTOR-Rheb-TSC-TBC complex co-localizes to the 
      lysosome and the phosphorylation of TSC-TBC effects the dissociation of the 
      complex from the lysosome and activates Rheb. GTP-bound Rheb potentiates the 
      catalytic activity of mTORC1. Under conditions with growth factors and amino 
      acids, v-ATPase, Ragulator, Rag GTPase, Rheb, hVps34, PLD1, and PA have important 
      but disparate effects on mTORC1 activation. In this review, we introduce five 
      models of mTORC1 activation by growth factors and amino acids to provide a 
      comprehensive theoretical foundation for future research.
FAU - Zheng, Xu
AU  - Zheng X
AD  - College of Life Sciences, Inner Mongolia University, Hohhot 010021, China. 
      dong2186@163.com.
FAU - Liang, Yan
AU  - Liang Y
AD  - College of Life Sciences, Inner Mongolia University, Hohhot 010021, China. 
      xixils@163.com.
FAU - He, Qiburi
AU  - He Q
AD  - College of Life Sciences, Inner Mongolia University, Hohhot 010021, China. 
      qbr2010@126.com.
FAU - Yao, Ruiyuan
AU  - Yao R
AD  - College of Life Sciences, Inner Mongolia University, Hohhot 010021, China. 
      18647808043@163.com.
FAU - Bao, Wenlei
AU  - Bao W
AD  - College of Life Sciences, Inner Mongolia University, Hohhot 010021, China. 
      bwlnhm@sina.com.
FAU - Bao, Lili
AU  - Bao L
AD  - College of Life Sciences, Inner Mongolia University, Hohhot 010021, China. 
      baolili1203@126.com.
FAU - Wang, Yanfeng
AU  - Wang Y
AD  - College of Life Sciences, Inner Mongolia University, Hohhot 010021, China. 
      wangyf@life.imu.edu.cn.
FAU - Wang, Zhigang
AU  - Wang Z
AD  - College of Life Sciences, Inner Mongolia University, Hohhot 010021, China. 
      lswzg@imu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20141113
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Amino Acids)
RN  - 0 (Intercellular Signaling Peptides and Proteins)
RN  - 0 (Multiprotein Complexes)
RN  - EC 2.7.11.1 (Mechanistic Target of Rapamycin Complex 1)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Amino Acids/*metabolism
MH  - Animals
MH  - Enzyme Activation
MH  - Humans
MH  - Intercellular Signaling Peptides and Proteins/*metabolism
MH  - Mechanistic Target of Rapamycin Complex 1
MH  - Models, Biological
MH  - Multiprotein Complexes/*metabolism
MH  - *Signal Transduction
MH  - TOR Serine-Threonine Kinases/*metabolism
PMC - PMC4264194
EDAT- 2014/11/18 06:00
MHDA- 2015/07/15 06:00
PMCR- 2014/11/01
CRDT- 2014/11/18 06:00
PHST- 2014/09/04 00:00 [received]
PHST- 2014/09/24 00:00 [revised]
PHST- 2014/10/29 00:00 [accepted]
PHST- 2014/11/18 06:00 [entrez]
PHST- 2014/11/18 06:00 [pubmed]
PHST- 2015/07/15 06:00 [medline]
PHST- 2014/11/01 00:00 [pmc-release]
AID - ijms151120753 [pii]
AID - ijms-15-20753 [pii]
AID - 10.3390/ijms151120753 [doi]
PST - epublish
SO  - Int J Mol Sci. 2014 Nov 13;15(11):20753-69. doi: 10.3390/ijms151120753.