PMID- 25403368
OWN - NLM
STAT- MEDLINE
DCOM- 20150720
LR  - 20181113
IS  - 1471-2474 (Electronic)
IS  - 1471-2474 (Linking)
VI  - 15
DP  - 2014 Nov 18
TI  - Lack of association of matrix metalloproteinase-3 gene polymorphism with 
      susceptibility to rheumatoid arthritis: a meta-analysis.
PG  - 376
LID - 10.1186/1471-2474-15-376 [doi]
LID - 376
AB  - BACKGROUND: Epidemiological studies have investigated the association between 
      matrix metalloproteinase-3(MMP-3) gene-1171 5A/6A polymorphism and rheumatoid 
      arthritis (RA), but the results were inconsistent. To evaluate the specific 
      relationship, we performed a meta-analysis to clarify the controversies. METHODS: 
      The relevant literatures dated to December 07th 2013 were retrieved from PubMed, 
      EMBASE and the China National knowledge Infrastructure (CNKI) databases. The 
      number of the alleles and genotypes for MMP-3 were obtained. Odds ratios (ORs) 
      and 95% confidence intervals (CIs) were used to estimate the association between 
      MMP-3 5A/6A promoter polymorphism and RA. All of the statistical analyses were 
      conducted by STATA11.0 software. RESULTS: A total of 6 case-control studies 
      covering 1451 cases and 1239 controls were included in the final meta-analysis. 
      There was no significant association between MMP-3 5A/6A promoter polymorphism 
      and RA in all genetic models (for 6A versus 5A: OR=1.19, 95% CI=0.91-1.56, 
      P=0.203; 5A/6A versus 5A/5A: OR=1.31, 95% CI=0.89-1.92, P=0.174; 6A/6A versus 
      5A/5A: OR=1.78, 95% CI=0.68-4.61, P=0.238; the recessive model: OR=1.48, 95% 
      CI=0.88-2.47, P=0.141; and the dominant model: OR=1.46, 95% CI=0.71-3.00, 
      P=0.299). In the subgroup analysis by ethnicity, we obtained the similar results. 
      CONCLUSIONS: We systematically investigate the association between MMP-3-1171 
      5A/6A polymorphism and RA susceptibility; however, the results show a lack of 
      correlation. Considering the small sample size and the selection bias existed in 
      some studies, further studies are needed to confirm the findings.
FAU - Feng, Zhitao
AU  - Feng Z
FAU - He, Guochao
AU  - He G
FAU - Chen, Zhuanghong
AU  - Chen Z
FAU - Wu, Zhengzhi
AU  - Wu Z
AD  - Department of Rheumatology, Nanfang Hospital, Southern Medical University, 1838 
      North of Guangzhou Road, Guangzhou, China. szwzz001@163.com.
FAU - Li, Juan
AU  - Li J
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
DEP - 20141118
PL  - England
TA  - BMC Musculoskelet Disord
JT  - BMC musculoskeletal disorders
JID - 100968565
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Arthritis, Rheumatoid/diagnosis/*epidemiology/*genetics
MH  - Case-Control Studies
MH  - *Genetic Association Studies/methods
MH  - Genetic Predisposition to Disease/epidemiology/*genetics
MH  - Humans
MH  - Matrix Metalloproteinase 3/*genetics
MH  - Polymorphism, Genetic/*genetics
PMC - PMC4247749
EDAT- 2014/11/19 06:00
MHDA- 2015/07/21 06:00
PMCR- 2014/11/18
CRDT- 2014/11/19 06:00
PHST- 2014/01/19 00:00 [received]
PHST- 2014/10/15 00:00 [accepted]
PHST- 2014/11/19 06:00 [entrez]
PHST- 2014/11/19 06:00 [pubmed]
PHST- 2015/07/21 06:00 [medline]
PHST- 2014/11/18 00:00 [pmc-release]
AID - 1471-2474-15-376 [pii]
AID - 2322 [pii]
AID - 10.1186/1471-2474-15-376 [doi]
PST - epublish
SO  - BMC Musculoskelet Disord. 2014 Nov 18;15:376. doi: 10.1186/1471-2474-15-376.